DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and Hdac4

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_006529374.1	Gene:	Hdac4 / 208727	MGIID:	3036234	Length:	1100	Species:	Mus musculus

Alignment Length:	1075	Identity:	276/1075 - (25%)
Similarity:	415/1075 - (38%)	Gaps:	306/1075 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILR 163
            :.|.|:..|.:::....|...|..|...|..|. .|.|||.|:                :.|:.:
Mouse   111 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEH-QRKLERHRQ----------------EQELEK 158

  Fly   164 LHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELS---LLASGSTIELVDHLVA---- 221
            .|.|:..::||      :.|:.:|.:.....:.:....|.|:   .||..:    ::|.::
Mouse   159 QHREQKLQQLK------NKEKGKESAVASTEVKMKLQEFVLNKKKALAHRN----LNHCISSDPR 213

  Fly   222 ---GKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQR 283
               ||.|:.......|....:.|.|      |:..|....|.|...|::..
Mouse   214 YWYGKTQHSSLDQSSPPQSGVSASY------NHPVLGMYDAKDDFPLRKTA-------------- 258

  Fly   284 FFYNDPRVVYFS--IHRFEHGSFWPHLHESD-------------------YHAIGSGAGT----- 322
               ::|.:...|  ..:.......|.|...|                   ..|.|||..:
Mouse   259 ---SEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSS 320

  Fly   323 -------GYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDA------ALGCPE 374
                   |....||......:....|...:..:.|:.|...|.|..::.|..|      |.|..:
Mouse   321 GNVSTENGIAPTVPSAPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQD 385

  Fly   375 GEMEVTPACYPHLL-----------------------NPLLR----LADARVAVVLEGGYCLDSL 412
            .|....||....:|                       ||||:    |........|...:.|..|
Mouse   386 AERLALPALQQRILFPGTHLTPYLSTSPLERDGAAAHNPLLQHMVLLEQPPTQTPLVTDWYLSGL 450

  Fly   413 AEGAALTL--RSLLG-DPCPPLV------------ETVPLPRAELAQALLSCIAVHRPHWRCL-- 460
               .||.|  :||:| |...|.:            ::.|||  :.||| |..:.:.:.|.:.|
Mouse   451 ---GALPLHSQSLVGADRVSPSIHKLRQHRPLGRTQSAPLP--QNAQA-LQHLVIQQQHQQFLEK 509

  Fly   461 -----QLQQTY------------DCVELQDRDKEEDL--HTVLRHWIGGPPPMDRYP-------- 498
                 |.||.:            ...|....:.||:|  |..|.    ..|.:||.|
Mouse   510 HKQQFQQQQLHLSKIISKPSEPPRQPESHPEETEEELREHQALL----DEPYLDRLPGQKEPSLA 570

  Fly   499 ------------------TRDT-----------------AIPLPPEKL--------TSNAARLQV 520
                              ||:|                 |:.|..:::        :..||.:.|
Mouse   571 GVQVKQEPIESEEEEAEATRETEPGQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPV 635

  Fly   521 --------LRAETK-------LSV------PSFKVCYAYDAQMLLH-CNLNDT-GHPEQPSRIQH 562
                    .||::.       :||      |.|.....||..||.| |...:| .|||...|||.
Mouse   636 SFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQS 700

  Fly   563 IHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREP--------KEL------- 612
            |.....:.||..:.:.:..|.||.:|:...|:.||.    .|.|..|        |:|
Mouse   701 IWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT----LLYGTNPLNRQKLDSKKLLGSLTSV 761

  Fly   613 ----------HDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQ 667
                      .|:..|:|.|:    :...|.||.|.|::.|..|..||.::|...|||||||||:
Mouse   762 FVRLPCGGVGVDSDTIWNEVH----SSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEE 822

  Fly   668 DHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFF 732
            ..|.|||.||:||:||:...:...:.::||||||||||||||..|.::|.|||:|||||:.|:||
Mouse   823 STPMGFCYFNSVAVAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFF 887

  Fly   733 PKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFD 794
            |  ..|..|.||.|.|.|||||:.:.   :..|||.||..||:.::||||.||.|.:||||:|||
Mouse   888 P--GSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFD 950

  Fly   795 AAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPV-P 856
            |..|  .||||..::|:.:|.||..|..||.||:::.||||:::.:|..|...|...|||:.: |
Mouse   951 AVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELEP 1015

  Fly   857 TPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTASLR 921
            .|:   ..|.:.|..   :.|.|:::.:.:...:||.|:.:...:....:..:...::
Mouse  1016 LPE---KVLHQRPNA---NAVHSMEKVMDIHSKYWRCLQRLSSTVGHSLIEAQKCEKE------- 1067

  Fly   922 HLNISNDDATAAAGGLAGDRP--DCGDERPSGSKP 954
                ..:..||.|....|.:|  ...:|.|...:|
Mouse  1068 ----EAETVTAMASLSVGVKPAEKRSEEEPMEEEP 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	80/428 (19%)
		HDAC6-dom2	538..895	CDD:212527	154/389 (40%)
		zf-UBP	1007..1069	CDD:280334
Hdac4	XP_006529374.1	ClassIIa_HDAC4_Gln-rich-N	<104..165	CDD:197398	16/70 (23%)
Hdac4	XP_006529374.1	HDAC4	665..1073	CDD:212530	157/434 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740