DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and usp-3

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_493434.3	Gene:	usp-3 / 190579	WormBaseID:	WBGene00013506	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	137	Identity:	30/137 - (21%)
Similarity:	55/137 - (40%)	Gaps:	24/137 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   943 DCGDERPSGSKPKVKVKTLSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRPEEAPRSLDSGAEC 1007
            ||.:..|.|             :...|:.:|.:.:|..   ......::::.:|..::.     |
Worm    10 DCVERVPKG-------------MFRKKQDMEDNNLFLE---GNSNRGKVVKNQEIIKTF-----C 53

  Fly  1008 SVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVD---HPRL 1069
            ..|.:..::.:||:|..:.|||..:.|...|..|..||:.:......::||:|...|.   .|.|
Worm    54 DECDNCNKSLMCLTCGRILCGRNDSGHALHHFEETSHPVVIDCISFELYCYSCDDEVSLDFEPSL 118

  Fly  1070 YAYLNPL 1076
            |..|..|
Worm   119 YGVLKSL 125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527
		zf-UBP	1007..1069	CDD:280334	18/64 (28%)
usp-3	NP_493434.3	zf-UBP	53..111	CDD:366940	16/57 (28%)
usp-3	NP_493434.3	UCH	229..542	CDD:366104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810