DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and hda-11

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_505699.3	Gene:	hda-11 / 183226	WormBaseID:	WBGene00007953	Length:	334	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	76/316 - (24%)
Similarity:	138/316 - (43%)	Gaps:	58/316 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RFTRVLERCRELNL-TERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEEL------ 188
            ::.||:...:|:|| |:..|..|: ..|.:|:.|:|..::.:      .:|:..:..::
Worm    42 KWRRVITHLKEMNLITDETLVEPN-LPTFEELTRVHDRKYLK------SVRNPIKAAQIVEIPFV 99

  Fly   189 ----SSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKA-QNGMAIIRPPG-HHAMKAEYNGYC 247
                ....:|..:||    |.|.|.|:.      |.|..| ::|.||....| |||..:...|:|
Worm   100 GCLPPCIIESKLLHP----LRLQAGGTV------LAANLALKHGWAINVGGGFHHASHSGGGGFC 154

  Fly   248 FFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESD 312
            |:.::.:|.....|...:...:::|.|.|.|.|..|.|.::|.|..|.:       |.|:::..|
Worm   155 FYADITMAIFDLFDKKAIANAIVVDLDAHQGNGHARDFADNPNVFVFDV-------FNPYVYPHD 212

  Fly   313 YHAIGSGAGTGYNFNVPLNATG-MTNGDYLAIFQQLLLPVALEFQP------ELIIVSAGYDAAL 370
            ..|       ....|..::..| .|:..||:..::.|....::.:.      :.|:.:||.|..|
Worm   213 REA-------RQFINRAVHVNGHTTDTSYLSELRKQLAQCLIDREKTTPPGFDFIMFNAGTDCLL 270

  Fly   371 GCPEGEMEVTPACYPHLLNPLLRLADAR---VAVVLEGGYCLDSLAEGAALTLRSL 423
            |.|.|.|:::|.|.......:..||.::   :.:|..|||..|:    |.|..:|:
Worm   271 GDPLGAMKLSPQCIIARDEVVFNLAKSKGIPICMVTSGGYQKDN----ALLIAKSI 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	76/316 (24%)
		HDAC6-dom2	538..895	CDD:212527
		zf-UBP	1007..1069	CDD:280334
hda-11	NP_505699.3	HDAC_classIV	36..325	CDD:212519	76/316 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810