DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hda-4

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001257278.1	Gene:	hda-4 / 181723	WormBaseID:	WBGene00001837	Length:	869	Species:	Caenorhabditis elegans

Alignment Length:	996	Identity:	251/996 - (25%)
Similarity:	389/996 - (39%)	Gaps:	286/996 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SKSKTGTTGAA------------TAAGGTGSSSGSIS-----------------GGFNAADPRKS 58
            :.|.||:.|.|            .|.|.|.....||:                 |.|..|....|
Worm     4 ASSSTGSAGGAGPSVPNLPSTSEAAIGQTNLEPESIALLQSQLQEYRQKQMDLIGHFQRAQQELS 68

  Fly    59 ----NKPNAAL--------LEAKRRARNNMLKNQGCGSQE-------------SVTDIFQNAVNS 98
                :...|||        |:.:|.|.|.:|.:|...:::             |:|::..::..:
Worm    69 VQHMHNLYAALQQQQQLQNLQTERSAVNPLLISQQHSTEDQNSGPAAPLSLANSLTNLLSSSNGN 133

  Fly    99 KSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELP-SRSATKDEIL 162
            .|:.:.||                |||:.......|            :| :|| |.|.|..::.
Worm   134 LSVPQTPT----------------KEHHPTAPTSNR------------KC-DLPRSNSTTISQLT 169

  Fly   163 RLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNG 227
            :       :|||.....|........|:...:          |:.|:|:     .|....|.:|.
Worm   170 K-------DRLKNMIANRSKGESNSQSNLMSN----------SVTANGN-----GHDNGRKLKNS 212

  Fly   228 MAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQ--------------------RILII- 271
            .:.:.....|           |....|.|..| :.|.||                    |..::
Worm   213 NSQVNVSSPH-----------FEPYRLPTSLA-NAHNLQQASEFQLRKVNSEPNLKMRIRAKLLS 265

  Fly   272 --DYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATG 334
              ...|.|.|.....|            .|.|    |.|..||...         :.||||
Worm   266 KGSSPVQHVQQNNSQF------------NFTH----PQLKRSDSET---------SQNVPL---- 301

  Fly   335 MTNGDYLAIFQQLLLPVALEFQPEL-IIVSAGYDAALGCPEGE--------MEVTP-ACYPHLLN 389
                |::....|..||..:...|.| .:.:||....|..|.|:        ..::| ...|.|||
Worm   302 ----DFMQSSSQTNLPHLMLPSPSLPNLAAAGAFHGLNLPVGQDLNAFMAVANLSPFLSLPSLLN 362

  Fly   390 PLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHR 454
            ..|.|          ||...:....|       |:|              :....:|.|.:::..
Worm   363 KKLEL----------GGLTDEGDRNG-------LIG--------------SSSTSSLASNVSMGS 396

  Fly   455 PHWRCLQLQQTYDCV----ELQDRDKE----EDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKL 511
            ..::.|..||..|.|    .|...|.|    .:|:..|                     ||..||
Worm   397 HQYQSLLKQQIRDLVLRRKSLVREDPEGEGLAELYNGL---------------------LPQAKL 440

  Fly   512 TSNAARLQVLRAETKLSVPSFKVC---YAYDAQMLLH--CNLNDTGHPEQPSRIQHIHKMHDDYG 571
                .:||.|.||:.........|   ..||..|:.|  |..|:..|.|...|||.|.....::|
Worm   441 ----QQLQALAAESGFLAKQEPTCTTGLGYDQAMVRHECCCGNNASHVENGGRIQSIWSKLIEHG 501

  Fly   572 LLKQMKQLSPRAATTDEVCLAHTRAHVN-----------------TVRRLLGREPKELH-DAAGI 618
            .:::.::::.:.|:.:::.|.|::.:..                 .::|.|     :|. ...|:
Worm   502 HVQKCEKVTAKKASLEQLQLVHSQTYTTFFAVSPTACLKIDANSLPLKRFL-----QLPCGGIGV 561

  Fly   619 YNSVYLH-PRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIA 682
            .:..|.: ..|...|.||||.:::....|..|..::|...:||||||||.:...|||.|||||:|
Worm   562 DSDTYFNDASTQTAARLAAGTLIELSSQVAEGRLKNGFACIRPPGHHAEHEQAMGFCFFNNVAVA 626

  Fly   683 AQYAIRDFGLE--RVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGK 745
            .:.....:..:  ::.|:|||||||||||..||::|.|||:||||::.|:|||  ..|:...|||
Worm   627 VKVLQTKYPAQCAKIAIIDWDVHHGNGTQLSFENDPNVLYMSLHRHDKGNFFP--GTGSVTEVGK 689

  Fly   746 GAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDP--LGGCKVTA 808
            ...:|..||:|::...|.|.||..|::.:|.|:...|.|..::|||||||..|.|  |||.:||.
Worm   690 NDAKGLTVNVPFSGDVMRDPEYLAAWRTVIEPVMASFCPDFIIVSAGFDACHGHPNALGGYEVTP 754

  Fly   809 EGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAF 873
            |.:|.:|..|...|||::::.|||||::.|||.|...|.:.|:|:.....:|.:.||:..|.
Worm   755 EMFGYMTKSLLNYASGKVVLALEGGYDLKSISEAAQQCVQALIGESDDAGRLSSVALESLPN--- 816

  Fly   874 QSCVESLQQCLQVQRNHWRSL 894
            .|.||:||:.:.:.:::|.:|
Worm   817 PSAVETLQKVIAIHKSYWPAL 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	69/371 (19%)
		HDAC6-dom2	538..895	CDD:212527	134/382 (35%)
		zf-UBP	1007..1069	CDD:280334
hda-4	NP_001257278.1	HDAC_classIIa	460..834	CDD:212544	133/383 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850