Protein Alignment HDAC6 and hda-6

DIOPT Version :9

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001122780.1
• Gene: hda-6 / 177316
• WormBaseID: WBGene00018319
• Length: 957
• Species: Caenorhabditis elegans
• Alignment Length: 1035
• Identity: 381/1035 - (36%)
• Similarity: 565/1035 - (54%)
• Gaps: 121/1035 - (11%)

  Fly    91 IFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECP------ERFTRVLERCRELNLTERCL 149
            :|::...::|  ..||.:.::::.::|      |:..||      :|..::.|...:..:.|:|.
 Worm     2 LFEDRQKNRS--TGPTLIGFNQTQNEH------ENTVCPTHPESSDRILKIKEALTKTKILEKCT 58

  Fly   150 ELPSRSATKDEILRL-HTEEHFERLKETSGIRDDERMEELSS---RYDSIYIHPSTFELSLLASG 210
            .|.:.....|..|.: |.:...:.|.|:    :.:..|:::|   :|||:::  :.|:.|:..:.
 Worm    59 VLTNFLEIDDADLEVTHDKSMVKDLMES----EKKTQEDINSQCEKYDSVFM--TEFQNSMKVAK 117

  Fly   211 STI----ELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILII 271
            ..:    :|.:.::|.:|.||.|::|||||||......|:|.|||||.|.:.|. ....:||||:
 Worm   118 DGVACVRDLTNRIMANEASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAF-FSGAERILIV 181

  Fly   272 DYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMT 336
            |.|||||.||||.||:|.||:||||||.|||.|||||.|||:..||||.|.|||.|:.||.||.|
 Worm   182 DLDVHHGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCT 246

  Fly   337 NGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAV 401
            :.|||:|...:|||:|.:|.|..:|:|||:||.||.|.|.|.:||..|.|:|..|..||..|:.|
 Worm   247 DSDYLSIIFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLV 311

  Fly   402 VLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTY 466
            ||||||.....|......:|.||| ..|..:|....|:.....:.:|.::|.|.||.|.....:
 Worm   312 VLEGGYNHQISAVAVQRCVRVLLG-YAPFSIELNEAPKESTVDSCVSLVSVLRHHWNCFDYFPS- 374

  Fly   467 DCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPS 531
                          .|.||        :.::|..:|.:....:..|..|...::::.|  |:...
 Worm   375 --------------RTSLR--------LAQWPIVNTKVIYNYDPTTRRADTGEIIQDE--LASTE 415

  Fly   532 F---KVCYAYDAQMLL--------HCNLNDTGHPEQPSRIQHIHKMHDDYGLL-KQMKQLSPRAA 584
            |   .|....:.:.|:        |.:|.:..|||:|:|.:.|.|...:.|:| |.:.:...|.|
 Worm   416 FTASDVIPTENMETLIYFNEGDDAHFDLEEDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIA 480

  Fly   585 TTDEVCLAHTR---AHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSV 646
            |.:|:.|.||:   .|:.|...:  ::.:.:.:|...:||:||...|...|..|.|.|||:||.:
 Worm   481 TNEEIRLVHTKKMLEHLRTTETM--KDEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEI 543

  Fly   647 LRGES--RSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQ 709
            ...::  |:.:..||||||||......|||||||||:||:||.|....:||||:|||||||||||
 Worm   544 FEKDAGQRNALVIVRPPGHHASASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQ 608

  Fly   710 HIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQL 774
            .||..:..|:|:|:||::.|:|:|.|...::..||:|||.|.:||:|::...|||.||.:|||::
 Worm   609 EIFYEDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRV 673

  Fly   775 IMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSI 839
            ||||||:|||.|||:|||||||:.||||..|||.|.:.::|:.||:||.||||..||||||:.||
 Worm   674 IMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSI 738

  Fly   840 S-YAMTMC----TKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGR 899
            | .|..:|    .:::|.......:..||..||..:    ||::::::...||:.:|..|:  |.
 Worm   739 SNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIES----SCIKTIREVCAVQQKYWSILK--GF 797

  Fly   900 RLPRDPVVGENNNEDFLTASLRHLNIS----NDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKT 960
            :               :|.|...|:|.    :||:...|     |:........|.::|
 Worm   798 Q---------------VTPSNYGLDIDDEAYDDDSIDMA-----DQSSSSGSSSSSTRP------ 836

  Fly   961 LSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRPEEAPRSLDSGAECSVCGSTGENWVCLSCRHV 1025
                 :.|.|.::.....||.||.|||||:.::| ..|..:::...||.|....|.|.||:|...
 Worm   837 -----SHNLEIMDSGPAHAVVPLATCPHLKEVKP-LPPAKINARTACSECQIGAEVWTCLTCYKY 895

  Fly  1026 ACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRLYAYLNPLHEDKFQEPM 1085
            .|||:||.|...|.:...||:|:|.||||||||.|.:||.:|.|....:..||.||.|.|
 Worm   896 NCGRFVNEHAMMHHLSSSHPMALSMADLSVWCYPCDSYVHNPALIGAKSAAHESKFGETM 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	140/351 (40%)
		HDAC6-dom2	538..895	CDD:212527	159/375 (42%)
		zf-UBP	1007..1069	CDD:280334	31/61 (51%)
hda-6	NP_001122780.1	Arginase_HDAC	32..366	CDD:388375	138/341 (40%)
		Arginase_HDAC	440..795	CDD:388375	158/360 (44%)
		zf-UBP	877..939	CDD:366940	31/61 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165904
Domainoid	1	1.000	279	1.000	Domainoid score	I902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31353
Inparanoid	1	1.050	621	1.000	Inparanoid score	I481
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45835
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	1	1.000	-	-		oto18448
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X2174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940