Protein Alignment HDAC6 and hda-3

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_493026.1
• Gene: hda-3 / 173074
• WormBaseID: WBGene00001836
• Length: 465
• Species: Caenorhabditis elegans
• Alignment Length: 338
• Identity: 88/338 - (26%)
• Similarity: 159/338 - (47%)
• Gaps: 32/338 - (9%)

  Fly   533 KVCYAYDAQMLLHCNL-NDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRA 596
            :|.|.||...   .|. ...|||.:|.|::..|.:..:|||.:::..:.|..|:..|:...|:..
 Worm     9 RVSYYYDGDF---GNFYYGQGHPMKPHRVRMTHSLIVNYGLYRKLNVMRPARASFSEITRYHSDD 70

  Fly   597 HVNTVRRLLGREPKELHDAAG---------IYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESR 652
            ::|.:|.:.........|...         :::.:|      :...|:.|..|.|...:.|.||.
 Worm    71 YINFLRNVKSDNMSTFTDQMARFSVGEDCPVFDGMY------EFCQLSCGGSLAAAARLNRQESE 129

  Fly   653 SGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPK 717
            ..| |.....|||::....|||..|::.:|....::..  :|||.:|.|||||:|.:..|.:..:
 Worm   130 IAI-NWMGGLHHAKKSEASGFCYSNDIVLAILELLKHH--KRVLYIDIDVHHGDGVEEAFYTTDR 191

  Fly   718 VLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEF 782
            |:.:|.|:  ||.:||  ..|:...||.|:|:.:.:|:|. :.|:.|:.|...|:.::..:...|
 Worm   192 VMTVSFHK--HGEYFP--GTGDLKDVGAGSGKYYALNVPL-RDGVDDVTYERIFRTIMGEVMARF 251

  Fly   783 NPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSIS----YAM 843
            .|:.|::..|.|:..||.||...:|..|:|....::.:.....::|. .|||.:.::|    |..
 Worm   252 QPEAVVLQCGADSLAGDRLGVFNLTTYGHGKCVEYMKSFNVPLLLVG-GGGYTIRNVSRCWLYET 315

  Fly   844 TMCTKTLLGDPVP 856
            .:.....:.|.:|
 Worm   316 AIALNQEVSDDLP 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	86/333 (26%)
		zf-UBP	1007..1069	CDD:460464
hda-3	NP_493026.1	HDAC_classI	13..318	CDD:212517	84/322 (26%)