Protein Alignment HDAC6 and Hdac10

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001403078.1
• Gene: Hdac10 / 170787
• MGIID: 2158340
• Length: 667
• Species: Mus musculus
• Alignment Length: 793
• Identity: 253/793 - (31%)
• Similarity: 377/793 - (47%)
• Gaps: 145/793 - (18%)

  Fly   106 TALIYDESMSQHCCLWDKE--HYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEE 168
            |||:|.|.|:....|||..  ..|||||.|..|:..|:..|.||||.|.:..|:::|:..:|:.|
Mouse     3 TALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPE 67

  Fly   169 HFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRP 233
            :...:::|..: |.|.:..||.:|:::|.||.||..:.||:|:.::|||.::.|...||:|::||
Mouse    68 YIALVQKTQTL-DKEELHALSKQYNAVYFHPDTFHCARLAAGAALQLVDAVLTGAVHNGLALVRP 131

  Fly   234 PGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHR 298
            ||||:.:|..||:|.|||||||.:||...:.||||||:|:|||||||.|..|.:||.|:|||.||
Mouse   132 PGHHSQRAAANGFCVFNNVALAAKHAKQKYGLQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHR 196

  Fly   299 FEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVS 363
            :|||||||.|.|||..|:|.|.|.|:..|:|.|..||.|.||||.|..:|||:|.||.|||::||
Mouse   197 YEHGSFWPFLPESDADAVGQGQGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVS 261

  Fly   364 AGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPC 428
            ||:|:|:|.|||:|:.||.|:.||...|..||..|:..||||||.|:|||:...:.:::|||||.
Mouse   262 AGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPT 326

  Fly   429 PPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPP 493
            |||:..: :|.....:::.|......|:|..||                :::..||......|
Mouse   327 PPLLGLM-VPCQSALESIQSVQTAQTPYWTSLQ----------------QNVAPVLSSSTHSP-- 372

  Fly   494 MDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPS 558
                  .:.::.|..|..|...       ||..||....::|.                .|..|
Mouse   373 ------EERSLRLLGESPTCAV-------AEDSLSPLLDQLCL----------------RPAPP- 407

  Fly   559 RIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNS-- 621
                         :...:....|.||    :||                .|..||....:...
Mouse   408 -------------ICTAVASTVPGAA----LCL----------------PPGVLHQEGSVLREET 439

  Fly   622 ---VYLHPRTF---DCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVA 680
               ..||...|   |.|||  |.:|..:|.::.|:.|:.|.........|..|          |.
Mouse   440 EAWARLHKSRFQDEDLATL--GKILCLLDGIMDGQIRNAIATTTALATAATLD----------VL 492

  Fly   681 IAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGK 745
            |....|.|   .:|||.|  .:...:....:.:...::|::::          :|.|.....:
Mouse   493 IQRCLARR---AQRVLCV--ALGQLDRPLDLADDGRRILWLNI----------RGKDAAIQSM-- 540

  Fly   746 GAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEG 810
                 |:.:.|..:...|.|...|.   |::|:||.|.|.:||::.|       |..|.: .|:.
Mouse   541 -----FHFSTPLPQTTGGFLSLILG---LVLPLAYGFQPDMVLMALG-------PAHGLQ-NAQA 589

  Fly   811 YGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPT--PQLGATALQKPPTVAF 873
             .:|...|.:...|||:..:|    ..||........:.|.|:..|:  |...||..:....:..
Mouse   590 -ALLAAMLRSPVGGRILAVVE----EESIRLLARSLAQALHGETPPSLGPFSKATPEEIQALMFL 649

  Fly   874 QSCVESLQQCLQV 886
            ::.:|:..:.|||
Mouse   650 KARLEARWKLLQV 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	162/339 (48%)
		HDAC6-dom2	538..895	CDD:212527	71/359 (20%)
		zf-UBP	1007..1069	CDD:460464
Hdac10	NP_001403078.1	Histone deacetylase	1..323		158/320 (49%)
		Arginase_HDAC	18..354	CDD:450134	161/337 (48%)