| Sequence 1: | NP_001259569.1 | Gene: | HDAC6 / 32461 | FlyBaseID: | FBgn0026428 | Length: | 1179 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001123888.1 | Gene: | Hdac6 / 15185 | MGIID: | 1333752 | Length: | 1149 | Species: | Mus musculus |
| Alignment Length: | 1183 | Identity: | 453/1183 - (38%) |
|---|---|---|---|
| Similarity: | 625/1183 - (52%) | Gaps: | 193/1183 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 41 SSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNA----VNSKSL 101
Fly 102 VRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHT 166
Fly 167 EEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAII 231
Fly 232 RPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI 296
Fly 297 HRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELII 361
Fly 362 VSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGD 426
Fly 427 PCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRH----- 486
Fly 487 -WIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLND 550
Fly 551 TGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDA 615
Fly 616 AGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVA 680
Fly 681 IAAQYA--IRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVV 743
Fly 744 GKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTA 808
Fly 809 EGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAF 873
Fly 874 QSCVESLQQCLQVQRNHWRSL--------------EFVGRRLP---------------------- 902
Fly 903 ----------RDPVVGENNNE-----------------------------------DFLTASLRH 922
Fly 923 LNISNDDATAAAGGLAGDRPDCG--DERPSGSKP----------KVKVKTLSDYLAENKEALEQS 975
Fly 976 E-----------------------------MFAVYPLKTCPHLRLLRPEEAPRSLDSGAECSVCG 1011
Fly 1012 STGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRLYAYLNPL 1076
Fly 1077 HEDKFQEPMAWTH 1089 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HDAC6 | NP_001259569.1 | HDAC10_HDAC6-dom1 | 119..457 | CDD:212526 | 156/337 (46%) |
| HDAC6-dom2 | 538..895 | CDD:212527 | 186/372 (50%) | ||
| zf-UBP | 1007..1069 | CDD:280334 | 35/61 (57%) | ||
| Hdac6 | NP_001123888.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..61 | 14/44 (32%) | |
| Histone deacetylase 1 | 87..403 | 149/316 (47%) | |||
| Arginase_HDAC | 98..434 | CDD:418394 | 156/337 (46%) | ||
| Histone deacetylase 2 | 481..799 | 169/327 (52%) | |||
| HDAC6-dom2 | 484..834 | CDD:212527 | 185/358 (52%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 954..975 | 4/20 (20%) | |||
| zf-UBP | 1067..1129 | CDD:396634 | 35/61 (57%) | ||
| Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 | 1088..1090 | 0/1 (0%) | |||
| Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 | 1116..1123 | 4/6 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167848479 | |
| Domainoid | 1 | 1.000 | 318 | 1.000 | Domainoid score | I1257 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0123 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H31353 | |
| Inparanoid | 1 | 1.050 | 811 | 1.000 | Inparanoid score | I481 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG45835 | |
| OrthoDB | 1 | 1.010 | - | - | D1484694at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001161 | |
| OrthoInspector | 1 | 1.000 | - | - | oto93243 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100220 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR48252 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2991 |
| SonicParanoid | 1 | 1.000 | - | - | X2174 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 17 | 16.800 | |||||