DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and Hdac5

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_017169770.1	Gene:	Hdac5 / 15184	MGIID:	1333784	Length:	1133	Species:	Mus musculus

Alignment Length:	1105	Identity:	280/1105 - (25%)
Similarity:	431/1105 - (39%)	Gaps:	312/1105 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 RKSNKPNAALLEAKR-------RARNN----------------MLKNQGCGSQESV--TDI---F 92
            :|..|....:|.|||       |.|..                :|:|:....:.::  |::   .
Mouse   133 QKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRL 197

  Fly    93 QNAVNSKSLVRKPTALIYDESMSQHCCLWDKEH-------------------YECPERFTRVLER 138
            |..:.|||  ::||....:.|:.||...|...|                   |:.|
Mouse   198 QEFLLSKS--KEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLP--------- 251

  Fly   139 CRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFE 203
              .|...:...:.|.|....:..|::.:     |||:...   :.|...|..|.|...|  |||:
Mouse   252 --LLGPYDSRDDFPLRKTASEPNLKVRS-----RLKQKVA---ERRSSPLLRRKDGTVI--STFK 304

  Fly   204 ---LSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKL 265
               :.:..:|..:..|.:...|...:.     |...|:..|| ||  |..:|.......:..|
Mouse   305 KRAVEITGTGPGVSSVCNSAPGSGPSS-----PNSSHSTIAE-NG--FTGSVPNIPTEMIPQH-- 359

  Fly   266 QRILIIDYDVHHGQGTQRFFYNDPRVVYFSIH-------RFEHGSFWPHL---HESDYHAIGSGA 320
             |.|.:|     ....|...|..|.:...|:.       ...|.:..|.|   .|::..|:.|
Mouse   360 -RALPLD-----SSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQS-- 416

  Fly   321 GTGYNFNVPLNATGMTNGDYLAI--FQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPAC 383
                     |...|...|.:::.  ....||.|||                      |.:.:|..
Mouse   417 ---------LRQGGTLTGKFMSTSSIPGCLLGVAL----------------------EGDTSPHG 450

  Fly   384 YPHLLNPLLRLADAR-----VAVVLEGGYCLDSLAEGAALTLRSLLGDPCP---PLVETVPLPRA 440
            :..||..:|.|..||     :||.|.|...|.: .|..|.::|::  ...|   ||..|...|..
Mouse   451 HASLLQHVLLLEQARQQSTLIAVPLHGQSPLVT-GERVATSMRTV--GKLPRHRPLSRTQSSPLP 512

  Fly   441 ELAQALLSCIAVHRPHWRCLQLQ------------------------------------------ 463
            :..|||.. :.:.:.|.:.|:.|
Mouse   513 QSPQALQQ-LVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGE 576

  Fly   464 -----------------------------QTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPT 499
                                         :..||::::|.|.|           .||   |..|.
Mouse   577 GALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGE-----------SGP---DEGPD 627

  Fly   500 RDTAIPLPPEKLTSNAARLQVL------------------RAETKLSVPS--------------- 531
            .:.: ....:||.::|.:||.|                  |.::..:.|.
Mouse   628 LEES-SAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDQPTVVKHL 691

  Fly   532 FKVCYAYDAQMLLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHT 594
            |.....||..||.| |...:|. |||...|||.|.....:.|||.:.:::..|.||.||:...|:
Mouse   692 FTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHS 756

  Fly   595 RAHVNTV------------RRLLGREPKELH----------DAAGIYNSVYLHPRTFDCATLAAG 637
            ..|....            ::|||...::::          |:..::|.::    :.....:|.|
Mouse   757 EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMH----SSSAVRMAVG 817

  Fly   638 LVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDV 702
            .:::....|..||.::|...:||||||||:....|||.||:|||.|:...:...:.:|||||||:
Mouse   818 CLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDI 882

  Fly   703 HHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGD 764
            |||||||..|.::|.|||||||||::|:|||  ..|..:.||.|.|.|:|||:.|.   ...:||
Mouse   883 HHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 945

  Fly   765 LEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRII 827
            :||..||:.::||||.||:|.:|||||||||..|  .||||..|||..:|.||..|..||.||::
Mouse   946 VEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVV 1010

  Fly   828 VCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWR 892
            :.||||:::.:|..|...|...||.  |....|....||:.|:|   :.|.:|::.:::|..||.
Mouse  1011 LALEGGHDLTAICDASEACVSALLS--VELQPLDEAVLQQKPSV---NAVATLEKVIEIQSKHWS 1070

  Fly   893 SLEFVGRRLP---RDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKP 954
            .::.....|.   |:...||....:.::| :..|::..:.|.|.|......||   .|.|...:|
Mouse  1071 CVQRFAAGLGCSLREAQTGEKEEAETVSA-MALLSVGAEQAQAVATQEHSPRP---AEEPMEQEP 1131

Fly 955 954
Mouse 1132 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	76/379 (20%)
		HDAC6-dom2	538..895	CDD:212527	149/385 (39%)
		zf-UBP	1007..1069	CDD:280334
Hdac5	XP_017169770.1	ClassIIa_HDAC_Gln-rich-N	87..174	CDD:391182	8/40 (20%)
Hdac5	XP_017169770.1	HDAC5	690..1109	CDD:212531	156/430 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750