Protein Alignment HDAC6 and Hdac6

DIOPT Version :9

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_003752058.1
• Gene: Hdac6 / 108348065
• RGDID: 619981
• Length: 1152
• Species: Rattus norvegicus
• Alignment Length: 1186
• Identity: 461/1186 - (38%)
• Similarity: 629/1186 - (53%)
• Gaps: 204/1186 - (17%)

  Fly    41 SSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNA----VNSKSL 101
            ||:....||...|.|..|  ||  |.|.|::.:...|      ||.:..|:....    :||::.
  Rat    26 SSATLKRGGKKGAVPHSS--PN--LAEVKKKGKMKKL------SQPAEEDLIVGLQGLDLNSETR 80

  Fly   102 VRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHT 166
            |...|.|::||.::...||||....|.|||...:.|:.....|..||:...:|.|.|:|::.:|:
  Rat    81 VPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHS 145

  Fly   167 EEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAII 231
            .|:.: |.||:...::..:..|:..|||:|:||:::..:.||:||.:.|||.::..:.:||||:|
  Rat   146 LEYID-LMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVI 209

  Fly   232 RPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI 296
            |||||||.::..:|||.||::|:|.::|...|::|||||:|:|||||||||..|..||.|:||||
  Rat   210 RPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSI 274

  Fly   297 HRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELII 361
            ||:|||.|||||..|::...|.|.|.||..|||.|..||.:.||:|.|..:|||||.||||:|::
  Rat   275 HRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHILLPVAFEFQPQLVL 339

  Fly   362 VSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGD 426
            |:||:||..|.|:|||..|||.:.||.:.|:.||..::.:.|||||.|.:||:|.:.:|.:||||
  Rat   340 VAAGFDALHGDPKGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGD 404

  Fly   427 PCPPLVETVPLPRAELAQALLSC-IAVHRPHWRCLQLQQTYDCVELQD---------RDKEEDLH 481
            || |::|:...|.|. ||..:|| :....|.|..|:..     ||.||         .|:||:
  Rat   405 PC-PMLESPVAPCAS-AQTSISCTLEALEPFWEVLERS-----VEPQDEDEVEGDMLEDEEEE-- 460

  Fly   482 TVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHC 546
               .||.....|||.:|                     :|:..|.|         .||.:|:.||
  Rat   461 ---GHWEATALPMDTWP---------------------LLQNRTGL---------VYDERMMSHC 492

  Fly   547 NLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKE 611
            ||.|..|||.|.||..|....::.||..:...|..|.|...|:...|:..:|..:|.....:.::
  Rat   493 NLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRD 557

  Fly   612 LHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIF 676
            ||.....:.|:|:.|.||.||.||.|...:.|::||.||..:||..|||||||||.|...|||.|
  Rat   558 LHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFF 622

  Fly   677 NNVAIAAQYA--IRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGN 739
            |:||:||::|  |....| |:||||||||||||||||||.:|.|||:|||||:.|:|||.|.:|.
  Rat   623 NSVAVAARHAQVIAGRAL-RILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGA 686

  Fly   740 FDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGC 804
            ...||:.||.||.||:|||...|||.:|...:.:|::||||||||:|||:|||||||.|||||||
  Rat   687 SSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGC 751

  Fly   805 KVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPP 869
            :||.|||..|||.|..||.||||:.||||||:.|||.:|..||.:||||  |.|||  |:|:.|.
  Rat   752 QVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGD--PPPQL--TSLRPPQ 812

  Fly   870 TVAFQSCVESLQQCLQVQRNHWRSLEFV------------------------------------- 897
            :.|    :.|:.:.:||.|.:||||..:
  Rat   813 SGA----LASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKV 873

  Fly   898 ---GRRLP------RDPVVGE-------------NNNEDFLTASLRHLNISNDD---------AT 931
               |.|.|      ::..:|:             .::|.....:...|..|.|.         |:
  Rat   874 LEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCAS 938

  Fly   932 AAAGGLAGDRPDCGDE----------RPSGS------------------KPKVKVKTLSDYLAEN 968
            .||...:.::...|:|          .||.:                  .|::.:.:..:..:|.
  Rat   939 VAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEA 1003

  Fly   969 KEALEQSE-----------------------------MFAVYPLKTCPHLRLLRPEEAPRSLDSG 1004
            :|..|..|                             .:||.||..||||..:.|..| ..||..
  Rat  1004 QEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPA-AGLDVS 1067

  Fly  1005 AECSVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRL 1069
            ..|..|||..||||||:|..|.|.|||||||..|....:|||.:|..|||.|||.|.|||.|..|
  Rat  1068 QPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDL 1132

  Fly  1070 YAYLNPLHEDKFQEPM 1085
            ....|..|::||.|.|
  Rat  1133 QDVKNAAHQNKFGEGM 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	158/338 (47%)
		HDAC6-dom2	538..895	CDD:212527	186/358 (52%)
		zf-UBP	1007..1069	CDD:280334	36/61 (59%)
Hdac6	XP_003752058.1	Arginase_HDAC	98..434	CDD:418394	158/338 (47%)
		HDAC6-dom2	484..834	CDD:212527	186/358 (52%)
		zf-UBP	1070..1132	CDD:396634	36/61 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840