DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac10

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_002932227.1	Gene:	hdac10 / 100497245	XenbaseID:	XB-GENE-5857298	Length:	671	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	256/826 - (30%)
Similarity:	396/826 - (47%)	Gaps:	199/826 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 TALIYDESMSQHCCLWDKEH--YECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEE 168
            |||:|||.|..:..|||.:.  .|.|||.:...:|.::.:|.:||.:||.|.||.:||..:|:.:
Frog     5 TALVYDEEMMSYKLLWDDQECSIEVPERLSSSYKRLQDYDLVKRCTQLPVREATDEEITLVHSSD 69

  Fly   169 HFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRP 233
            :.|.:|.|..:.:.| :||:|.:|.:::.|.::|..:.|:.|.|::|||.:::|:.|||||::||
Frog    70 YLEVVKSTQTMNEKE-LEEISRKYTAVFFHQNSFRCAKLSLGGTLQLVDAVLSGEVQNGMALVRP 133

  Fly   234 PGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHR 298
            ||||:.:.:.||:|.|||||:|.::|...:||:||||:|:|||||||.|..|..||.|:|||.||
Frog   134 PGHHSQRDQGNGFCVFNNVAIAAEYAKKKYKLERILIVDWDVHHGQGIQYIFEEDPSVLYFSWHR 198

  Fly   299 FEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVS 363
            :||.:|||:|.||||:|:|.|.|||:|.|:|.|..||:|.||:|:|..:|||:|.||.|||::||
Frog   199 YEHKTFWPYLSESDYNAVGRGKGTGFNINLPWNKVGMSNADYIAVFFHVLLPLAFEFNPELVLVS 263

  Fly   364 AGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPC 428
            ||||:|:|.|||.|..||.|:.||.:.|:.|||.::..||||||.|.||||...:|:|:|||||.
Frog   264 AGYDSAIGDPEGRMCATPECFSHLTSMLMNLADGKLCAVLEGGYNLRSLAESVCMTVRTLLGDPL 328

  Fly   429 PPLV-ETVPLPRAELAQALLSCIAVHRPHWRCL----QLQQTYDCVELQDRDKEEDLHTVLRHWI 488
            |.|. |..|...|  .:::.:..|.|.|:|:||    .|:..:      |...:|:|.:.|
Frog   329 PKLTGEMTPCHSA--LESIQNVRAAHSPYWKCLLCDGNLRSAH------DPGSKENLDSQL---- 381

  Fly   489 GGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGH 553
                ..|:....|||:         ..:.|.....|...:.|..:.|    |.:...|:|
Frog   382 ----SSDQQQNIDTAV---------FDSFLDSHMKEITFAAPPLRTC----AVLPEGCSL----- 424

  Fly   554 PEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAH---TRAHVNTVRRLLGREPKELHDA 615
                                          |..|.|.|..   ||.||.....|.   |.||.:.
Frog   425 ------------------------------ALPDGVLLEEETATREHVIASSSLF---PYELLEK 456

  Fly   616 AGIYNSVYLHPRTFDCATLAAGLVL-------QAVDSVLRGESRSGICNVRPPGHHAEQDHPHGF 673
            ..:            .|||...||:       |.::::..... |.:|
Frog   457 ESM------------LATLGKTLVVLNKLIAYQTMNAIALSPD-SSVC----------------- 491

  Fly   674 CIFNNVAIAAQYAIRDFGLERVLIVD-WDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPD 737
                 .|:|.|:.:.. .::|:..:: .|:    |.:|..:::.|.|.:::     ...:|.|..
Frog   492 -----AAVAIQHVLAS-EVKRLYCINIGDI----GMKHESQNDGKFLCLNI-----CGAYPTGMS 541

  Fly   738 GNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQL---IMPIAYEFNPQLVLVSAGFDAAIGD 799
            .|..:.           :.|.:  ..| ||:..|..|   |:|:||.:.|..::::.|.:..|||
Frog   542 NNRQIY-----------VKWTE--CSD-EYSSFFYILFCCILPLAYNYQPDFIIITTGCNRTIGD 592

  Fly   800 PLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATA 864
                     :...:|...|..||:||||..:                       |...|:||...
Frog   593 ---------KDIALLVSLLQGLANGRIIAVI-----------------------PETEPKLGEML 625

  Fly   865 L---------------QKPPTVAFQSCVESLQQCLQVQRNHWRSLE 895
            :               :.||.    ..::.|.:.|.|.:..|:.|:
Frog   626 VKCMSGSPGEKHFGPHRAPPL----EIIQDLNEKLLVIQKEWKMLQ 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	164/340 (48%)
		HDAC6-dom2	538..895	CDD:212527	68/385 (18%)
		zf-UBP	1007..1069	CDD:280334
hdac10	XP_002932227.1	HDAC10	20..356	CDD:212546	163/338 (48%)
hdac10	XP_002932227.1	Arginase_HDAC	<538..633	CDD:418394	29/140 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	330	1.000	Domainoid score	I1167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	1	1.000	-	-		oto103488
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060