Protein Alignment HDAC6 and hdac6

DIOPT Version :9

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_031746852.1
• Gene: hdac6 / 100379853
• XenbaseID: XB-GENE-5873935
• Length: 1056
• Species: Xenopus tropicalis
• Alignment Length: 1143
• Identity: 400/1143 - (34%)
• Similarity: 562/1143 - (49%)
• Gaps: 192/1143 - (16%)

  Fly    21 MASKSKTGTTGAATAAGGTGSSSGSISGGFNAADPRKSNKP--NAALLEAKRRA---------RN 74
            |||.:...|:|  |..|..||...|     ..|..||...|  :.:|.:.|:|.         |.
 Frog    11 MASSAGAQTSG--TPRGMRGSLPLS-----RKAPRRKGASPQGSQSLRKLKKRGAHRMRRTRPRR 68

  Fly    75 NMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERC 139
            :.:..:|.|.:....   :.||..       |.|:|||.|:|.||.||:...|||.|...|.::.
 Frog    69 SCVTTRGTGGEPYKA---RQAVQG-------TGLVYDEQMAQTCCXWDENFPECPARIWAVRDKM 123

  Fly   140 RELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFEL 204
            .|..|.|||:.:.:|.|:::||..:|:.::...:..|..:..:| ::.||.||||:|:||::|..
 Frog   124 AEYGLAERCVAVQAREASEEEISLIHSPQYVALMGSTQNMNVEE-LQALSDRYDSVYLHPTSFTC 187

  Fly   205 SLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRIL 269
            :.||.||.::|||.::..:.:||:|::|||||||...:.||||.||.:|:|.::|...:..:|:|
 Frog   188 ASLAVGSVLQLVDKVLRREIRNGLAVVRPPGHHAHVDQMNGYCMFNQLAIAARYAQRTYGAKRVL 252

  Fly   270 IIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATG 334
            |:|:|||||||||..|.|||.|:|||:||:|:|.|||||.||...|:|...|..:|.||..|.|.
 Frog   253 IVDWDVHHGQGTQFLFENDPSVLYFSVHRYENGGFWPHLRESASSAVGKERGERFNVNVAWNKTR 317

  Fly   335 MTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARV 399
            |::.||:.:|..:|||:|.||||.|::|:||:|:.:|.|:|||..||.|:.||.:.|:.||..|:
 Frog   318 MSDADYIHVFLNILLPIAYEFQPHLVLVAAGFDSVVGDPKGEMSATPGCFSHLTHLLMSLAQGRL 382

  Fly   400 AVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLS---CIAVHRPHWRCLQ 461
            .:.|||||...|||||....|::|||||||.|    |||.|....||.|   .::.|...|:.
 Frog   383 ILSLEGGYNQRSLAEGVCACLKALLGDPCPKL----PLPSAPCQSALDSISDTLSAHCRLWKV-- 441

  Fly   462 LQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETK 526
                     |||.:.|.:.       |..|...:..|. |.|...|.||:... :.::|:|
 Frog   442 ---------LQDYESEGEA-------IDEPQSAEEQPP-DGADEPPLEKVLEQ-SMMEVMR---- 484

  Fly   527 LSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCL 591
             .||:.:....||.||:.|.|:.|:.|||.|.||..|.|.|.|.|||.:..:: |.|       |
 Frog   485 -EVPAQRTALVYDEQMMEHHNMWDSCHPESPQRINQIFKRHKDLGLLDRCSRI-PSA-------L 540

  Fly   592 AHTR---------AHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVL 647
            .|:.         :::..:.......|:.. .....||.:|::.|::..|.||||.....|::|:
 Frog   541 GHSEGLQMCTGGLSYIQKIEASATXTPRPA-PTGDEYNXIYINSRSYHSARLAAGSTFSVVEAVV 604

  Fly   648 RGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLE-------RVLIVDWDVHHG 705
            .|::::|:|.|||..|..:.....|||.||.||..|:||.|   |.       ||:|:||.||||
 Frog   605 TGKAQNGVCIVRPGSHMQKPAEACGFCFFNTVAQPARYAQR---LRSRXEDPLRVMILDWXVHHG 666

  Fly   706 NGTQHIFESNPK-VLYISLHRYEHGSFFPKGPDGNFD--VVGKGAGRGFNVNIPWNKKGMGDLEY 767
            |||||||:..|. |||:|||||:.|.|||...:.:..  .:|||||..:  |||||....||.|.
 Frog   667 NGTQHIFQRMPGCVLYVSLHRYDEGLFFPNSEEHHMTRFAIGKGAGSMW--NIPWNGSKXGDPEI 729

  Fly   768 ALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEG 832
            .:||.:::||||||.......: ||||...|||||.||.:.||...|||.|..||.||:|:.|||
 Frog   730 LMAFHRVVMPIAYELTRSWFCI-AGFDGPAGDPLGACKXSPEGNAXLTHLLMGLAGGRVILVLEG 793

  Fly   833 GYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEF- 896
            |||.:.||.:.........|||.||    .:.|:.|...||    .|:::..|..|...|||..
 Frog   794 GYNQHPISESHGYVHSLPSGDPPPT----LSDLRPPKPSAF----NSVRKVRQAHRQVGRSLRLN 850

  Fly   897 ----VGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDR---------------- 941
                ....|...||:.......|.|.:.....||:...|:....|..||
 Frog   851 VAPQGAHNLQHSPVMXNPQKGRFATEAGPSAMISHKGLTSQQDPLRRDRHSLHRHSAQTSVAETP 915

  Fly   942 ----------PDCGDERPSGS-----------KPKVKVKTLSDYLAENKEALEQSEMFAVYPLKT 985
                      |..||...:|:           .|.:..:||.:.:|.
 Frog   916 RPLVPESRFLPRGGDPHKAGAAGRGCGGSEAETPTIGFETLMESMAN------------------ 962

  Fly   986 CPHLRLLRPEEAPRSLDSGAECSVCGSTGENWVCLSC----RHVACGRYVNAHMEQHSVEEQ--- 1043
                            :||.:|.........|:|..|    ...|.||||:   ..|:|...
 Frog   963 ----------------ESGEDCITPLPGAPTWLCECCAPGGSGCAVGRYVS---PTHAVPWTCLW 1008

  Fly  1044 HPLAMSTADLSVWCYACSAYVDH---PRLYAYLNPLHE 1078
            |.|....:|||||||.|.:||.|   |.....|..|.|
 Frog  1009 HHLVSQFSDLSVWCYGCESYVHHQVTPHKAGVLGGLRE 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	154/340 (45%)
		HDAC6-dom2	538..895	CDD:212527	149/375 (40%)
		zf-UBP	1007..1069	CDD:280334	25/71 (35%)
hdac6	XP_031746852.1	Arginase_HDAC	103..439	CDD:418394	154/340 (45%)
		Arginase_HDAC	495..848	CDD:418394	149/375 (40%)
		zf-UBP	978..1033	CDD:396634	23/57 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31353
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2174
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110