DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac7

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_002935701.3	Gene:	hdac7 / 100158627	XenbaseID:	XB-GENE-488662	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	217/688 - (31%)
Similarity:	317/688 - (46%)	Gaps:	124/688 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 PVALEFQPELIIVSAGYDAALGCPEGEMEVTPA---CYPHLLNPLLRLAD---------ARVAVV 402
            |:|...||.:|:..:|....|...:|...|..|   ..|....||.|...         .:..::
Frog   317 PLATRLQPVIILEQSGAHTPLVAVQGLGSVQFAHAFISPDHHKPLSRTRSEPLPQNPKTLQQQLL 381

  Fly   403 LEGGYCL--DSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPH--------- 456
            .:..|.:  :.:.:...|:.||......|.|.:   :|..|:.::  |.....||:
Frog   382 YQQQYSIFPEHMKQQRQLSKRSQKTSERPRLSQ---IPSEEMDES--SSPTADRPNDVGGNPARA 441

  Fly   457 ----------------WRCLQLQQTYDCVELQDRDKEEDLHTVLRHWI---------GGPPPMDR 496
                            .:.:|.||.......|....|..||..:...:         ||..|:.|
Frog   442 RSESLRVGQHETLSSSQQAIQQQQQQHSFHQQAYLYESSLHRPVNRPLDVLTIPLMPGGHRPLSR 506

  Fly   497 YPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLH-CNLND-TGHPEQPSR 559
            ..:...:..||.::.::.|..:.:|...||   |.|.....||:.||.| |...| :.|||...|
Frog   507 AKSSPASASLPAQEPSAKAMSIPMLEQATK---PRFTTGIVYDSVMLKHQCTCGDNSNHPEHAGR 568

  Fly   560 IQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHV--------NTV----RRLLGREPKEL 612
            ||.|.....:.||....:.:..|.||.:|:...||..||        |.:    |:|.|...:.:
Frog   569 IQSIWSRLQERGLRNNCECIRGRKATLEELQSVHTETHVLLYGTNPLNRLKLDNRKLAGILSQRM 633

  Fly   613 H----------DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQ 667
            .          |:..|:|.::    :.:.|..|||.|:.....|...|.::|...||||||||:.
Frog   634 FVMLPCGGLGVDSDTIWNELH----SSNAARWAAGSVIDLAFKVASRELKNGFALVRPPGHHADP 694

  Fly   668 DHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFF 732
            ....|||.||:|||||:.......:.::||||||||||||||.:|.::|.||||||||::.|:||
Frog   695 STAMGFCFFNSVAIAAKQLQLRRDVRKILIVDWDVHHGNGTQRVFYTDPNVLYISLHRHDDGNFF 759

  Fly   733 PKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFD 794
            |  ..|..|.||.|.|.|||||:.|.   ...|||:||..||:.::||||:||:|.:||||||||
Frog   760 P--GSGAADEVGAGNGEGFNVNVAWTGGLDPPMGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFD 822

  Fly   795 AAIGD--PLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLG---DP 854
            ||.|.  ||||.||||:.:|.:|..|.:||.||:::.||||:::.||..|...|...|||   ||
Frog   823 AAEGHPAPLGGYKVTAKCFGHMTRQLMSLAGGRVVLALEGGHDLTSICDASEACVSALLGNELDP 887

  Fly   855 VPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTAS 919
            :|.    .|..|:|.    |:.|.||:..:.||..:|.|::....::....:..:.::.|.:
Frog   888 LPE----ETLRQRPN----QNAVCSLETVIHVQSKYWTSVKQFASKVQYTLLEAQKHDRDEV--- 941

  Fly   920 LRHLNISNDDATAAAG--------GLAGDRPDCGDERP 949
                    |..||.|.        .:||:||   .|.|
Frog   942 --------DTVTALASLSVGRGSIAVAGNRP---QEEP 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	25/145 (17%)
		HDAC6-dom2	538..895	CDD:212527	162/388 (42%)
		zf-UBP	1007..1069	CDD:280334
hdac7	XP_002935701.3	HDAC7	539..916	CDD:212532	161/390 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010