DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC6 and HDAC5

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:XP_016879477.1 Gene:HDAC5 / 10014 HGNCID:14068 Length:1161 Species:Homo sapiens


Alignment Length:1071 Identity:286/1071 - (26%)
Similarity:427/1071 - (39%) Gaps:287/1071 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 LEAKRRARNNMLKNQGCGSQESV---TDI---FQNAVNSKSLVRKPTALIYDESMSQHCCLWDKE 124
            ||.:|..:..::......|:||.   |::   .|..:.|||  ::||....:.|:.||...|...
Human   194 LEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPTPGGLNHSLPQHPKCWGAH 256

  Fly   125 H-------------------YECPERFTRVLERCRELNLTERCLELPSRSATKDEI-LRLHTEEH 169
            |                   |:.|                     ||....::|:. ||....| 
Human   257 HASLDQSSPPQSGPPGTPPSYKLP---------------------LPGPYDSRDDFPLRKTASE- 299

  Fly   170 FERLKETSGIRD---DERMEELSSRYDSIYIHPSTFE---LSLLASGSTIELVDHLVAGKAQNGM 228
             ..||..|.::.   :.|...|..|.|...|  |||:   :.:..:|.....|.:...|...:. 
Human   300 -PNLKVRSRLKQKVAERRSSPLLRRKDGTVI--STFKKRAVEITGAGPGASSVCNSAPGSGPSS- 360

  Fly   229 AIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVY 293
                |...|:..|| ||  |..:|.......|..|   |.|.:|     ....|...|..|.:..
Human   361 ----PNSSHSTIAE-NG--FTGSVPNIPTEMLPQH---RALPLD-----SSPNQFSLYTSPSLPN 410

  Fly   294 FSIH-------RFEHGSFWPHL---HESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAI--FQQ 346
            .|:.       ...|.:..|.|   .|::..|:.|           |...|...|.:::.  ...
Human   411 ISLGLQATVTVTNSHLTASPKLSTQQEAERQALQS-----------LRQGGTLTGKFMSTSSIPG 464

  Fly   347 LLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADAR-----VAVVLEGG 406
            .||.||||..              |.|.|        :..||..:|.|..||     :||.|.|.
Human   465 CLLGVALEGD--------------GSPHG--------HASLLQHVLLLEQARQQSTLIAVPLHGQ 507

  Fly   407 YCLDSLAEGAALTLRSL------------LGDPCPP----------------------------- 430
            ..|.: .|..|.::|::            ...|.|.                             
Human   508 SPLVT-GERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLG 571

  Fly   431 --LVETVPLPR-------------AELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDL 480
              |.:|..|||             .|..:.||...|:..|.....:.:.|.:  :|::.|:|:| 
Human   572 KILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQE--DLEEEDEEDD- 633

  Fly   481 HTVLRHWIGGPPPMDRYPTRD----TAIPLPPE---------KLTSNAARLQVL----------- 521
                     |....|....:|    :.....|:         ||.|:|..||.|           
Human   634 ---------GEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLAT 689

  Fly   522 -------RAETKLSVPS-------------FKVCYAYDAQMLLH-CNLNDTG-HPEQPSRIQHIH 564
                   |.::..:.|.             |.....||..||.| |...:|. |||...|||.|.
Human   690 VPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIW 754

  Fly   565 KMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTV------------RRLLGREPKELH---- 613
            ....:.|||.:.:::..|.||.||:...|:..|....            ::|||...::::    
Human   755 SRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP 819

  Fly   614 ------DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHG 672
                  |:..::|.::    :.....:|.|.:|:....|..||.::|...:||||||||:....|
Human   820 CGGIGVDSDTVWNEMH----SSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMG 880

  Fly   673 FCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPD 737
            ||.||:|||.|:...:...:.:|||||||:|||||||..|.::|.|||||||||::|:|||  ..
Human   881 FCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GS 943

  Fly   738 GNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG- 798
            |..:.||.|.|.|:|||:.|.   ...:||:||..||:.::||||:||:|.:|||||||||..| 
Human   944 GAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGH 1008

  Fly   799 -DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGA 862
             .||||..|||..:|.||..|..||.||:::.||||:::.:|..|...|...||.  |....|..
Human  1009 LSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLS--VELQPLDE 1071

  Fly   863 TALQKPPTVAFQSCVESLQQCLQVQRNHWRSLE----FVGRRLPRDPVVGENNNEDFLTASLRHL 923
            ..||:.|.:   :.|.:|::.:::|..||..::    .:||.| |:...||....:.::| :..|
Human  1072 AVLQQKPNI---NAVATLEKVIEIQSKHWSCVQKFAAGLGRSL-REAQAGETEEAETVSA-MALL 1131

  Fly   924 NISNDDATAAAGGLAGDRPDCGDERPSGSKP 954
            ::..:.|.|||......||   .|.|...:|
Human  1132 SVGAEQAQAAAAREHSPRP---AEEPMEQEP 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526 85/436 (19%)
HDAC6-dom2 538..895 CDD:212527 149/385 (39%)
zf-UBP 1007..1069 CDD:280334
HDAC5XP_016879477.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2991
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.750

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