DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dah and dmd

DIOPT Version :9

Sequence 1:	NP_511162.1	Gene:	dah / 32459	FlyBaseID:	FBgn0015926	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001313616.1	Gene:	dmd / 83773	ZFINID:	ZDB-GENE-010426-1	Length:	3609	Species:	Danio rerio

Alignment Length:	681	Identity:	132/681 - (19%)
Similarity:	218/681 - (32%)	Gaps:	211/681 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117
            |..|.:::.||.|.|...:||......:.........::|||... |..:...|:.:.|..:|..
Zfish  3004 DLNNVRFSAYRTAMKLRRMQKALCLDLLSMPAACEAFEQHNLKQN-EQFMDIVQVINCLTSIYDR 3067

  Fly   118 CEKLGHFNQDANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCKLYSSDHLVGDIFG 182
            .|:    ...:...:.....:..|:..||||..|...|..|..:...|.|||.:..|..
Zfish  3068 LEQ----QHSSLVNVPLCVDMCLNWLLNVYDTGRAGKIRTLSFKTGIISLCKAHLEDKY------ 3122

  Fly   183 LLADPKSQIISRYAFEQ---------------LLATLSKLLSYLGEAKAYGVHNLPLAMEQCFAR 232
                       |:.|.:               ||....::...|||..::|..|:..::..||
Zfish  3123 -----------RFLFREVASATGFCDQRRLGLLLHDAIQIPRQLGEVASFGGSNIEPSVRSCF-- 3174

  Fly   233 CPHGVGGLTEPQF--HKLWTGAGVQTRFLIYGNL-------LALVKRIEDTEHLIHSNSCAGCRK 288
                       ||  :|....|.|   ||.:..|       |.::.|:...|...|...|..|::
Zfish  3175 -----------QFANNKPELEASV---FLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKE 3225

  Fly   289 EHIVGIRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPL---RWTRHLARLCGWL 350
            ..|:|.|:|.....:..:|..|    |..||...||:|....||...|.   ...|..|::.
Zfish  3226 CPIIGFRYRSLKHFNYDICQSC----FFSGRVAKGHKMQYPMVEYCTPTTSGEDVRDFAKVL--- 3283

  Fly   351 VMPRKTQEEERRGFCNAQESG--PAL----GQSAATPI-----------PA-------------- 384
                |.:...:|.|......|  |..    |.:..||:           ||
Zfish  3284 ----KNKFRTKRYFAKHPRMGYLPVQTILEGDNMETPVTLINFWPVDHPPASSPQLSHDDTHSRI 3344

  Fly   385 ----------ETRS--------------------VRSQCQEKDRTVVLQQQQQELCSLTGLASEA 419
                      |.|:                    ::..||..::...|.|.|.....|..:.:|.
Zfish  3345 EHYASRLAEMENRNGSYVNDNVSPNESMDDEHLLIQHYCQSLNQGSPLSQPQSPAQILISMETEE 3409

  Fly   420 SSRLQSIIDRLLLQNAKLETQLQTVATASSSEISQFLSAHQCFLLQIIEDMRQLSHASAVTSPPP 484
            ...|:.:::.|..:|.||:           :|..:...||         |.:.|   |.:.|||.
Zfish  3410 KGELERVLNDLEQENRKLQ-----------AEYDRLKKAH---------DHKGL---SPLPSPPQ 3451

  Fly   485 -APAAQVAPSAAPLVSSTFLSSSTPQR-----QMLFDMYAPVGANLTHSINGADLNRSYLEANKS 543
             .|.:..:|..|.|::...|......|     |:|.|....:.:.||..       |..||..::
Zfish  3452 MLPVSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLTRL-------RQLLEQPQT 3509

  Fly   544 DYSLNDISLWFDQRRSSVQPGQGPGSLPAPLPLPMPLGALLEQQPANGGDGRDTEMVNFKLLLHK 608
            :..:|..:|                                 ..|:......||.:.:.::...:
Zfish  3510 ESKVNGTAL---------------------------------SSPSTASPRSDTSLASLRVAASQ 3541

  Fly   609 VKEIVEDSYSDNAELSAATQNLENVLDSIIK 639
            ..|.:.|.     |||:.||:....|:.:|:
Zfish  3542 TTETMGDD-----ELSSPTQDASTGLEDVIE 3567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EF-hand_2	44..168	CDD:286194	25/114 (22%)
dah	NP_511162.1	ZZ_dah	281..329	CDD:239085	14/47 (30%)
dmd	NP_001313616.1	CH	33..136	CDD:237981
		CH	152..257	CDD:237981
		SPEC	359..577	CDD:238103
		SPEC	580..844	CDD:238103
		SPEC	741..950	CDD:238103
		SPEC	856..1063	CDD:238103
		SPEC	1067..1281	CDD:238103
		SPEC	1180..1388	CDD:238103
		SPEC	1486..1586	CDD:197544
		SPEC	1591..1788	CDD:238103
		SPEC	1823..1973	CDD:295325
		SPEC	2074..2279	CDD:238103
		SPEC	2381..2595	CDD:238103
		SPEC	2599..2841	CDD:238103
		SPEC	2843..>2962	CDD:295325
		WW	<2973..2995	CDD:238122
		EF-hand_2	2997..3114	CDD:286194	25/114 (22%)
		EF-hand_3	3118..3209	CDD:286195	22/123 (18%)
		ZZ_dystrophin	3218..3266	CDD:239074	15/51 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910