DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dah and drp2

DIOPT Version :9

Sequence 1:	NP_511162.1	Gene:	dah / 32459	FlyBaseID:	FBgn0015926	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_009289397.1	Gene:	drp2 / 558055	ZFINID:	ZDB-GENE-070228-4	Length:	1001	Species:	Danio rerio

Alignment Length:	676	Identity:	125/676 - (18%)
Similarity:	219/676 - (32%)	Gaps:	213/676 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117
            |..|.|::.||.|.|...:||...........|:.:.....|..|..:|    .:..::|.:...
Zfish   451 DLNNIKFSAYRTAMKLRHVQKALRLDLFKLSSVVDVFREQELQHGEHVM----DVVEVIHALTSL 511

  Fly   118 CEKLGHFNQDANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCKLYSSDHLVGDIFG 182
            .|:|.. .:.....:.....:..|:..||||..|...:.:|..::..::||.
Zfish   512 YERLEE-ERSVLINIPLCVDMCLNWLLNVYDSGRNGKMRVLSFKMGLVILCN------------- 562

  Fly   183 LLADPKSQIISRYAFEQLLAT--------LSKLL-------SYLGEAKAYGVHNLPLAMEQCFAR 232
              ||.:.:.  :|.|.|:...        ||.||       ..|||..|:|..|:..::..||..
Zfish   563 --ADIQEKY--KYLFRQVCGPGGLTDQKHLSLLLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRM 623

  Fly   233 CPHGVGGLTEPQFHKLWTGAGVQTRFLIYGNLLALVKRIEDTEHLIHSNSCAGCRKEHIVGIRFR 297
                |.|.:..:.........::.:.:::   |.::.|:...|...|...|..|::..|.|.|:|
Zfish   624 ----VSGKSAIELSHFLEWMSLEPQSVVW---LPVLHRVTVAETAKHQARCYICKQCPIKGFRYR 681

  Fly   298 CQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPLRWTRHLARLCGWLVMPRKTQEEERR 362
            .....::.:|..||..    ||...|.::....:|...|                  .|..|:.|
Zfish   682 SLKQFNVDICQTCFLT----GRTTKGKKLHYPIMEYYTP------------------TTSGEKMR 724

  Fly   363 GFCNAQES----------GPALGQSAATPIPAETRSVRSQCQEKDRTVVLQQQQQEL-CSLTGLA 416
            .|....::          .|..|.     :|.::              ||:.:..|. ||...|.
Zfish   725 DFAKTLKNKFRSKQYFSKHPQRGY-----LPVQS--------------VLEVESSETPCSSPRLP 770

  Fly   417 -SEASSRLQSIIDRLLLQNAKLETQ-----LQTVATASSSEISQFL-----------SAHQCFLL 464
             ::..||::....||    |::|.|     ..:::...|.:..|:|           |.|...|.
Zfish   771 HADTHSRIEHFASRL----AEMENQNCSFFTDSLSPDESLDEDQYLLRHSSPSLEQDSPHGLMLA 831

  Fly   465 QI-IEDMRQL-----------------------SHASAVTSP------PPAPAAQ-----VAPSA 494
            |: .:|..:|                       .|..|..||      |.:|..|     :|.:.
Zfish   832 QLDCQDREELQRTLHRLENENRVLQGEYRRLKWKHEEAAASPQLLESGPGSPPGQQDEELLAEAR 896

  Fly   495 APLVSSTFLSSSTPQRQMLFDMYAPVGANLTHSINGADLNRSYLEANKSDYSLNDISLWFDQRRS 559
            ......|.|.:   :.|:|.|....:.:.|...       |..|...|.|...|
Zfish   897 VLRQHKTRLET---RMQILEDHNKQLESQLRRL-------RELLLQPKDDSEAN----------- 940

  Fly   560 SVQPGQGPGSLPAPLPLPMPLGALLEQQPANGGDGRDTEMVNFKLLLHKVKEIVEDSYSDNAELS 624
                |..|.||.:|:              :.|..|                   |....:..:..
Zfish   941 ----GSAPSSLSSPV--------------SGGHQG-------------------EPPSRETTDTE 968

  Fly   625 AATQNLENVLDSIIKSE---EQQRRI 647
            ||.::|::..|::::.:   ||.|.:
Zfish   969 AAGEDLDHEQDTVLQLQQVIEQLRNV 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EF-hand_2	44..168	CDD:286194	23/114 (20%)
dah	NP_511162.1	ZZ_dah	281..329	CDD:239085	12/47 (26%)
drp2	XP_009289397.1	SPEC	163..396	CDD:238103
		WW	414..442	CDD:238122
		EF-hand_2	443..561	CDD:286194	23/114 (20%)
		EF-hand_3	565..656	CDD:286195	19/99 (19%)
		ZZ_dystrophin	665..713	CDD:239074	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12268
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010