DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dah and DYTN

DIOPT Version :9

Sequence 1:	NP_511162.1	Gene:	dah / 32459	FlyBaseID:	FBgn0015926	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001087199.1	Gene:	DYTN / 391475	HGNCID:	23279	Length:	578	Species:	Homo sapiens

Alignment Length:	668	Identity:	129/668 - (19%)
Similarity:	239/668 - (35%)	Gaps:	175/668 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MD-DLQRDYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDR--------HNLSGGLELMV 102
            || |.|....:.:.::||.|.|..::|.:.....|...|:..:|.|        |:||
Human     1 MDPDKQDALNSIENSIYRTAFKLQSVQTLCQLDLIDSSLIQQVLLRPSFWEARKHSLS------- 58

  Fly   103 PPFQLTSLLHDVYFACEKLGHFNQDANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILL 167
             ..||:..|.:::   :|....|....:  .||..|..:....:|:.:....:.|:......|.|
Human    59 -VQQLSQALQELF---QKAREENPGQVH--PRAPELTLSLLTTMYNSKGTGFLQLMPAAAALITL 117

  Fly   168 CKLYSSDHLVGD---IFGLLAD---------PKSQIISRYAFEQLLATLSKLLSYLGEAKAYGVH 220
                |.|..:..   :|.|.|:         |:   ::|....:||..|.::.:::||::|.
Human   118 ----SGDSPLSKYRALFQLYAENSRGGYDSGPR---MTRRVLRKLLTDLQQIPTFVGESRAL--- 172

  Fly   221 NLPLAMEQCFARCPHGVGGLTEPQFHKLWTGAGVQTRFLIYGN-------LLALVKRIEDTEHLI 278
                        ||  |...|...|..:.:.|..:.:||.:..       .|....|:...|.:.
Human   173 ------------CP--VESATRSCFQGVLSPAIKEEKFLSWVQSEPPILLWLPTCHRLSAAERVT 223

  Fly   279 HSNSCAGCRKEHIVGIRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPLRWTRHL 343
            |...|..||...|.|:|:||..|.:..:|..||..|.....|:..|.:.|..::          :
Human   224 HPARCTLCRTFPITGLRYRCLKCLNFDICQMCFLSGLHSKSHQKSHPVIEHCIQ----------M 278

  Fly   344 ARLCGWLVMPRKTQEEERRGFCNAQESG---PALGQSAATPIP--AETRSVRSQC-QEKDR-TVV 401
            :.:....::.|..:....:|.|..:|:.   ..|.|.....:|  |:.|.::.|. |.||: ..:
Human   279 SAMQNTKLLFRTLRNNLLQGRCRKKEAARRQQLLDQVNPKGVPHHAQARLLKKQLNQYKDKLQAI 343

  Fly   402 LQQQQQELCSLTGLASEASSRLQSIIDRLLLQNAKLETQLQTVATASSSEISQFLSAHQCFLLQI 466
            ...|::.:|           |.::.|.:|......|.|:||                      ||
Human   344 YTSQEERIC-----------RFETRIHKLKTNQDSLWTKLQ----------------------QI 375

  Fly   467 IEDMRQLSHASAVTSPPPAPAAQVAPSAAPLVSSTFLSSSTPQRQMLFDMYAPVGANLTHSINGA 531
            ..|::       ....||.|::    |:...|.:....|||.:        .|.|.:.....|..
Human   376 RRDLQ-------ARLQPPGPSS----SSFQNVGNKVDHSSTEK--------VPKGGDYLQIKNAT 421

  Fly   532 -------------DLNRSYLEANKSDYSLN-----DISLWFDQRRSSVQ--PGQGPGSLPA---- 572
                         :::||:.....::::|.     :.:|...:.:|..|  |.:...:||:
Human   422 EDASTGEPLPKLDEVDRSHRSHTNAEHALRNPESPETTLHSTRAQSQTQKMPQKVISALPSYQEG 486

  Fly   573 ---------PLPLPMPLGALLEQQPANGGDGRDTEMVNFKL--LLHKVKEIVE------DSYSDN 620
                     |..:..|..|.:|::.|.....|..|:...:|  ||.|:.:...      ...|.|
Human   487 LKQDIPKMVPAEMSSPALAAVEKKEAGNIKERKDELEEEELQELLSKLMDAFNLETPSGPESSVN 551

  Fly   621 AELSAATQNLENVLDSII 638
            .:|.:..|.:.....:::
Human   552 MDLYSGAQRVCRAFSALV 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EF-hand_2	44..168	CDD:286194	27/129 (21%)
dah	NP_511162.1	ZZ_dah	281..329	CDD:239085	15/47 (32%)
DYTN	NP_001087199.1	EF-hand_2	9..118	CDD:286194	24/125 (19%)
		EF-hand_3	125..217	CDD:286195	21/111 (19%)
		ZZ_dystrophin	226..274	CDD:239074	15/47 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..475		18/104 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I5405
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12268
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.920