DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dah and Utrn

DIOPT Version :9

Sequence 1:	NP_511162.1	Gene:	dah / 32459	FlyBaseID:	FBgn0015926	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_006227699.1	Gene:	Utrn / 25600	RGDID:	3947	Length:	3424	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	129/619 - (20%)
Similarity:	220/619 - (35%)	Gaps:	144/619 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117
            |..|.:::.||.|.|...|||......:.......:..:|.|:...:|:..| .:.:.|...|..
  Rat  2846 DLNNVRFSAYRTAIKIRRLQKALCLDLLELNTTNEVFKQHKLNQNDQLLSVP-DVINCLTTTYDG 2909

  Fly   118 CEKLGHFNQD-ANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCK-LYSSDHLVGDI 180
            .|:|   ::| .|..|  ...:..|:..||||..|...|.:..::|..:.|.| |....:..  :
  Rat  2910 LEQL---HKDLVNVPL--CVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRC--L 2967

  Fly   181 FGLLADPKSQIISRYAFEQLLATLSKLLSYLGEAKAYGVHNLPLAMEQCFARCPHGVGGLTEPQF 245
            |..:|.| :::..:.....||....::...|||..|:|..|:..::..||.:      ...:|:.
  Rat  2968 FKEVAGP-TEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQ------NNNKPEI 3025

  Fly   246 HKL----WTGAGVQTRFLIYGNLLALVKRIEDTEHLIHSNSCAGCRKEHIVGIRFRCQVCRDISL 306
            ...    |  ..::.:.:::   |.::.|:...|...|...|..|::..|||.|:|.....:..:
  Rat  3026 SVKEFIDW--MRLEPQSMVW---LPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDV 3085

  Fly   307 CLPCFAVGFAGGRHEPGHRMCEVFVEDQPPLRWTRHLARLCGWLVMPRKTQEEERRGFCNAQES- 370
            |..|    |..||...||::....||...|                  .|..|:.|.|....::
  Rat  3086 CQSC----FFSGRTAKGHKLHYPMVEYCIP------------------TTSGEDVRDFTKVLKNK 3128

  Fly   371 ---------GPAL----------GQSAATPI-----------PAETRSVRSQCQEKDRTVVLQQQ 405
                     .|.|          |.:..|||           |:::    .|....|....::|.
  Rat  3129 FRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQS----PQLFHDDTHSRIEQY 3189

  Fly   406 QQELCSLT----GLASEASSRLQSIIDRLLLQNAKLETQLQTVATASSSEISQFLSAHQCF---- 462
            ...|..:.    ...:::||...|:.|    ::|.::...||:  ...|.:||..|..|..
  Rat  3190 ATRLAQMERTNGSFLTDSSSTTGSVED----EHALIQQYCQTL--GGESPVSQPQSPAQILKSVE 3248

  Fly   463 ------LLQIIEDMRQ----------------LSHASAVTSPPPAPAAQVAPSA-APLVSSTFLS 504
                  |.:||.|:.:                |.....:.|||.:..:....|. :.|::...|.
  Rat  3249 KEERGELERIIADLEEEQRNLQVEYEQLKEQHLRRGLPLGSPPDSIVSPYHTSEDSELIAEAKLL 3313

  Fly   505 SSTPQR-----QMLFDMYAPVGANLTHSINGADLNRSYLEANKSDYSLNDISLWFDQRRS----S 560
            .....|     |:|.|....:.:.| |.:      |..||...||..:|.:|.|...:..    |
  Rat  3314 RQHKGRLEARMQILEDHNKQLESQL-HRL------RQLLEQPDSDSRINGVSPWASPQHPSLSYS 3371

  Fly   561 VQPGQGPGS--------LPAPLPLPMPLGALLEQ 586
            :.|..||.|        |..|......|..::||
  Rat  3372 LDPDPGPQSHQAASEDLLAPPHDTSTDLTDVMEQ 3405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EF-hand_2	44..168	CDD:286194	28/115 (24%)
dah	NP_511162.1	ZZ_dah	281..329	CDD:239085	14/47 (30%)
Utrn	XP_006227699.1	CH	37..140	CDD:237981
		CH	156..260	CDD:237981
		SPEC	315..533	CDD:238103
		SPEC	548..>651	CDD:295325
		SPEC	696..909	CDD:238103
		SPEC	808..1020	CDD:238103
		SPEC	917..1128	CDD:295325
		SPEC	1137..1341	CDD:238103
		SPEC	1240..1451	CDD:238103
		SPEC	1552..1750	CDD:295325
		SPEC	1972..2174	CDD:238103
		SPEC	2222..2434	CDD:238103
		SPEC	2442..2682	CDD:238103
		SPEC	2684..>2800	CDD:238103
		WW	2809..2837	CDD:238122
		EF-hand_2	2838..2956	CDD:286194	28/115 (24%)
		EF-hand_3	2960..3051	CDD:286195	17/104 (16%)
		ZZ_dystrophin	3060..3108	CDD:239074	15/51 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810