Protein Alignment dah and DMD

DIOPT Version :10

• Sequence 1: NP_511162.1
• Gene: dah / 32459
• FlyBaseID: FBgn0015926
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_006724531.1
• Gene: DMD / 1756
• HGNCID: 2928
• Length: 3703
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 134/630 - (21%)
• Similarity: 210/630 - (33%)
• Gaps: 175/630 - (27%)

  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117
            |..|.:::.||.|.|...|||......:........||:|||....:.| ...|:.:.|..:|..
Human  3097 DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPM-DILQIINCLTTIYDR 3160

  Fly   118 CEKLGHFNQDANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCKLYSSDHLVGDIFG 182
            .|:  ..|...|..|  ...:..|:..||||..|...|.:|..:...|.|||.:..|..
Human  3161 LEQ--EHNNLVNVPL--CVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKY------ 3215

  Fly   183 LLADPKSQIISRYAFEQLLAT--------LSKLL-------SYLGEAKAYGVHNLPLAMEQCFA- 231
                       ||.|:|:.::        |..||       ..|||..::|..|:..::..||.
Human  3216 -----------RYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQF 3269

  Fly   232 --RCPHGVGGL------TEPQFHKLWTGAGVQTRFLIYGNLLALVKRIEDTEHLIHSNSCAGCRK 288
              ..|.....|      .||| ..:|               |.::.|:...|...|...|..|::
Human  3270 ANNKPEIEAALFLDWMRLEPQ-SMVW---------------LPVLHRVAAAETAKHQAKCNICKE 3318

  Fly   289 EHIVGIRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPL---RWTRHLARLCGWL 350
            ..|:|.|:|.....:..:|..|    |..||...||:|....||...|.   ...|..|::.
Human  3319 CPIIGFRYRSLKHFNYDICQSC----FFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVL--- 3376

  Fly   351 VMPRKTQEEERRGFCNAQESG--PAL----GQSAATPI------PAETRSVRSQCQEKDRTVVLQ 403
                |.:...:|.|......|  |..    |.:..||:      |.::....|.....|.|
Human  3377 ----KNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDT---- 3433

  Fly   404 QQQQELCSLTGLASEASSRLQSIIDRLL-LQNAKLETQLQTVATASSSEISQFLSAHQCFLLQII 467
                            .||::....||. ::|:.......:::...|.:....|..|.|
Human  3434 ----------------HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYC------ 3476

  Fly   468 EDMRQLSHASAVTSPPPAPAAQVAPSAAPLVSSTFLSSSTPQRQMLFDMYAPVGANLTHSINGAD 532
                |..:..:..|.|.:||                       |:|..:.:.....|...:  ||
Human  3477 ----QSLNQDSPLSQPRSPA-----------------------QILISLESEERGELERIL--AD 3512

  Fly   533 LNRSYLEANKSDYSLNDISLWFDQRRSSVQPGQGPGSLPAPLPLPMPLGALLEQQPANGGDGRDT 597
            |.    |.|:      ::...:|:.:   |..:..|..|.|.|   |     |..|.:....||.
Human  3513 LE----EENR------NLQAEYDRLK---QQHEHKGLSPLPSP---P-----EMMPTSPQSPRDA 3556

  Fly   598 EMVNFKLLLHKVK-------EIVEDSYSDNAELSAATQNLENVLD 635
            |::....||.:.|       :|:||   .|.:|.:....|..:|:
Human  3557 ELIAEAKLLRQHKGRLEARMQILED---HNKQLESQLHRLRQLLE 3598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EFh_DAH	81..250	CDD:320003	45/192 (23%)
		EF-hand-like motif	81..120	CDD:320003	9/38 (24%)
		EF-hand-like motif	132..166	CDD:320003	9/33 (27%)
		EF-hand-like motif	173..210	CDD:320003	8/51 (16%)
		EF-hand-like motif	223..250	CDD:320003	7/35 (20%)
		ZZ_dah	281..329	CDD:239085	14/47 (30%)
DMD	XP_006724531.1	CH_DMD_rpt1	11..121	CDD:409080
		CH_DMD_rpt2	136..246	CDD:409082
		SPEC	341..558	CDD:238103
		SPEC	560..827	CDD:413338
		235kDa-fam	<763..>1938	CDD:130673
		SPEC	1049..1263	CDD:238103
		SPEC	1878..2102	CDD:413338
		SPEC	2105..2320	CDD:238103
		SPEC	2321..2579	CDD:413338
		SPEC	2472..2688	CDD:238103
		SPEC	2690..2933	CDD:238103
		Spectrin	2934..3040	CDD:395348
		WW	3059..3088	CDD:238122
		EFh_DMD	3125..3286	CDD:320004	42/182 (23%)
		EF-hand-like motif	3125..3164	CDD:320004	10/41 (24%)
		EF-hand-like motif	3171..3205	CDD:320004	9/35 (26%)
		EF-hand-like motif	3211..3247	CDD:320004	8/52 (15%)
		EF-hand-like motif	3260..3286	CDD:320004	4/25 (16%)
		ZZ_dystrophin	3311..3359	CDD:239074	15/51 (29%)