DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dah and Drp2

DIOPT Version :9

Sequence 1:	NP_511162.1	Gene:	dah / 32459	FlyBaseID:	FBgn0015926	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_006528559.1	Gene:	Drp2 / 13497	MGIID:	107432	Length:	981	Species:	Mus musculus

Alignment Length:	469	Identity:	106/469 - (22%)
Similarity:	171/469 - (36%)	Gaps:	110/469 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117
            |..|.|::.||.|.|...:||......:.....|.|.:.|:|.....:|    .:..::|.:...
Mouse   418 DLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVM----DVVEVIHCLTAL 478

  Fly   118 CEKLGHFNQDANYKLDRATGLLA----------NFFWNVYDPQRRHSISLLEIRITFILLCKLYS 172
            .|           :|:...|:|.          |:..||:|..|...:..|..:.....||....
Mouse   479 YE-----------RLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEV 532

  Fly   173 SDHLVGDIFGLLADPKSQIISRYAFEQLLATLSKLLSYLGEAKAYGVHNLPLAMEQCFARCPHGV 237
            .:.| ..:|..:|:..||...|: ...||....::...|||..|:|..|:..::..||
Mouse   533 KEKL-QYLFSQVANSGSQCDQRH-LGALLHEAIQVPRQLGEVAAFGGSNVEPSVRSCF------- 588

  Fly   238 GGLTEPQFHKLWTGAGV--QTRFLIYGNL-------LALVKRIEDTEHLIHSNSCAGCRKEHIVG 293
                     :..||..|  .::||.:.||       ||::.|:...|.:.|...|:.||:..|.|
Mouse   589 ---------RFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPIKG 644

  Fly   294 IRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPLRWTRHLARLCGWLVMPRKTQE 358
            .|:|.....::.:|..||..    ||...|:::....:|...|                  .|..
Mouse   645 FRYRSLKQFNVDICQTCFLT----GRASKGNKLHYPIMEYYTP------------------TTSS 687

  Fly   359 EERRGFCNAQESGPALGQSAATPIPAETRSVRSQCQEKDRTVV-LQQQQQELCSLTGLAS----- 417
            |..|.|              ||.:..:.||.:...:...|..: :|...:..||.|..:|
Mouse   688 ENMRDF--------------ATTLKNKFRSKQYFSKHPQRGYLPVQSVLESDCSETPASSPMLPH 738

  Fly   418 -EASSRLQSIIDRLLLQNAKLETQLQTVATASSSEISQFLSAHQCFLLQIIEDMRQLSHASAVTS 481
             :..||::....||    |::|:|       :.|..:..||...    .|.||...|.|:|.:|.
Mouse   739 ADTHSRIEHFASRL----AEMESQ-------NCSFFNDSLSPDD----SIDEDQYLLRHSSPITD 788

  Fly   482 PPPAPAAQVAPSAA 495
            ..||...|...|.|
Mouse   789 REPAFGQQAPCSMA 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dah	NP_511162.1	EF-hand_2	44..168	CDD:286194	25/124 (20%)
dah	NP_511162.1	ZZ_dah	281..329	CDD:239085	13/47 (28%)
Drp2	XP_006528559.1	SPEC	135..363	CDD:238103
		WW	381..409	CDD:238122
		EFh_DRP-2	446..607	CDD:320006	39/193 (20%)
		EF-hand-like motif	446..484	CDD:320006	8/52 (15%)
		EF-hand-like motif	492..526	CDD:320006	6/33 (18%)
		EF-hand-like motif	532..568	CDD:320006	8/37 (22%)
		EF-hand-like motif	581..607	CDD:320006	7/41 (17%)
		ZZ_dystrophin	632..680	CDD:239074	13/51 (25%)
		SMC_prok_A	<740..906	CDD:274009	22/78 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12268
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910