DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top1 and top1mt

DIOPT Version :9

Sequence 1:NP_001014742.1 Gene:Top1 / 32458 FlyBaseID:FBgn0004924 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_031759708.1 Gene:top1mt / 779551 XenbaseID:XB-GENE-962427 Length:1149 Species:Xenopus tropicalis


Alignment Length:1003 Identity:454/1003 - (45%)
Similarity:596/1003 - (59%) Gaps:126/1003 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 VAAEN-SIHIQNGG-SCEVVQSNGVTTNGHGHHHHHHHSSSSSSSSKHKSSSKDKHRDREREHKS 67
            ::.:| :|..|.|| .|:..:..      .|||           .||.|..:.|: .:|:::|..
 Frog   240 ISKDNRNIQEQKGGLPCKTEKER------DGHH-----------KSKVKKDNVDR-SERKKDHVE 286

  Fly    68 SNSSSSSKEHKSSSRDKDRHKSSSSSSKHRDKDKERDGSSNSHRSGSSSSHKDKDGS-------- 124
            .:..|..|| |..|..|:|.|:.........|:..:.|..|..   |.|..|..||:        
 Frog   287 KSGDSEKKE-KGDSEKKERGKNHLCRDSEGGKESLKRGKENKE---SKSEQKAIDGTEGIAQPER 347

  Fly   125 -SSSKHKSSSGHHKRSSKDKE--RRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSSSSSSSK 186
             ...:.|.:||..:.|:::||  :||..|.:..:|:...:.......||:|...:::......:|
 Frog   348 EKKCEDKMASGKERESAEEKETGKRDPLKSKDKTSAGEERKPKKHSHKEKSKEMNRTREKMEDAK 412

  Fly   187 SKHSSSRHSSSSSSKDQPSYDGVFVKPE----PVSQQLMHSGSVDAFQMQQLGSYEAAAAGTNFN 247
            ...|...|....:.:.....:.. ||||    .|.:...||..||                    
 Frog   413 MSVSRDHHRKGDALEGAVEANEA-VKPERIEVAVGEPKEHSREVD-------------------- 456

  Fly   248 GNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDST 312
                          |:..:.:|..||..|.|   ::.....|:.:..|.. ..|||:.       
 Frog   457 --------------EKVHLRVKSFEEELNEL---ANLKMQSSKVKKKERE-TKKHEEK------- 496

  Fly   313 MNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESK 377
                                   ..|.|::::|..:|.....:.::..|:..:  .|.:::|..|
 Frog   497 -----------------------REKIKEQSSDGAEGKATKREGEEEELVGEE--AKPRVEKNQK 536

  Fly   378 EKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKW 442
            ||.|:|.|:...|:....|.:..:.:|..|...:..|:.|..||.|||..|:|||||...||:||
 Frog   537 EKIKERGKKSSKDEAARDKKQPSRKRKSTETEGTEAKKAKDAAKKEEESKWKWWEEEHYEDGMKW 601

  Fly   443 STLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDF 507
            ..|||:||.|||.||.:|.:|.|||||||::||...||.||||.|||:|:|.|||.|..|||.|:
 Frog   602 KFLEHRGPYFAPPYEPLPDDVSFYYDGKPVKLSPGAEEVATFYGKMLDHEYTTKEAFQKNFFADW 666

  Fly   508 RKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHK 572
            |:.||..||::||...||.|.|:..||..::|.|||..||||...|.|...:.:|:|:|::|||:
 Frog   667 REQMTNEERKLIKHLHKCEFSEIHKYFFEKNEARKALPKEEKQKLKEETNKIQEEYGYCILDGHR 731

  Fly   573 EKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTW 637
            ||||||::||||||||||:||||||:|.||...||.|||.|:||||.||||.:|||||.||||||
 Frog   732 EKIGNFKIEPPGLFRGRGDHPKMGMLKLRIMPEDVIINCSKESKVPDPPPGHKWKEVRCDNTVTW 796

  Fly   638 LASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAV 702
            ||||.||:|..:||||||||||||||||..||||||||..|:..|||.||.:|||:||:.|||||
 Frog   797 LASWTENIQSSIKYIMLNPSSKLKGEKDWQKYETARRLKGVVSDIRAQYRVDWKSREMKKRQRAV 861

  Fly   703 ALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVE 766
            ||||||||||||||||:| :.|||||||||||||:||:.||:|::.||.|||.|||||||||:|.
 Frog   862 ALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIQLYPELDGQQYVVEFDFLGKDSIRYYNKVP 926

  Fly   767 VEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTD 831
            |||.|||||:||||:|...|||||||||.:||:||::||:|||||||||||||.|||:||..||:
 Frog   927 VEKEVFKNLKLFMENKNPEDDLFDRLNTSILNKHLQDLMDGLTAKVFRTYNASITLQNQLKELTN 991

  Fly   832 PSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYHSRD--- 893
            ....|..|:|:|||||||||:||||||:.||:.||||:||:.||.||.:.:::.:.|..|..   
 Frog   992 GEDNVAAKILSYNRANRAVALLCNHQRAPPKTFEKSMQNLQTKIDAKEQQLKEAKKELKSAKAEH 1056

  Fly   894 ------------EKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHD 946
                        |||.||:.|:.:||.||:||.||::|||.|||||||||||||||:||||||:.
 Frog  1057 KARKSEKSKKEMEKKKKQVARIEEQLMKLKLQATDKEENKQIALGTSKLNYLDPRITVAWCKKYG 1121

  Fly   947 VPIEKIFNKTQRTKFLWAVHMADENYRF 974
            ||||||:|||||.||.||:.|..||:.|
 Frog  1122 VPIEKIYNKTQREKFAWAIDMTSENFEF 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top1NP_001014742.1 Topoisomer_IB_N_htopoI_like 441..655 CDD:239570 132/213 (62%)
TOPEUc 585..946 CDD:214661 255/376 (68%)
Topoisom_I 657..859 CDD:279380 148/202 (73%)
Topo_C_assoc 905..972 CDD:291068 49/66 (74%)
top1mtXP_031759708.1 PTZ00121 <65..>566 CDD:173412 83/418 (20%)
Topoisom_I_N 599..813 CDD:397183 131/213 (62%)
TOPEUc 744..1121 CDD:214661 255/376 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 331 1.000 Domainoid score I1157
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 822 1.000 Inparanoid score I459
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D208288at33208
OrthoFinder 1 1.000 - - FOG0001157
OrthoInspector 1 1.000 - - otm49460
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X783
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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