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Protein Alignment Top1 and Top1mt

DIOPT Version :9

Sequence 1:	NP_001014742.1	Gene:	Top1 / 32458	FlyBaseID:	FBgn0004924	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_082680.1	Gene:	Top1mt / 72960	MGIID:	1920210	Length:	593	Species:	Mus musculus

Alignment Length:	559	Identity:	331/559 - (59%)
Similarity:	413/559 - (73%)	Gaps:	16/559 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 WEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCT 495
            |||..:: .|||..||||||.|.|.||.:|..|.|.||||||:||...||.||||.|||:.:..:
Mouse    36 WEETSKS-SVKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKMLHLECTS 99

  Fly   496 KEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALM 560
            ||||..|||.|:||.|||.||.:|....||:|.|:..:|...:|.|:...:|:|...|.|.|.|.
Mouse   100 KEVFRRNFFSDWRKEMTPEERRLITHLDKCDFTEIHKHFLERAEARRTLPREQKQKLKEEAEKLQ 164

  Fly   561 KEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSR 625
            :|||:|::|||:||||||:.||||||||||:||||||:|||:...||.|||.:|||:|.||.|.:
Mouse   165 QEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSKIPEPPAGHQ 229

  Fly   626 WKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEW 690
            |||||.||||.|||:|:|::|...||::||||||.|||.|..|||.||||..|:|||||.|:.:|
Mouse   230 WKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYEVARRLKGVVDKIRAQYQADW 294

  Fly   691 KSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNGKENVVVFDFP 754
            ||.||:.||.|||||||||||||.||||:| :.|||||||||||||::||....|:|:||..||.
Mouse   295 KSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHIRLHAPAGGQEHVVELDFL 359

  Fly   755 GKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNAS 819
            |||||||.|.|.|||.||:||:.|||.|...|||||.|.|..||:||::||||||||||||||||
Mouse   360 GKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSLNKHLQDLMEGLTAKVFRTYNAS 424

  Fly   820 KTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKR----E 880
            .|||.||.:||....:|..|:|||||||||||:||||||:|||:.||||:.|::||:.|:    |
Mouse   425 VTLQEQLRVLTRAEDSVTCKVLAYNRANRAVAVLCNHQRAVPKTFEKSMQTLQKKIETKKAQVAE 489

  Fly   881 A---IEKCESEYHSRDEKKGK-------QLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDP 935
            |   ::|.|::...|.:.|.|       :|.:|.:||.:|..:.||::|||.:||||:|||||||
Mouse   490 AQVELQKAETDLRMRGDSKPKSFLQKQRRLLKLEEQLARLCAKATDKEENKQVALGTAKLNYLDP 554

  Fly   936 RISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974
            |||:||||:..||:|||:|||||.:|.||.:.|.|::.|
Mouse   555 RISIAWCKRFGVPVEKIYNKTQRERFAWAFNQAGEDFEF 593

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.