DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top1 and top1a

DIOPT Version :9

Sequence 1:NP_001014742.1 Gene:Top1 / 32458 FlyBaseID:FBgn0004924 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_001037789.1 Gene:top1a / 553496 ZFINID:ZDB-GENE-060616-217 Length:758 Species:Danio rerio


Alignment Length:954 Identity:460/954 - (48%)
Similarity:569/954 - (59%) Gaps:216/954 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 HHHHSSSSSSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSKHRDKDK 101
            |.|:.|...|.|:|..|.|.|.:.:::|||          ||...:||:|.||..|:|:|     
Zfish     5 HSHNDSQIDSGSRHNDSHKHKDKYKDKEHK----------HKDHKKDKEREKSKYSNSEH----- 54

  Fly   102 ERDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSRHKSSSSS 166
             ||.|...||.......|.|||||                     ||.||       :||   ..
Zfish    55 -RDSSEKKHRDKDKERQKLKDGSS---------------------DKQKD-------KHK---EK 87

  Fly   167 RDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSGSVDAFQM 231
            |.:||||.........:...|.|                     :|.||.|....||..::.   
Zfish    88 RKEERSSDDRPKKEKQNGFASPH---------------------IKSEPDSDDFYHSPKLEK--- 128

  Fly   232 QQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEP 296
                                               .:|:|.                        
Zfish   129 -----------------------------------SLKRER------------------------ 134

  Fly   297 PFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPL 361
                                                                   |:||.|..| 
Zfish   135 -------------------------------------------------------DDDDGDYKP- 143

  Fly   362 LARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEE 426
               ||:|.|..:.|.|.|.:|:.:|:       :|||||...|:.|.| :.||:   |||.|.||
Zfish   144 ---KKIKTEDDRSEKKAKKRKQEEED-------IKPKKKTKDKKGEVA-TDGKK---KAKKEPEE 194

  Fly   427 VWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNH 491
            .|:|||||:..|||||..||||||||||.||.:|.||:||||||.::||...||.|||::|||:|
Zfish   195 KWKWWEEERYTDGVKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDH 259

  Fly   492 DYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNEN 556
            :|.||::|..|||||:||.||..|:..|.|..||:|..|..||:|:||.|||.:|||||..|.||
Zfish   260 EYTTKDIFRKNFFKDWRKEMTSEEKSKITDLNKCDFSNMSEYFKAQSEARKAMTKEEKLKIKEEN 324

  Fly   557 EALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPP 621
            |.:::|:|||::|.|||:|.|||:||||||||||:||||||:||||:..|:.|||.||||.|:||
Zfish   325 ERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPTPP 389

  Fly   622 PGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATY 686
            ||::||||||||.||||.||.||:||.:|||||||||::|||||..||||||||.|.:|:||:.|
Zfish   390 PGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDRIRSQY 454

  Fly   687 RDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNGKENVVV 750
            ||:||||||::|||||||||||||||||||||:| :.|||||||||||||:.||.|::|:|.||.
Zfish   455 RDDWKSKEMKIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHLTLHPEMDGQEFVVE 519

  Fly   751 FDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRT 815
            |||.|||||||||:|.|||||||||:||||.|:..|||||||||.:||:||:|||:|||||||||
Zfish   520 FDFLGKDSIRYYNKVPVEKRVFKNLQLFMEDKEPEDDLFDRLNTSILNKHLQELMDGLTAKVFRT 584

  Fly   816 YNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKRE 880
            ||||.|||.||:.||:....||.|:|:||||||||||||||||:.||:.||||:||:.||.||:|
Zfish   585 YNASITLQQQLNELTNSEDNVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMQNLQTKIDAKKE 649

  Fly   881 AIEKCESEYHS--------RDEK-------KGKQLERLRDQLKKLELQETDRDENKTIALGTSKL 930
            .:.:.:.|...        :|||       |.|.|:|:.:||.|||:|.|||:|||.||||||||
Zfish   650 QLVEAKRELKGAKADAKVRKDEKFKKAVEAKKKALQRVEEQLMKLEVQATDREENKQIALGTSKL 714

  Fly   931 NYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974
            ||||||||||||||..:|||||:|||||.||.||:.||:::|.|
Zfish   715 NYLDPRISVAWCKKFGIPIEKIYNKTQREKFAWAIDMAEKDYEF 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top1NP_001014742.1 Topoisomer_IB_N_htopoI_like 441..655 CDD:239570 138/213 (65%)
TOPEUc 585..946 CDD:214661 262/376 (70%)
Topoisom_I 657..859 CDD:279380 152/202 (75%)
Topo_C_assoc 905..972 CDD:291068 50/66 (76%)
top1aNP_001037789.1 Topoisom_I_N 208..422 CDD:280987 138/213 (65%)
TOPEUc 353..730 CDD:214661 262/376 (70%)
Topoisom_I 425..628 CDD:279380 152/202 (75%)
Topo_C_assoc 688..756 CDD:291068 50/67 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 334 1.000 Domainoid score I1104
eggNOG 1 0.900 - - E1_COG3569
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2467
Inparanoid 1 1.050 827 1.000 Inparanoid score I445
OMA 1 1.010 - - QHG62324
OrthoDB 1 1.010 - - D208288at33208
OrthoFinder 1 1.000 - - FOG0001157
OrthoInspector 1 1.000 - - otm24282
orthoMCL 1 0.900 - - OOG6_101409
Panther 1 1.100 - - O PTHR10290
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X783
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.840

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