DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top1 and zgc:173742

DIOPT Version :9

Sequence 1:	NP_001014742.1	Gene:	Top1 / 32458	FlyBaseID:	FBgn0004924	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_002665372.2	Gene:	zgc:173742 / 334557	ZFINID:	ZDB-GENE-030131-6489	Length:	735	Species:	Danio rerio

Alignment Length:	741	Identity:	394/741 - (53%)
Similarity:	502/741 - (67%)	Gaps:	56/741 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 EESFN---NLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMN---DDEE 330
            ||:|:   ...:|.:...:.||....|.    .|.:..|.|:..|......|....:|   :.:|
Zfish    13 EEAFSEKPKKMKAKAKGKTKSQREGKEK----THRKMKASEEEIMETEGSGDRRSHVNVKEEPKE 73

  Fly   331 DVPLA------MRKRKQEATDRPDGGMDNDDDDDIPLLARKKV---------KKEKIKKESKEKS 380
            |....      .||||.:.||    |:.:..:..:|...:|||         .|:|..||.|||.
Zfish    74 DPDFVTEKKGKKRKRKADNTD----GLLSSAEAPLPKKKKKKVADGQENASTAKQKKMKEKKEKV 134

  Fly   381 KKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEE-EVWRWWEEEKRADGVKWST 444
            ||...|.|      |..||||.|:|.|.|    :..|.|.|.||| :.||||||||..:|:||..
Zfish   135 KKEEGERP------VSTKKKKTKEEIEAA----RALKIKKKEEEEKQRWRWWEEEKYENGIKWKF 189

  Fly   445 LEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRK 509
            ||||||.|.|.|:.:|.:|:|||:|:|::||...||.|.::|:||:|:|.|||||.||||||:||
Zfish   190 LEHKGPYFPPAYQPLPDDVKFYYNGEPVKLSLPAEEVALYFAQMLDHEYTTKEVFRNNFFKDWRK 254

  Fly   510 SMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHKEK 574
            .||..||::|.|.:||:|.|:....:.:.|.||..||||||:.|..|:.::.|:|||::|.|:|:
Zfish   255 EMTLEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKEEKLVNKEANQKIVDEYGFCVLDHHRER 319

  Fly   575 IGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTWLA 639
            ||||::||||||||||:|||.||:|:||:..||.|||.|:|::|..|.|.:|||||||.||||||
Zfish   320 IGNFKIEPPGLFRGRGDHPKQGMLKKRIRPEDVIINCSKESRIPEAPAGHKWKEVRHDKTVTWLA 384

  Fly   640 SWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVAL 704
            ||.|||||..||:|||.:||||||||..|||.||:|...:|.||..|:::.|||:|..|||||||
Zfish   385 SWTENVQGSCKYVMLNANSKLKGEKDWEKYEVARKLKTCVDAIRTQYQEDLKSKQMGTRQRAVAL 449

  Fly   705 YFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVE 768
            ||||||||||||||:| :.|||||||||||||:.||..|:.::.||.|||.|||.|||||:|.|.
Zfish   450 YFIDKLALRAGNEKEEGETADTVGCCSLRVEHITLHDALDDQKCVVEFDFLGKDCIRYYNKVPVT 514

  Fly   769 KRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPS 833
            |||||||:||||:|:.||||||||||..||:||..||.|||||||||||||.|||.||..|::..
Zfish   515 KRVFKNLKLFMENKQGGDDLFDRLNTASLNKHLSSLMPGLTAKVFRTYNASITLQQQLKELSNMK 579

  Fly   834 ATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYH-------- 890
            ..||||||:|||||||||:||||||:.|||.::||.||:.||.:::|.::..:.|..
Zfish   580 DNVPEKLLSYNRANRAVAVLCNHQRAPPKSFDQSMANLQAKIDSRKEQLDLAKKELKQAKKEAKG 644

  Fly   891 SRD-------EKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVP 948
            |.|       |||.|.::|..:||.|:|:|.|||:|||.|||.|||||||||||||||||..:||
Zfish   645 SSDNKLLVVVEKKKKAVQRCEEQLLKMEVQATDREENKQIALSTSKLNYLDPRISVAWCKNMEVP 709

  Fly   949 IEKIFNKTQRTKFLWAVHMADENYRF 974
            ::||:|||.|.||.|||.|.:.::.|
Zfish   710 LDKIYNKTLRDKFAWAVDMTELDFVF 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top1	NP_001014742.1	Topoisomer_IB_N_htopoI_like	441..655	CDD:239570	124/213 (58%)
		TOPEUc	585..946	CDD:214661	241/376 (64%)
		Topoisom_I	657..859	CDD:279380	142/202 (70%)
		Topo_C_assoc	905..972	CDD:291068	45/66 (68%)
zgc:173742	XP_002665372.2	Topoisom_I_N	185..399	CDD:280987	123/213 (58%)
		TOPEUc	330..704	CDD:214661	239/373 (64%)
		Topoisom_I	402..605	CDD:279380	142/202 (70%)
		Topo_C_assoc	665..733	CDD:291068	45/67 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1104
eggNOG	1	0.900	-	-		E1_COG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62324
OrthoDB	1	1.010	-	-		D208288at33208
OrthoFinder	1	1.000	-	-		FOG0001157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101409
Panther	1	1.100	-	-	O	PTHR10290
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.790