DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top1 and top1

DIOPT Version :9

Sequence 1:NP_001014742.1 Gene:Top1 / 32458 FlyBaseID:FBgn0004924 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_596209.1 Gene:top1 / 2540032 PomBaseID:SPBC1703.14c Length:814 Species:Schizosaccharomyces pombe


Alignment Length:943 Identity:344/943 - (36%)
Similarity:463/943 - (49%) Gaps:234/943 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 SHKDKDG-SSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSS 180
            |..|.|. |.|.:.:...|..||.|.      |:.|..|.||..|..|.|...|.:|.|   ...
pombe     2 SSSDSDSVSLSIRRRQRRGSSKRISM------KESDEESDSSENHPLSESLNKKSKSES---DED 57

  Fly   181 SSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSGSVDAFQMQQLGSYEAAAAGTN 245
            .....|.:.||.::.|:||||.:                                        ..
pombe    58 DIPIRKRRASSKKNMSNSSSKKR----------------------------------------AK 82

  Fly   246 FNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEED 310
            ..|||.:     |||.:.::|   ||||.||.:::.|.                 ||::      
pombe    83 VMGNGGL-----KNGKKTAVV---KEEEDFNEIAKPSP-----------------KHKR------ 116

  Fly   311 STMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKE 375
                       ..:.|..:.....|::|.            ::|.||.:||.|...|.....|.|
pombe   117 -----------VSKANGSKNGAKSAVKKE------------ESDTDDSVPLRAVSTVSLTPYKSE 158

  Fly   376 SKEKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGV 440
            ....:.......|:|:                              .:|:|.::||..|...|..
pombe   159 LPSGASTTQNRSPNDE------------------------------EDEDEDYKWWTSENIDDTQ 193

  Fly   441 KWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFK 505
            ||:||||.|.:|||.||.:|:||:..|||.|:.|..|.||.|.|||.||..|:....||.:|||:
pombe   194 KWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLPPEAEEVAGFYAAMLETDHAKNPVFQDNFFR 258

  Fly   506 DFRKSMTP-REREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMID 569
            ||.|.... .....||:|.||:|.:||::|:.:.|::|:..||:|...|.:.:...:::.:|::|
pombe   259 DFLKVCDECNFNHNIKEFSKCDFTQMFHHFEQKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILD 323

  Fly   570 GHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNT 634
            |.|||:||||:||||||||||.|||.|.:|||:....::||.|:...||.|.||.:|.||:||||
pombe   324 GRKEKVGNFRIEPPGLFRGRGSHPKTGSLKRRVYPEQITINIGEGVPVPEPLPGHQWAEVKHDNT 388

  Fly   635 VTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQ 699
            |||||:|.||:...|||:.|...|.|||:.|..|||.:|:|...||.||..||.:.||:....||
pombe   389 VTWLATWHENINNNVKYVFLAAGSSLKGQSDLKKYEKSRKLKDYIDDIRKGYRKDLKSELTVERQ 453

  Fly   700 RAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNE 764
            |..|:|.||..||||||||.||:||||||||||.|||.|.     ....|||||.||||||||||
pombe   454 RGTAMYLIDVFALRAGNEKGEDEADTVGCCSLRYEHVTLK-----PPRTVVFDFLGKDSIRYYNE 513

  Fly   765 VEVEKRVFKNLELFME-HKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDL 828
            |||:.:|||||::|.. .|||||.:||||:|..||::|..||:||:||||||||||.|:..:|..
pombe   514 VEVDPQVFKNLKIFKRPPKKEGDLIFDRLSTNSLNKYLTSLMDGLSAKVFRTYNASYTMAEELKK 578

  Fly   829 LTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIK----------------- 876
            : ..:.|:.:|:|.||||||.|||||||||||.|:|:..||...|:||                 
pombe   579 M-PKNLTLADKILFYNRANRTVAILCNHQRSVTKNHDVQMERFAERIKALQYQRMRLRKMMLNLE 642

  Fly   877 -----------AKREAI-----------------EKCESEYHSRDEKKG---------------- 897
                       ||.|.|                 ||.:.::...:||..                
pombe   643 PKLAKSKPELLAKEEGITDSWIVKHHETLYELEKEKIKKKFDRENEKLAAEDPKSVLPESELEVR 707

  Fly   898 -------------------------------KQLERLRDQLKKLELQETDRDENKTIALGTSKLN 931
                                           |:|.:|.:::..:..|..|:|||||.||||||:|
pombe   708 LKAADELKKALDAELKSKKVDPGRSSMEQLEKRLNKLNERINVMRTQMIDKDENKTTALGTSKIN 772

  Fly   932 YLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWA 964
            |:|||::.::.|:.||||||:|:||.|.||.||
pombe   773 YIDPRLTYSFSKREDVPIEKLFSKTIRDKFNWA 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top1NP_001014742.1 Topoisomer_IB_N_htopoI_like 441..655 CDD:239570 106/214 (50%)
TOPEUc 585..946 CDD:214661 199/453 (44%)
Topoisom_I 657..859 CDD:279380 119/202 (59%)
Topo_C_assoc 905..972 CDD:291068 33/60 (55%)
top1NP_596209.1 Topoisom_I_N 193..408 CDD:280987 106/214 (50%)
TOPEUc 339..787 CDD:214661 199/453 (44%)
Topoisom_I 412..608 CDD:279380 119/201 (59%)
Topo_C_assoc 745..812 CDD:291068 33/61 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 239 1.000 Domainoid score I466
eggNOG 1 0.900 - - E1_COG3569
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2467
Inparanoid 1 1.050 516 1.000 Inparanoid score I225
OMA 1 1.010 - - QHG62324
OrthoFinder 1 1.000 - - FOG0001157
OrthoInspector 1 1.000 - - oto102107
orthoMCL 1 0.900 - - OOG6_101409
Panther 1 1.100 - - LDO PTHR10290
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2314
SonicParanoid 1 1.000 - - X783
TreeFam 1 0.960 - -
1413.860

Return to query results.
Submit another query.