back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top1 and Top1

DIOPT Version :9

Sequence 1:	NP_001014742.1	Gene:	Top1 / 32458	FlyBaseID:	FBgn0004924	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_033434.2	Gene:	Top1 / 21969	MGIID:	98788	Length:	767	Species:	Mus musculus

Alignment Length:	962	Identity:	473/962 - (49%)
Similarity:	571/962 - (59%)	Gaps:	224/962 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HHHSSSS-------SSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSK 95
            |.|:.|.       :.|.||    ||||:|||..|         |||| ..:||||.||..|:|:
Mouse     5 HLHNDSQIEADFRLNDSHKH----KDKHKDREHRH---------KEHK-KDKDKDREKSKHSNSE 55

  Fly    96 HRDKDKE-RDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSR 159
            |:|.:|: ::.....|:.|||..||||              ||  .:|||||.::|.|.:..:..
Mouse    56 HKDSEKKHKEKEKTKHKDGSSEKHKDK--------------HK--DRDKERRKEEKIRAAGDAKI 104

  Fly   160 HKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSG 224
            .|      :||..                     .||....||:|..||.|..|
Mouse   105 KK------EKENG---------------------FSSPPRIKDEPEDDGYFAPP----------- 131

  Fly   225 SVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMS 289

Mouse   132 ----------------------------------------------------------------- 131

  Fly   290 QFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDND 354
                                                   :||:....|.|            |.|
Mouse   132 ---------------------------------------KEDIKPLKRLR------------DED 145

  Fly   355 DDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKK-KMKKEPEPAVSPGKRQKA 418
            |.|..|    ||:|.|.||||.|.||      |..:|....|||.| |.||..||     ..:|.
Mouse   146 DADYKP----KKIKTEDIKKEKKRKS------EEEEDGKLKKPKNKDKDKKVAEP-----DNKKK 195

  Fly   419 KAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAAT 483
            |.|.|||:.|:|||||:..:|:||..||||||||||.||.:|.:|:||||||.::||.:.||.||
Mouse   196 KPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVAT 260

  Fly   484 FYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEE 548
            |:||||:|:|.|||:|..|||||:||.||..|:..|.:..||:|.:|..||:|:||.||..||||
Mouse   261 FFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEE 325

  Fly   549 KLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGK 613
            ||..|.|||.|:||:|||::|.|:|:|.||::||||||||||.||||||:||||...|:.|||.|
Mouse   326 KLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSK 390

  Fly   614 DSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKV 678
            |:||||||||.:||||||||.||||.||.||:||.:|||||||||::|||||..||||||||.|.
Mouse   391 DAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKC 455

  Fly   679 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKEL 742
            :||||..||::||||||:||||||||||||||||||||||:| :.|||||||||||||:.||.||
Mouse   456 VDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPEL 520

  Fly   743 NGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEG 807
            :|:|.||.|||||||||||||:|.|||||||||:||||:|:..|||||||||.:||:||::||||
Mouse   521 DGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEG 585

  Fly   808 LTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLK 872
            ||||||||||||.|||.||..||.|...||.|:|:||||||||||||||||:.||:.||||.||:
Mouse   586 LTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQ 650

  Fly   873 EKIKAKREAIEKCESEYHS--------RD-------EKKGKQLERLRDQLKKLELQETDRDENKT 922
            .||.||::.:.....:..|        :|       |.|.|.::||.:||.|||:|.|||:|||.
Mouse   651 SKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQ 715

  Fly   923 IALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974
            |||||||||||||||:||||||..||||||:|||||.||.||:.|.||:|.|
Mouse   716 IALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF 767

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.