DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Top1 and top1.2

DIOPT Version :9

Sequence 1:	NP_001014742.1	Gene:	Top1 / 32458	FlyBaseID:	FBgn0004924	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001182621.1	Gene:	top1.2 / 100380116	XenbaseID:	XB-GENE-5814502	Length:	775	Species:	Xenopus tropicalis

Alignment Length:	915	Identity:	433/915 - (47%)
Similarity:	555/915 - (60%)	Gaps:	171/915 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HKSSSRDKDRHKSSSSSSKHRDKDKERDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSK 141
            |....:.:|:.|...|..|...|.|::|....:.:.|.:...:.|:.:.....:    ...:|.|
Frog    15 HNLPEKARDKKKKLKSEPKPEGKAKKKDKGKAAVQDGETQRQRGKENNMPVAEE----REIKSDK 75

  Fly   142 DKERRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSY 206
            .||::.||               |.:.||::||.|                    ....:..|..
Frog    76 RKEKKKKD---------------SKKKKEKNSSEH--------------------CEIQQQDPQT 105

  Fly   207 DGVFVKPEPVSQQLMHSGSVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKE 271
            ..|.||.||                               :.:|:.|.|             ||:
Frog   106 SSVIVKLEP-------------------------------DEDGDFAPA-------------KKQ 126

  Fly   272 EESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAM 336
            .:......|..:.:.|.|:        .||.|                :|||
Frog   127 SKGKKRARQGEAGELSKSK--------KVKLE----------------EDAD------------- 154

  Fly   337 RKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKKK 401
                         |::.:         .|..||:|||||  |.:||..|||     |.:| .|||
Frog   155 -------------GVETE---------TKPQKKKKIKKE--EGNKKPKKEE-----GAIK-AKKK 189

  Fly   402 MKKEPEPAVSPGKRQKAKAKVEEEEV-WRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRF 465
            .::|.|.|.:    .|.|.|.|||:: ||||||||..||:||..|||:||||||.||.:|.:|:|
Frog   190 TQEEKEAAAA----LKLKKKEEEEQMRWRWWEEEKYEDGIKWKFLEHEGPVFAPPYEPLPDSVKF 250

  Fly   466 YYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEM 530
            |||||||.||.:.||.|:|:||||:|:|.|||:|.||:|.|:||.||..||.:|.|..||:|.||
Frog   251 YYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMTLEERMVITDLAKCDFTEM 315

  Fly   531 FNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 595
            |.|::.:.|::|..|||:||..|.|||.|::|:|:|.:|.|:|:||||::|||.||||||:|||.
Frog   316 FTYYKGKMEEKKNKSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQ 380

  Fly   596 GMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKL 660
            ||:|:||...|:.|||.||||:|.||||.:||||||||||||||||.|||||.|||||||.:|||
Frog   381 GMLKKRILPEDIIINCSKDSKIPEPPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKL 445

  Fly   661 KGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQAD 724
            |||||..|||.||:|...:..||.|||:.:|||||:||||||||||||||||||||||:| :.||
Frog   446 KGEKDWEKYEVARKLKHHVVTIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETAD 510

  Fly   725 TVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLF 789
            |||||||||||::|:.||:|.:.||.|||.|||||||||:|.|||:|||||:||||:|:||||||
Frog   511 TVGCCSLRVEHIKLYPELDGDKYVVEFDFLGKDSIRYYNKVPVEKQVFKNLQLFMENKQEGDDLF 575

  Fly   790 DRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILC 854
            |||:|.:||:||:.||||||||||||||||.|||.||..||||..::|.|:|:||||||||||||
Frog   576 DRLSTPLLNKHLQSLMEGLTAKVFRTYNASITLQQQLQELTDPEESMPSKILSYNRANRAVAILC 640

  Fly   855 NHQRSVPKSHEKSMENLKEKI---------------KAKREAIEKCESEYHSRDEKKGKQLERLR 904
            ||||:.||:.::||.|||.||               :||:||.||...:.:...|.|.:.::|..
Frog   641 NHQRAPPKTFDQSMANLKSKIDAKKEQILLAKKELKEAKKEAKEKESEKLNKVVESKKRGVQRAE 705

  Fly   905 DQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMAD 969
            :||.::|:|.|||:|||.|||.||||||||||||||||||..|.:|||:|||.|.||.|||.|.:
Frog   706 EQLMRMEVQATDREENKQIALSTSKLNYLDPRISVAWCKKWTVGLEKIYNKTYRDKFAWAVDMTE 770

  Fly   970 ENYRF 974
            .::.|
Frog   771 TDFIF 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top1	NP_001014742.1	Topoisomer_IB_N_htopoI_like	441..655	CDD:239570	136/213 (64%)
		TOPEUc	585..946	CDD:214661	254/376 (68%)
		Topoisom_I	657..859	CDD:279380	149/202 (74%)
		Topo_C_assoc	905..972	CDD:291068	45/66 (68%)
top1.2	NP_001182621.1	Topoisom_I_N	225..439	CDD:280987	135/213 (63%)
		TOPEUc	370..746	CDD:214661	253/375 (67%)
		Topoisom_I	442..645	CDD:279380	149/202 (74%)
		Topo_C_assoc	705..773	CDD:291068	45/67 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I1157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	822	1.000	Inparanoid score	I459
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208288at33208
OrthoFinder	1	1.000	-	-		FOG0001157
OrthoInspector	1	1.000	-	-		otm49460
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2314
SonicParanoid	1	1.000	-	-		X783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090