DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gce and CLOCK

DIOPT Version :9

Sequence 1:NP_001188593.1 Gene:gce / 32457 FlyBaseID:FBgn0261703 Length:959 Species:Drosophila melanogaster
Sequence 2:NP_001254772.1 Gene:CLOCK / 9575 HGNCID:2082 Length:846 Species:Homo sapiens


Alignment Length:734 Identity:160/734 - (21%)
Similarity:261/734 - (35%) Gaps:236/734 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKH------AFGNSL 337
            |.:||::||.|||:.|..|:||.:|:|..|   |::||:.||:.:...|| ||      :..:.:
Human    36 RVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLR-KHKEITAQSDASEI 96

  Fly   338 MQQ-RP------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHPE 395
            .|. :|      :.|..:::.||.|||.:...|.|:.:|.|:...|.|..|||..|||.... ||
Human    97 RQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFI-PE 160

  Fly   396 DQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGPRSEP 460
            .::....:::.|.|.       :||:......:||.:.:.....||          ....|: ||
Human   161 GEHSEVYKILSTHLL-------ESDSLTPEYLKSKNQLEFCCHMLR----------GTIDPK-EP 207

  Fly   461 TAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRP 525
            :.||.||..|.|:..:....... |.|...:|...|....|.|..:.|:           |:..|
Human   208 STYEYVKFIGNFKSLNSVSSSAH-NGFEGTIQRTHRPSYEDRVCFVATV-----------RLATP 260

  Fly   526 PKIASR-LIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVAL 589
            ..|... .::....|:.:||.::.:.:..|.|...:.||:..||...|.:.:.|.||       |
Human   261 QFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDD-------L 318

  Fly   590 RQMYDCNS---SYGEST---YRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNTLL--GEEEG 646
            ..:..|:.   .||:..   ||..|:....|:||:..|:...:..::....||.:|::  .|...
Human   319 ENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRA 383

  Fly   647 KRRVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQ 711
            :|| :|:                                                  |.|:...:
Human   384 ERR-REL--------------------------------------------------GIEESLPE 397

  Fly   712 DGDDDEEDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSHGHGNAKTPPLALVPPEASSVK 776
            ...|..:|...|......|:.|                 ||....|...         |.|||..
Human   398 TAADKSQDSGSDNRINTVSLKE-----------------ALERFDHSPT---------PSASSRS 436

  Fly   777 SAITKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQGAPTTDLQAVGSNLKR 841
            |  .||                :.|||..|||..:...:|:.:|                     
Human   437 S--RKS----------------SHTAVSDPSSTPTKIPTDTSTP--------------------- 462

  Fly   842 GSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQ----------------------QLN 884
             ...|:...||:.:||...|::     ..:...:|.:|||                      ||.
Human   463 -PRQHLPAHEKMVQRRSSFSSQ-----SINSQSVGSSLTQPVMSQATNLPIPQGMSQFQFSAQLG 521

  Fly   885 VARNLREQ-SQRYELPHANQRFDEIMQEHQKQSELYVNIKSEYEVQLQHK--------------- 933
            ..::|::| .||..:..||        .|::|.||.   |.:.::|:.|.               
Human   522 AMQHLKDQLEQRTRMIEAN--------IHRQQEELR---KIQEQLQMVHGQGLQMFLQQSNPGLN 575

  Fly   934 -ASTRKSSDSDRNQEQPPP 951
             .|.:.||.:..|.:|..|
Human   576 FGSVQLSSGNSSNIQQLAP 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gceNP_001188593.1 HLH 279..325 CDD:238036 20/45 (44%)
PAS 352..>405 CDD:238075 19/52 (37%)
PAS_11 539..646 CDD:291273 28/114 (25%)
CLOCKNP_001254772.1 HLH 32..86 CDD:238036 24/53 (45%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 5/10 (50%)
PAS 109..>175 CDD:307226 21/66 (32%)
PAS_3 274..377 CDD:330807 27/109 (25%)
Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785 371..845 62/357 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..495 25/128 (20%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 28/157 (18%)
Med15 <496..>686 CDD:312941 22/110 (20%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 15/60 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..654
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..783
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..846
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144530
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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