DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and Ncoa2

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_114010.1	Gene:	Ncoa2 / 83724	RGDID:	620108	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	149/836 - (17%)
Similarity:	274/836 - (32%)	Gaps:	276/836 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 GREARNRAEKNRRDKLNGSIQELSTMV----PHVAESPRRVDKTAVLRFAAHALRL-----KHAF 333
            |...:...||..|::.|..|:||:.::    ..:.....:.||.|:|:.....:|.     |.|.
  Rat    27 GPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91

  Fly   334 GNSLMQQRPQITDT-------------LMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYG 385
            .|....|:..::.|             :::.||.||..:...|:::.:|.::.|:|.:.|.:|..
  Rat    92 ANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMN 156

  Fly   386 QSIMQITHPEDQNMLKQQLIPTELEN--------------------LFDAHGDSDAEGEPRQRSK 430
            :|:..|.|..|.....:.|:|..:.|                    |.....||:.||...|.:.
  Rat   157 KSVYSILHVGDHTEFVKNLLPKSMVNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAH 221

  Fly   431 AEEDAID----------RKLREDRRSFRVRLARAGPRSEPTAYEVVKIDGCFRRSDEAPRGVRSN 485
            .:.:.:.          ::..||::|..:.:||..|..                  |.|....|.
  Rat   222 QKYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMK------------------ERPALPSSE 268

  Fly   486 HFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRI 550
            .|::...|    :|:  :..|.|.:..|.:..|...::|      |.|.    ::.|:|
  Rat   269 SFTTRQDL----QGK--ITFLDTSTMRDAMKPGWEDLVR------RCIQ----KFHTQH------ 311

  Fly   551 IDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNIIY 615
                            |..:|| :...|:.:|....:|..|:           ||....:|.::.
  Rat   312 ----------------EGESLS-YAKRHHHEVLRQGLAFSQI-----------YRFSLSDGTLVA 348

  Fly   616 LQSKGYLEIDKETNKVHSFVCVNTLLGEEEGKRRVQEMKKKFSVIINTQIPQSTIDVP----ASE 676
            .|:|..|...:.||:....:.::.|..|:.            ..::|..:....:..|    :|.
  Rat   349 AQTKSKLIRSQTTNEPQLVISIHMLHREQN------------VCVMNPDLTGQAMGKPLSPMSSS 401

  Fly   677 HPALLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQDGDDDEEDDDDDQDDGARSMSEFGDPYGSH 741
            .||          :....||..|        .|...|.:.....:..::..:..|..||...|.:
  Rat   402 SPA----------RQAMCSGNPG--------QDVALGSNMNFPMNGPREQMSMPMGRFGGSGGMN 448

  Fly   742 H---------------------GRSHHG------SSALSSHGH------GNAKTPPLALVPP--- 770
            |                     .:|..|      ||.||....      |:.:.||....|.
  Rat   449 HVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSL 513

  Fly   771 -EASSVKSAITKSISVVN-----VTAAKHLRGIHASTAVKSP-------------------SSLG 810
             ..:.|.|:...|.|..|     :.|.....|:....::.||                   |.:|
  Rat   514 HSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMG 578

  Fly   811 SCTCSDSHSPCDFCQGAPTTDLQAVGSNLKRGSTAHVETEEKLSKRRFIPSTEIE-----HV-LH 869
            |....|    |....|.|:.     |:..:..::.|.| |:|......:|....|     |. ||
  Rat   579 SLDSKD----CFGLYGEPSE-----GTTGQAQASCHPE-EQKRPNDSSMPQAASEDRAEGHSRLH 633

  Fly   870 TSLDQIGRNLTQQLNVARNLREQSQRYELPHANQRFDEIMQEHQKQSELYV---------NIKSE 925
            .|..|     |:.|.:.....:|.:...||.:       :.:..|.|...:         ::|.:
  Rat   634 ESKGQ-----TKLLQLLTTKSDQMEPSPLPSS-------LSDTNKDSTGSLPGPGSTHGTSLKEK 686

  Fly   926 YEV---QLQHKAS-------TRKSSDSDRNQE--------------QPPPPLQEDD 957
            :::   .||..:|       |.:::..:.|||              :|..|.::::
  Rat   687 HKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKEN 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	11/49 (22%)
		PAS	352..>405	CDD:238075	14/52 (27%)
		PAS_11	539..646	CDD:291273	19/106 (18%)
Ncoa2	NP_114010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		3/12 (25%)
		HLH	35..88	CDD:197674	12/52 (23%)
		PAS	119..215	CDD:279347	21/95 (22%)
		PAS	123..213	CDD:238075	20/89 (22%)
		PAS_11	268..378	CDD:291273	29/159 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..528		14/78 (18%)
		NCOA_u2	463..587	CDD:293270	24/127 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..741		38/215 (18%)
		SRC-1	640..709	CDD:285981	11/75 (15%)
		LXXLL motif 1	641..645		1/3 (33%)
		LXXLL motif 2	690..694		0/3 (0%)
		CASP8AP2-binding	691..743		9/52 (17%)
		Interaction with ARNTL. /evidence=ECO:0000250\|UniProtKB:Q61026	730..1121		2/13 (15%)
		DUF4927	731..816	CDD:292896	2/12 (17%)
		LXXLL motif 3	745..749
		LXXLL motif 4	878..882
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		Nuc_rec_co-act	1071..1116	CDD:285967
		LLXXLXXXL motif	1079..1087
		DUF1518	1281..1338	CDD:284808
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810