DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and NCOA3

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_858045.1	Gene:	NCOA3 / 8202	HGNCID:	7670	Length:	1424	Species:	Homo sapiens

Alignment Length:	793	Identity:	166/793 - (20%)
Similarity:	268/793 - (33%)	Gaps:	212/793 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 EKNRRDKLNGSIQELSTMV----PHVAESPRRVDKTAVLRFAAHALRLKHAFGNSLMQ----QRP 342
            ||.||::.:..|:||:.::    ..:.....:.||.|:|:.....:|.....|.::..    |:.
Human    34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKA 98

  Fly   343 QITDT-------------LMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHP 394
            .::.|             |:..||.|...:...|:|:.:|.::.|:|.:.|.||...|:..|.|.
Human    99 DVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHE 163

  Fly   395 ED-QNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGP-- 456
            || ::.||.  :|....|     |.|......||:|               .:|..|:....|
Human   164 EDRKDFLKN--LPKSTVN-----GVSWTNETQRQKS---------------HTFNCRMLMKTPHD 206

  Fly   457 -----RSEP---TAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQ-----LIRRTRGRDDVIPLHT 508
                 .:.|   ..||.::   ||..|.  ||.:...  ..:||     :.||
Human   207 ILEDINASPEMRQRYETMQ---CFALSQ--PRAMMEE--GEDLQSCMICVARR------------ 252

  Fly   509 ISGNDIILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCDQ---RIGIVAGYMTDEVRN 570
                  |.||           .|...:|...:.|||.:.|::::.|.   |..:..|: .|.:|.
Human   253 ------ITTG-----------ERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGF-EDIIRR 299

  Fly   571 LSPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNIIYLQSKGYLEIDKETNKVHSFV 635
            .....|..||...|......|....|.......||....:|.|:..|:|..|..:..||..|.||
Human   300 CIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFV 364

  Fly   636 CVNTLLGEEEGKR----------RVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQ 690
            ..:.|..|:.|.|          |........||...:..|...:.:|:|....|.:.:.
Human   365 STHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPST----- 424

  Fly   691 NLQKSGENGGHDDGDEDDDAQ--DGDDDEEDDDDDQDDGARSMSEF-GDPYGSHHGRSHHGSSAL 752
                :|:..|...|...:.|.  .|            .|.:|.|.: .:.||.:.....|||..|
Human   425 ----TGQMSGARYGGSSNIASLTPG------------PGMQSPSSYQNNNYGLNMSSPPHGSPGL 473

  Fly   753 ---------SSHGHGNAK------TPPLALVPPEASSVKSAITKSISVVNVTAAKHL-RGIHAST 801
                     |....|:.|      :|...:..|.|||..:. ..|.|..:::|.:.: .|:..|.
Human   474 APNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTG-NHSFSSSSLSALQAISEGVGTSL 537

  Fly   802 A-----------------VKSPSSLGSCTCSDSHSPCDF-CQGAPTTDLQAVGSNLKRGSTAHVE 848
            .                 :..||.:.:   .||.||..| |...|..     .|..:..|..|:.
Human   538 LSTLSSPGPKLDNSPNMNITQPSKVSN---QDSKSPLGFYCDQNPVE-----SSMCQSNSRDHLS 594

  Fly   849 TEEKLSKRRFIPSTE-------------IEHVLHTSLDQIGRNLTQQLNVARNLREQSQRYELPH 900
            .:|  ||...:...|             :..:|..|.|..|.:......:..:.:|.|.....|.
Human   595 DKE--SKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPS 657

  Fly   901 -------------ANQRFDEIMQEHQKQSELYVNIKSEYEVQLQHKASTRKSSDS-----DRN-- 945
                         :|.....:.::|:...:|..|..|..||......:|.|.:.|     |.|
Human   658 GVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVV 722

  Fly   946 -QEQPPPPLQEDD 957
             |||..|..:|::
Human   723 KQEQLSPKKKENN 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	11/42 (26%)
		PAS	352..>405	CDD:238075	18/53 (34%)
		PAS_11	539..646	CDD:291273	29/109 (27%)
NCOA3	NP_858045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		2/3 (67%)
		HLH	34..88	CDD:197674	13/53 (25%)
		PAS	116..173	CDD:214512	19/58 (33%)
		PAS	117..215	CDD:279347	29/119 (24%)
		PAS_11	265..375	CDD:291273	29/110 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..493		20/105 (19%)
		NCOA_u2	459..572	CDD:293270	25/116 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..520		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..674		24/146 (16%)
		SRC-1	620..704	CDD:285981	14/83 (17%)
		LXXLL motif 1	685..689		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..730		6/20 (30%)
		DUF4927	723..810	CDD:292896	5/13 (38%)
		LXXLL motif 2	738..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..798
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..945
		Interaction with CREBBP. /evidence=ECO:0000269\|PubMed:9346901	1023..1093
		Nuc_rec_co-act	1045..1092	CDD:285967
		LXXLL motif 3	1057..1061
		Acetyltransferase	1097..1304
		polyglutamine repeats	1248..1276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1273..1321
		DUF1518	1291..1348	CDD:284808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810