DRSC/TRiP Functional Genomics Resources

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Protein Alignment gce and SIM2

DIOPT Version :10

Sequence 1:NP_511160.2 Gene:gce / 32457 FlyBaseID:FBgn0261703 Length:959 Species:Drosophila melanogaster
Sequence 2:NP_005060.1 Gene:SIM2 / 6493 HGNCID:10883 Length:667 Species:Homo sapiens


Alignment Length:394 Identity:88/394 - (22%)
Similarity:155/394 - (39%) Gaps:82/394 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKHAFGNSL------ 337
            :|....|.|.||:|.||...||:.::|..:....::||.:::|.....|:::..|...|      
Human     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQ 66

  Fly   338 -MQQRP------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHPE 395
             .:..|      ::...|:..||.|...:...|.|:.||.:...|||..|.:|.|.||.:..||.
Human    67 PSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPS 131

  Fly   396 DQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVR----LARAGP 456
            |.:         |:..:..||       :|......:|..|:       |||.:|    ||:...
Human   132 DHD---------EMTAVLTAH-------QPLHHHLLQEYEIE-------RSFFLRMKCVLAKRNA 173

  Fly   457 RSEPTAYEVVKIDGCFRRSDEAPRGVRS-----NHFSSNLQLIRRTRGRDDVIPLHTISGNDIIL 516
            ....:.|:|:...|..:        :|.     :.:.|..|::.                    |
Human   174 GLTCSGYKVIHCSGYLK--------IRQYMLDMSLYDSCYQIVG--------------------L 210

  Fly   517 TGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDD 581
            ....:.:.|..|....:.:|...:  |..:|.::|..|.|:..|.||...::...:.:..:|..|
Human   211 VAVGQSLPPSAITEIKLYSNMFMF--RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCD 273

  Fly   582 VRWVIVALRQMYDCNSSYGEST---YRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNTLLGE 643
            |    ..||..:......|:.|   |||.::.|..:::||...:..:..:::.|..|.||.:|.|
Human   274 V----FHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE 334

  Fly   644 EEGK 647
            .|.|
Human   335 IEYK 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gceNP_511160.2 bHLH_PAS 279..333 CDD:381397 15/53 (28%)
PAS 352..>405 CDD:238075 18/52 (35%)
PAS_11 537..646 CDD:464214 27/111 (24%)
SIM2NP_005060.1 bHLH_SF 1..74 CDD:469605 18/71 (25%)
PAS 79..140 CDD:214512 20/69 (29%)
PAS_11 91..194 CDD:464214 32/133 (24%)
PAS_3 243..329 CDD:430001 21/89 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..389
SIM_C 358..660 CDD:461963
Nuclear localization signal. /evidence=ECO:0000269|PubMed:14697214 367..386
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..428
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..520
Blue background indicates that the domain is not in the aligned region.

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