DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and Clock

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001376183.1	Gene:	Clock / 60447	RGDID:	620271	Length:	864	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	156/734 - (21%)
Similarity:	265/734 - (36%)	Gaps:	230/734 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKH------AFGNSL 337
            |.:||::||.|||:.|..|:||.:|:|..|   |::||:.||:.:...|| ||      :..:.:
  Rat    36 RVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLR-KHKEITAQSDASEI 96

  Fly   338 MQQ-RP------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHPE 395
            .|. :|      :.|..:::.||.|||.:...|.::.:|.::...|.|..|||..|||.... ||
  Rat    97 RQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSVVYVSETVTSLLEHLPSDLVDQSIFNFI-PE 160

  Fly   396 DQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGPRSEP 460
            .::....:::.|.|.       :||:......:||.:.:.....||          ....|: ||
  Rat   161 GEHSEVYKILSTHLL-------ESDSLTPEDLKSKNQLEFCCHMLR----------GTIDPK-EP 207

  Fly   461 TAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRP 525
            :.||.|:..|.|:..:....... |.|...:|...|....|.|..:.|:           |:..|
  Rat   208 STYEYVRFIGNFKSLNSVSTSTH-NGFEGTIQRTHRPSYEDRVCFVATV-----------RLATP 260

  Fly   526 PKIASR-LIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVAL 589
            ..|... .::....|:.:||.::.:.:..|.|...:.||:..||...|.:.:.|.||:.    :|
  Rat   261 QFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLE----SL 321

  Fly   590 RQMYDCNSSYGEST---YRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNTLL--GEEEGKRR 649
            .:.::....||:..   ||..|:....|:||:..|:...:..::....||.:|::  .|...:||
  Rat   322 AKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERR 386

  Fly   650 VQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQDGD 714
             :|:                                                  |.|:...:...
  Rat   387 -REL--------------------------------------------------GIEESLPETAA 400

  Fly   715 DDEEDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSHGHGNAKTPPLALVPPEASSVKSAI 779
            |..:|...|......|:.|                 ||....|...         |.|||..|
  Rat   401 DKSQDSGSDNRINTVSLKE-----------------ALERFDHSPT---------PSASSRSS-- 437

  Fly   780 TKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQGAPTTDLQAVGSNLKRGST 844
            .||                :.|||..|||..:...:|:.:|                      ..
  Rat   438 RKS----------------SHTAVSDPSSTPTKIPTDTSTP----------------------PR 464

  Fly   845 AHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQ----------------------QLNVAR 887
            .|:...||:::||...|::     ..:...:|.:|||                      ||...:
  Rat   465 PHLPAHEKMTQRRSSFSSQ-----SINSQSVGSSLTQPAMSQAANLPIPQGMSQFQLSAQLGAMQ 524

  Fly   888 NLREQ-SQRYELPHANQRFDEIMQEHQKQSELYVNIKSEYEVQLQHK----------------AS 935
            :|::| .||..:..||        .|::|.||.   |.:.::|:.|.                .|
  Rat   525 HLKDQLEQRTRMIEAN--------IHRQQEELR---KIQEQLQMVHGQGLQMFLQQSNPGLNFGS 578

  Fly   936 TRKSSDSDRNQEQPPPPLQ 954
            .:.||.:...|:..|..:|
  Rat   579 VQLSSGNSNIQQLTPINMQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	20/45 (44%)
		PAS	352..>405	CDD:238075	17/52 (33%)
		PAS_11	539..646	CDD:291273	27/111 (24%)
Clock	NP_001376183.1	bHLH-PAS_CLOCK	29..89	CDD:381577	24/56 (43%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O08785	32..47		5/10 (50%)
		PAS	109..202	CDD:395786	26/110 (24%)
		PAS_11	274..377	CDD:405306	26/106 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..497		35/229 (15%)
		Interaction with SIRT1. /evidence=ECO:0000250\|UniProtKB:O08785	450..570		28/157 (18%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840