DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and arntl2

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_571653.2	Gene:	arntl2 / 58099	ZFINID:	ZDB-GENE-000509-2	Length:	631	Species:	Danio rerio

Alignment Length:	517	Identity:	127/517 - (24%)
Similarity:	206/517 - (39%)	Gaps:	114/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAA-HALRLKHAFGN-SLMQQR 341
            ||..::.||.||||:|..|.||:.|:|......|::||..|||.|. |...||.|..: :....:
Zfish    91 REPHSQIEKRRRDKMNNLIDELAAMIPTCNPMSRKLDKLTVLRMAVQHLKSLKGATSSFAEANYK 155

  Fly   342 P------QITDTLMDMLDSFFLTLTC-HGHILLISASIEQHLGHCQSDLYGQSIMQITHPEDQNM 399
            |      ::...::...|.|...:.| .|.|:.:|.|:.:.|.:.:::|.|||:....||:|...
Zfish   156 PAFLPDDELKHLVLRAADGFLFVVGCDRGKIVFVSESVSKTLNYSRTELIGQSLFDYVHPKDIGK 220

  Fly   400 LKQQLIPTEL---ENLFDAHGDSDAEGE-PRQRSKAEEDAIDRKLREDRRSFRVRL--------- 451
            :|:||..:||   |.|.||......:.| |...::....|        ||||..|:
Zfish   221 VKEQLSASELYPRERLIDAKTGLQVQAELPVGSARLCSGA--------RRSFFCRMKYNKITVKE 277

  Fly   452 -----ARAGPRSEPTAYEVVKIDGCFR--------RSDEAPRGVRSNHFSSNLQLIRRTRGRDDV 503
                 |.|..:.|...|..|...|..|        ...||.....|:|||..:.:     ||  |
Zfish   278 EKDFQAGASKKKESQRYCTVHCTGYMRTWPTRQLATEGEAEADKESSHFSCLVAM-----GR--V 335

  Fly   504 IPLHTISGNDIILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEV 568
            .| ||:                |: |:..|.....|:.||:.:||:....|||...:.||:..|:
Zfish   336 HP-HTL----------------PQ-ANGEIKVKPTEFVTRYAMDGKFTFVDQRATTILGYLPQEL 382

  Fly   569 RNLSPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNIIYLQSKGYLEIDKETNKVHS 633
            ...|.:.:.|.||:..:....|::.........:.|:..|::|:.:.|||:.:..|:..|.:|..
Zfish   383 LGTSCYEYFHLDDLPHLAERHRKVLRSKEKIETNCYKFKTKSGSFVNLQSQWFSFINPWTKEVEY 447

  Fly   634 FVCVNTLL------------GEEEGKRRVQEMKKK------------------FSVIINTQIPQS 668
            .|..||::            .|:....:..|...|                  ::..|.|||...
Zfish   448 IVSTNTVVSGKSNPGGSGDKAEQPSSSKASEDDAKKSQQVPIIPGISSASGMIYAGCIGTQIANE 512

  Fly   669 TIDV------PASEHPA----LLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQDGDDDEEDD 720
            .:|.      |:|.:.:    |.:|:.|.|.|      .:....:|:..|....|....|::
Zfish   513 IMDFNRMNSSPSSGNTSPFSLLQDKSPLALAQ------ASSNVPNGEATDVEMPGKSSSEEE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	21/46 (46%)
		PAS	352..>405	CDD:238075	17/53 (32%)
		PAS_11	539..646	CDD:291273	29/118 (25%)
arntl2	NP_571653.2	HLH	91..143	CDD:306515	22/51 (43%)
		PAS	172..266	CDD:238075	31/101 (31%)
		PAS_3	353..456	CDD:330807	28/102 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940