DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and ncoa3

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_021335474.1	Gene:	ncoa3 / 564519	ZFINID:	ZDB-GENE-051107-8	Length:	1504	Species:	Danio rerio

Alignment Length:	783	Identity:	158/783 - (20%)
Similarity:	269/783 - (34%)	Gaps:	244/783 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 EKNRRDKLNGSIQELSTMV----PHVAESPRRVDKTAVLRFAAHALRL-----KHAFGNSLMQQ- 340
            :|.||::.:..|:||:.::    ..:.....:.||.|:|:.....:|.     |.:.|:..:|:
Zfish    31 DKRRREQESKYIEELAELISANLSDIDSFNVKPDKCAILKETVRQIRQIKEQGKSSCGDDDVQKA 95

  Fly   341 -----------RPQITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHP 394
                       :..:...|:..||.|...::..|.|:.:|.::.|:|.:.|.:|...||..|.|.
Zfish    96 DVSSTGQGVIDKDHLGPLLLQALDGFLFVVSREGSIVFVSDNVTQYLQYKQEELINTSIYNILHE 160

  Fly   395 EDQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFR----VRLARAG 455
            ||:..|.:.|..:...|.....|||.     ||:|               .:|.    |:....|
Zfish   161 EDREELHKNLPKSNGPNSVSWGGDSS-----RQKS---------------HTFNCRMLVKFGHGG 205

  Fly   456 PRSEPTA----YEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIIL 516
            |..|..|    ||.::   ||..:.  |:.:..                         .|.|  |
Zfish   206 PGGEEGAGGPRYETMQ---CFALTQ--PKAMME-------------------------EGED--L 238

  Fly   517 TGCARIIRPPKIASRLIDA--NTLEYKTRHLIDGRIIDCDQ--------RIGIVAGYMTDEVRNL 571
            ..|...:      :|.:.|  .|..:.|||.:.|::|:.:|        |.|     ..|.||..
Zfish   239 QSCMICV------ARRVTAVERTERFSTRHELSGKLIEIEQQSLLHTTMRPG-----WEDLVRRC 292

  Fly   572 SPFTFMHNDDVR-WVIVALRQMYDCNSSYGES---TYRLFTRNGNIIYLQSKGYLEIDKETNKVH 632
            ... |:|..:.: |   :.::.|.....:|.:   .||....:|..:..|::..|..:..|:..|
Zfish   293 MQM-FLHRSEGQPW---SYKRHYHEAYVHGRAETPPYRFSLSDGTPVTAQTRSELCRNPVTSDPH 353

  Fly   633 SFVCVNTLLGEEEGKRRVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGE 697
            :|:..:.|..|:.|.|..|....: ||:.|.. |.:.:.:..:....:.|:..:         |.
Zfish   354 TFLSTHLLQREQNGYRPNQGGVMR-SVMGNAN-PNAQMGMGNTRGYGMNEQGHM---------GP 407

  Fly   698 NGG--HDDGDEDDDA---------------------------QDGDDDEEDDDDDQDDGARSMSE 733
            .||  :..|:..:..                           |.|..::.    :|.:...||::
Zfish   408 RGGAMYGPGNRMNQMNPMHQMNQMNQMNSMNQMNMNQMNCMNQMGSMNQM----NQMNQMNSMNQ 468

  Fly   734 FGDPYGSHH--GRSHHGSSALSSHGHGNAKTPP-------------LALVPPEASSVK------- 776
            .|.|..:.|  |:.|.|.      |:|...|.|             |...|....|.|
Zfish   469 MGHPGMNQHQQGQFHGGG------GYGMVMTSPSQGSPGMNPGQQNLMGSPRIRGSPKMGASPFS 527

  Fly   777 ---------------SAITKSISVVNVTAAKHLRGIHA-STAVKS--PSSLGSCTCSDSHSP--- 820
                           |:.:...||.|..::..|..:.| |..|.|  ||:|.|.......||
Zfish   528 PGGMHSPMGPVGMGGSSGSSGPSVGNTFSSSSLNALQAISEGVGSSLPSALNSPAHKSDSSPNIN 592

  Fly   821 -CDFCQGAPTTDLQAVGSNLKRGSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQQLN 884
             ....|..|..:.:.:.|:.|..|:||                      .|.|||      ||.:
Zfish   593 STQSSQQGPIGNNKPITSDSKSPSSAH----------------------STGLDQ------QQAS 629

  Fly   885 VARNL-REQSQRYELPHA----NQRFDEIMQEHQKQSELYVNIKSEYEV------QLQHKASTRK 938
            ...|. :..||..:...|    |:|..: .:.|:|..:|..:...|..:      .:..:|||..
Zfish   630 STENTDKPDSQSNKDGSAGGEVNRRVPD-GKGHKKLLQLLTSPTEEIGIGTATSGPVPGRASTPM 693

  Fly   939 SSD 941
            .||
Zfish   694 GSD 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	10/42 (24%)
		PAS	352..>405	CDD:238075	17/52 (33%)
		PAS_11	539..646	CDD:291273	26/118 (22%)
ncoa3	XP_021335474.1	HLH	32..85	CDD:197674	11/52 (21%)
		PAS	113..170	CDD:214512	18/56 (32%)
		PAS_3	256..367	CDD:330807	26/119 (22%)
		NCOA_u2	490..617	CDD:318802	25/126 (20%)
		SRC-1	663..773	CDD:312390	8/34 (24%)
		DUF4927	795..880	CDD:318508
		Nuc_rec_co-act	1094..1141	CDD:312376
		DUF1518	1348..1406	CDD:311422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900