DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and ncoa1

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_021324335.1	Gene:	ncoa1 / 563288	ZFINID:	ZDB-GENE-041001-175	Length:	1349	Species:	Danio rerio

Alignment Length:	786	Identity:	146/786 - (18%)
Similarity:	233/786 - (29%)	Gaps:	309/786 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 MFQLSNSGR--------EARNR-----------AEKNRR-----------DKLNGSIQELSTM-- 303
            |.::|.:|.        |:|.|           .||.||           :.|:.::.:::::
Zfish     1 MLKMSAAGENALDPNILESRKRKGSPCDTSGPSVEKRRRELECRYIDELAELLSANMSDIASLNV 65

  Fly   304 -----------VPHVAESPRRVDKTAVL------------RFAAHALRLKHAFGNSLMQQRPQIT 345
                       |..:.:..||..:.|.|            ..::|.:..|.|.|
Zfish    66 KPDKCHILKSTVDQIQQIKRREQENAALMSPNDEVQQSDISSSSHGMVEKEALG----------- 119

  Fly   346 DTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHPEDQNMLKQQLIPTELE 410
            ..|::.||.||..:...|.|:.:|.::..:||:.|.:|...|:..|.|..|.|...:.|:|..|.
Zfish   120 PLLLEALDGFFFVVNREGRIVFVSENVTGYLGYTQEELMTSSVYSILHVGDHNEFVRILLPKSLV 184

  Fly   411 NLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGP-------RSEPTAYEVVKI 468
            |           |.|..:.:.         |.:..:|..||.:..|       :.....||:::
Zfish   185 N-----------GVPWSQEQG---------RRNSHTFNCRLLKRPPDEVDSENQEARQQYELMQ- 228

  Fly   469 DGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRPPKIASRLI 533
              ||..|.  |:.::..  ..:||                   :.:|...| :|.|||:     |
Zfish   229 --CFTVSQ--PKALQEE--GEDLQ-------------------SCLICIAC-QIPRPPQ-----I 262

  Fly   534 DANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVALRQMYDCNSS 598
            ..:|..:.|:....|:||..:.......|....|            |.||..|.|..|......|
Zfish   263 PVSTESFITKQDPTGKIISIETSALRATGRPGWE------------DLVRKCIYAFFQPQGNEPS 315

  Fly   599 YGES--------------TYRLFTRNGNIIYLQSK----------------GYLEIDKETNKVHS 633
            :.:.              .|.....:|..:..|::                |:..||:|.|...|
Zfish   316 HAKKLLHEVMTHGMAISPLYHFTLSDGTSLSAQTRCKFCCPQNPDVQPFIMGFHTIDREHNTASS 380

  Fly   634 FVCVNTLLGEEEGKRRVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGEN 698
                             ||         ||....|:...|.|..|||...:.|    ::..:..|
Zfish   381 -----------------QE---------NTTPSLSSPAAPPSRSPALQPSSDL----SIHLNNTN 415

  Fly   699 G-------------GHDDGDEDDDAQDGDDDEEDDDDDQDDGARSMSEFGDPYGS-----HHGRS 745
            |             |:........:|.               ..|.|..|.|..:     ...|.
Zfish   416 GTCATPGPLTPTPPGYLTPSRVGPSQQ---------------VSSPSPLGSPLTATPTSFMSPRP 465

  Fly   746 HHGSSALSSH----GH--------------------------------------------GNAKT 762
            ..||..|:|.    ||                                            ..|:.
Zfish   466 PRGSPGLASSPRVPGHPFSPSTPSIHSPAGGLTRQQSGGDGVGFSLPSPLPPRQTPTPSSSPARQ 530

  Fly   763 PPLALVPPEASSVKSAITKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQGA 827
            ||..  |||||:.:   .||..|.|...::.|.|..|......|....:..|..|||       :
Zfish   531 PPAK--PPEASNDE---PKSNQVGNPKLSQLLDGASAPEQDSQPRPSPTSQCPASHS-------S 583

  Fly   828 PTTDLQAVGSNLKRGSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQQLNVARNLREQ 892
            .|...:.:...|:..|.|....|..:.|.   |.|.....|                :||.|.::
Zfish   584 LTERHKILHRLLQDNSPADAGKEPDIKKE---PPTSPNSAL----------------IARGLGKE 629

  Fly   893 SQRYEL 898
            .|.::|
Zfish   630 PQDHQL 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	13/100 (13%)
		PAS	352..>405	CDD:238075	16/52 (31%)
		PAS_11	539..646	CDD:291273	22/136 (16%)
ncoa1	XP_021324335.1	HLH	35..89	CDD:197674	8/53 (15%)
		PAS	121..178	CDD:214512	17/56 (30%)
		PAS_11	267..376	CDD:317051	20/120 (17%)
		Atrophin-1	<384..670	CDD:331285	57/302 (19%)
		Nuc_rec_co-act	869..913	CDD:312376
		DUF1518	1150..1206	CDD:311422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900