DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and ARNT

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	768	Identity:	155/768 - (20%)
Similarity:	268/768 - (34%)	Gaps:	160/768 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKHAFGNSLM--QQR 341
            ||..:..|:.||:|:...|.|||.|||..:...|:.||..:||.|...::.....||:..  ..:
Human    91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYK 155

  Fly   342 PQ-ITD-----TLMDMLDSFFLTLTCH-GHILLISASIEQHLGHCQSDLYGQSIMQITHPEDQNM 399
            |. :||     .:::..|.|...::|. |.::.:|.|:...|...||:.:|.::....||:|.:.
Human   156 PSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDK 220

  Fly   400 LKQQLIPTE---LENLFDAH-GDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGPRS-E 459
            |::||..:|   ...:.|.. |....||   |:|..      |.....||||..|: |.|..| :
Human   221 LREQLSTSENALTGRILDLKTGTVKKEG---QQSSM------RMCMGSRRSFICRM-RCGSSSVD 275

  Fly   460 PTAYEVVKI------DGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGND----- 513
            |.:...:..      :|.....|..|      ||     ::....|.....|...:|..|
Human   276 PVSVNRLSFVRNRCRNGLGSVKDGEP------HF-----VVVHCTGYIKAWPPAGVSLPDDDPEA 329

  Fly   514 -------IILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNL 571
                   ::..|..::...|............|:.:||.|:|.....|.|.....||...|:...
Human   330 GQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 394

  Fly   572 SPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVC 636
            :...|.|.:|.:.:..:.:|:...........:|..::|...:::::..:...:..::::...:|
Human   395 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIIC 459

  Fly   637 VNTLLGEEEGKRRVQEMKKKFSVII----------------------NTQIPQSTID-VPASEHP 678
            .||.:     |...||.:...|..|                      ..|..|:.:| ||..:..
Human   460 TNTNV-----KNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGL 519

  Fly   679 ALLEKAVLRLIQNLQKSGENGGHDDGDEDDD---AQDGD----DDEEDDDDDQDDGARSMSEFGD 736
            |....:  :::|.:..:|..  |....|..|   |||.|    :...:.:.||..|..|.:....
Human   520 ASYNHS--QVVQPVTTTGPE--HSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPAT 580

  Fly   737 PYGSHHGRSHHGSSALSSHGHGNAKTPPLALVPPEASSVKSAITKSISVVNVTAAKHLRGIHAST 801
            ......|.:...:...:.:...:...||:.:|.|.||:  ..:...||       :|......:|
Human   581 QQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASA--GQMLAQIS-------RHSNPTQGAT 636

  Fly   802 AVKSPSS-----------------------LGSCTCSDSHSPCDFCQGAPTTD--LQAVGSNLKR 841
            ...:|::                       :||.....|.|.... .||||..  ..|..|...|
Human   637 PTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSL-PGAPTASPGAAAYPSLTNR 700

  Fly   842 GSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQQLNVARNLREQSQRYELPHANQRFD 906
            ||             .|.|.|      ..:..|......:.:.|....:.|...:....:.|...
Human   701 GS-------------NFAPET------GQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQ 746

  Fly   907 EIMQEHQKQSELYVNIKSEYEVQLQHKASTRKSSDSDRNQEQPP----PPLQE 955
            :...:...|.|::..:.|....|          |:|..|:|.|.    ||..|
Human   747 QPPAQQPGQPEVFQEMLSMLGDQ----------SNSYNNEEFPDLTMFPPFSE 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	19/45 (42%)
		PAS	352..>405	CDD:238075	15/53 (28%)
		PAS_11	539..646	CDD:291273	19/106 (18%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		2/5 (40%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		14/36 (39%)
		HLH	91..143	CDD:278439	19/51 (37%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		43/160 (27%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		16/55 (29%)
		PAS	163..269	CDD:279347	29/115 (25%)
		PAS	166..230	CDD:214512	16/63 (25%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		0/3 (0%)
		PAS_11	362..462	CDD:291273	17/99 (17%)
		PAS	362..458	CDD:238075	16/95 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		5/26 (19%)
		Med3	<523..>734	CDD:288447	44/243 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789		29/146 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740