DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and cyc

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	102/427 - (23%)
Similarity:	170/427 - (39%)	Gaps:	112/427 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALR------LKHAFGNSL 337
            ::..:..||.||||:|..|.|||:|:|......|::||..|||.|...||      ..|.|..|
  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGS- 95

  Fly   338 MQQRPQ-ITDTLMDML-----DSFFLTLTC-HGHILLISASIEQHLGHCQSDLYGQSIMQITHPE 395
             ..||. ::|..:.|:     :.|...:.| .|.||.:|.|:...|...|:||.|||...:.||:
  Fly    96 -DYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPK 159

  Fly   396 DQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRK----LRED------------R 444
            |...:|:||              |..|..||:|      .||.|    ::.|            |
  Fly   160 DIGKVKEQL--------------SSLEQCPRER------LIDAKTMLPVKTDVPQSLCRLCPGAR 204

  Fly   445 RSF--RVRLARAG-------------------PRSEPTA---YEVVKIDGCFRR----SDEAPRG 481
            |||  |::|..|.                   .:|..|.   |.|::..|..:.    .|| .:.
  Fly   205 RSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDE-DQD 268

  Fly   482 VRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRPPKIASRLIDANT--------L 538
            ..|:..::||.                      .|....||  ||.:.:..:.|:.        :
  Fly   269 ADSDEQTTNLS----------------------CLVAIGRI--PPNVRNSTVPASLDNHPNIRHV 309

  Fly   539 EYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVALRQMYDCNSSYGEST 603
            .:.:||..:|:.:..|||..:|.|::..|:...|.:.:.||:|:..::.:.:.:...........
  Fly   310 LFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQV 374

  Fly   604 YRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNTL 640
            ||...::.:.|.|||:.....:..|:::...:..|::
  Fly   375 YRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	20/45 (44%)
		PAS	352..>405	CDD:238075	19/58 (33%)
		PAS_11	539..646	CDD:291273	21/102 (21%)
cyc	NP_524168.2	HLH	31..84	CDD:278439	22/51 (43%)
		PAS	111..212	CDD:279347	34/120 (28%)
		PAS	111..173	CDD:214512	21/75 (28%)
		PAS_11	311..411	CDD:291273	21/99 (21%)
		PAS	311..406	CDD:238075	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910