DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and clockb

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_840080.2	Gene:	clockb / 352927	ZFINID:	ZDB-GENE-030408-2	Length:	820	Species:	Danio rerio

Alignment Length:	739	Identity:	162/739 - (21%)
Similarity:	288/739 - (38%)	Gaps:	175/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 MMEMFQLSNSGREARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALR---- 328
            :||..:...:.|.:||::||.|||:.|..|:||.||:|   .:.|::||:.:|:.:...||
Zfish    15 LMEEDEKDKAKRVSRNKSEKKRRDQFNVLIKELGTMLP---GNTRKMDKSTILQKSIDYLRKNKE 76

  Fly   329 -LKHAFGNSLMQQ-RP------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYG 385
             ...:..:.:.|. :|      :.:..:::.||.|||.:...|:|:.||.|:...|.|..|||..
Zfish    77 NAAQSESSDIKQDWKPPFLSNEEFSQLMLEALDGFFLVMLTDGYIIYISESVTSLLEHLPSDLMD 141

  Fly   386 QSIMQ----ITHPEDQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRS 446
            |:::.    :.|.|....|..|   .::|||     :||     ..:||.:.:.....||
Zfish   142 QNLLNFLPVVDHGEVYKALSSQ---PDIENL-----NSD-----YLKSKNQMEFCCHMLR----- 188

  Fly   447 FRVRLARAGPRSEPTAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTIS- 510
                 ....|: :|..||.||..|               :|.|.:.:.::||...:.|..|::.
Zfish   189 -----GSVDPK-KPPVYEYVKFIG---------------NFKSLVNMPQKTRNGLEGILQHSLQP 232

  Fly   511 --GNDIILTGCARIIRPPKIASR-LIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLS 572
              .:.:......|:.:|..|... :::....|:.:||.::.:.:..|.|...:.|||..||...|
Zfish   233 AFDDQLCFIATVRLAKPQFIKEMCMVEEPNEEFTSRHSLEWKFLLLDHRAPPIIGYMPFEVLGTS 297

  Fly   573 PFTFMHNDDVRWVIVALRQMYDCNSSYGEST---YRLFTRNGNIIYLQSKGYLEIDKETNKVHSF 634
            .:.:.|.||:.    :|.:.::....:|:..   ||..|:....|:||:..|:...:..::....
Zfish   298 GYDYYHVDDLH----SLAKCHEHLMQFGKGKSCYYRFLTKGQQWIWLQTNYYITYHQWNSRPEFI 358

  Fly   635 VCVNTLL--GEEEGKRRVQEMKKKFSVIINTQIPQSTID-VPASEHPALLEKAVLRLIQNLQKSG 696
            ||.:|::  .|...:|| :||.      |....|:.|.| :..||  ..|..::.::::..
Zfish   359 VCTHTVVSYAEVRAERR-REMG------IEESPPELTADKISGSE--TQLNNSLKKVLERF---- 410

  Fly   697 ENGGHDDGDEDDDAQDGDDDEEDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSHGHGNAK 761
                                       .|..:.|.|.......||...|.:..::..|..|.:..
Zfish   411 ---------------------------SDSRSPSTSSRSSHKSSHTAISDNTCTSTPSKLHMDVS 448

  Fly   762 TPPLALVPPEASSVKSAI-TKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQ 825
            :.|........|..:|:: |:|:|..|            :|...||..:...|......|....|
Zfish   449 SSPRPATVDMISQRRSSVSTQSMSSQN------------TTQTDSPVQISQQTQHQQQQPQQPQQ 501

  Fly   826 GAPTTDLQAVGSNLKRGSTAHVETEEKLSKR-RFIPSTEIEHVLHTSLDQIGRNLTQQLNVARNL 889
            ..|.....|     :..:..|:  :|:|.:| |.|.:                |:.:|....|.:
Zfish   502 VQPNALFSA-----QLNAMQHL--KEQLEQRTRMIEA----------------NIQKQQEELRQI 543

  Fly   890 REQSQRYELPHANQRFDEIMQEHQKQSELYV----------NI------KSEYEVQLQHKASTRK 938
            .||.||.:.|..      |:|:..:.....|          ||      .|...:|.|:..||..
Zfish   544 HEQLQRVQGPQM------ILQQPAQGGGPSVLLPQVGGAQNNILGIGTQASVVAIQGQNVTSTAH 602

  Fly   939 SSDSDRN----QEQPPPPLQEDDQ 958
            |..:.:.    |:|.|..||::.|
Zfish   603 SGSAPQQQTLPQQQTPRSLQQNLQ 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	19/45 (42%)
		PAS	352..>405	CDD:238075	20/56 (36%)
		PAS_11	539..646	CDD:291273	27/111 (24%)
clockb	NP_840080.2	HLH	22..76	CDD:238036	21/56 (38%)
		PAS	99..160	CDD:214512	18/60 (30%)
		PAS_11	263..366	CDD:291273	26/106 (25%)
		PAS	264..362	CDD:238075	25/101 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740