DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and Ncoa2

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_017174718.1	Gene:	Ncoa2 / 17978	MGIID:	1276533	Length:	1517	Species:	Mus musculus

Alignment Length:	842	Identity:	158/842 - (18%)
Similarity:	267/842 - (31%)	Gaps:	289/842 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 GREARNRAEKNRRDKLNGSIQELSTMV----PHVAESPRRVDKTAVLRFAAHALRL-----KHAF 333
            |...:...||..|::.|..|:||:.::    ..:.....:.||.|:|:.....:|.     |.|.
Mouse    27 GPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91

  Fly   334 GNSLMQQRPQITDT-------------LMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYG 385
            .|....|:..::.|             :::.||.||..:...|.::.:|.::.|:|.:.|.:|..
Mouse    92 ANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMN 156

  Fly   386 QSIMQITHPEDQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVR 450
            :|:..|.|..|.....:.|:|..:.|     |.| ..|||.:||.              .:|..|
Mouse   157 KSVYSILHVGDHTEFVKNLLPKSMVN-----GGS-WSGEPPRRSS--------------HTFNCR 201

  Fly   451 -LARAGPRSEPTA---------YEVVKIDGCFRRSDEAPRGVRSNHFSSNLQ-----LIRRTRGR 500
             |.:..|.||...         ||.::   ||..|.  |:.::..  ..:||     :.||
Mouse   202 MLVKPLPDSEEEGHDSQEAHQKYEAMQ---CFAVSQ--PKSIKEE--GEDLQSCLICVARR---- 255

  Fly   501 DDVIPLHTISGNDIILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCD---QRIGIVAG 562
               :|:..               ||...:|.       .:.||..:.|:|...|   .|..:..|
Mouse   256 ---VPMKE---------------RPTLPSSE-------SFTTRQDLQGKITSLDTSTMRAAMKPG 295

  Fly   563 YMTDEVR-------------NLSPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNII 614
            : .|.||             :|| :...|:.:|....:|..|:           ||....:|.::
Mouse   296 W-EDLVRRCIQKFHTQHEGESLS-YAKRHHHEVLRQGLAFSQI-----------YRFSLSDGTLV 347

  Fly   615 YLQSKGYLEIDKETNK------VHSF-----VCVNT--LLGEEEGKRRVQEMKKKFSVIINTQIP 666
            ..|:|..|...:.||:      :|..     |||..  |.|:..||                  |
Mouse   348 AAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGK------------------P 394

  Fly   667 QSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQDGDDDEEDDDDDQDDGARSM 731
            .:.|...:..|.||.                     .|:...|...|.:.....:..::.....|
Mouse   395 LNPISSSSPAHQALC---------------------SGNPGQDMTLGSNINFPMNGPKEQMGMPM 438

  Fly   732 SEFGDPYGSHH----------GRSH-----------------HGSSALSSH---GHGNAKTPPLA 766
            ..||...|.:|          |.::                 ..||.||..   ..|.|.:|
Mouse   439 GRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSP--- 500

  Fly   767 LVPPEASSVKSAITKSISVVNVTAAKHL---------------RGIHASTAVKSP---------- 806
            .:||...|...::...:.|.:.|...|.               .|:...:::.||
Mouse   501 RIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNS 565

  Fly   807 ---------SSLGSCTCSDSHSPCDFCQGAPTTDLQAVGSNLKRGSTAHVETEEKLSKRRFIPS- 861
                     |.:||....|    |....|.|:.     |:..:..::.|.| |:|......:|.
Mouse   566 PVNMNPPPLSKMGSLDSKD----CFGLYGEPSE-----GTTGQAEASCHPE-EQKGPNDSSMPQA 620

  Fly   862 -----TEIEHVLHTSLDQIGRNLTQQLNVARNLREQSQRYELPHA----------------NQRF 905
                 .|....||.|..|     |:.|.:.....:|.:...||.:                :...
Mouse   621 ASGDRAEGHSRLHDSKGQ-----TKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHG 680

  Fly   906 DEIMQEHQKQSELYVNIKSEYEVQ-----------LQHKASTRKSSDSDRNQEQPPPPLQED 956
            ..:.::|:....|..:..|..::.           .|..:||...|:....||...|..:|:
Mouse   681 TSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKEN 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	11/49 (22%)
		PAS	352..>405	CDD:238075	14/52 (27%)
		PAS_11	539..646	CDD:291273	30/135 (22%)
Ncoa2	XP_017174718.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	13/62 (21%)
		PAS	118..175	CDD:214512	14/56 (25%)
		PAS_11	268..378	CDD:405306	25/129 (19%)
		NCOA_u2	463..587	CDD:406952	21/130 (16%)
		SRC-1	636..709	CDD:400955	9/77 (12%)
		DUF4927	731..816	CDD:406644	4/12 (33%)
		Nuc_rec_co-act	1076..1120	CDD:400942
		Med15	<1130..>1408	CDD:312941
		DUF1518	1284..1341	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810