DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and Clock

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001276755.1	Gene:	Clock / 12753	MGIID:	99698	Length:	855	Species:	Mus musculus

Alignment Length:	737	Identity:	159/737 - (21%)
Similarity:	262/737 - (35%)	Gaps:	236/737 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKH------AFGNSL 337
            |.:||::||.|||:.|..|:||.:|:|..|   |::||:.||:.:...|| ||      :..:.:
Mouse    36 RVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLR-KHKETTAQSDASEI 96

  Fly   338 MQQ-RP------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQITHPE 395
            .|. :|      :.|..:::.||.|||.:...|.|:.:|.|:...|.|..|||..|||.... ||
Mouse    97 RQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFI-PE 160

  Fly   396 DQNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGPRSEP 460
            .::....:::.|.|.       :||:......:||.:.:.....||          ....|: ||
Mouse   161 GEHSEVYKILSTHLL-------ESDSLTPEYLKSKNQLEFCCHMLR----------GTIDPK-EP 207

  Fly   461 TAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPLHTISGNDIILTGCARIIRP 525
            :.||.|:..|.|:.......... |.|...:|...|....|.|..:.|:           |:..|
Mouse   208 STYEYVRFIGNFKSLTSVSTSTH-NGFEGTIQRTHRPSYEDRVCFVATV-----------RLATP 260

  Fly   526 PKIASR-LIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVAL 589
            ..|... .::....|:.:||.::.:.:..|.|...:.||:..||...|.:.:.|.||       |
Mouse   261 QFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDD-------L 318

  Fly   590 RQMYDCNS---SYGEST---YRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNTLL--GEEEG 646
            ..:..|:.   .||:..   ||..|:....|:||:..|:...:..::....||.:|::  .|...
Mouse   319 ENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRA 383

  Fly   647 KRRVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGHDDGDEDDDAQ 711
            :|| :|:                                                  |.|:...:
Mouse   384 ERR-REL--------------------------------------------------GIEESLPE 397

  Fly   712 DGDDDEEDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSHGHGNAKTPPLALVPPEASSVK 776
            ...|..:|...|......|:.|                 ||....|...         |.|||..
Mouse   398 TAADKSQDSGSDNRINTVSLKE-----------------ALERFDHSPT---------PSASSRS 436

  Fly   777 SAITKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQGAPTTDLQAVGSNLKR 841
            |  .||                :.|||..|||..:...:|:.:|
Mouse   437 S--RKS----------------SHTAVSDPSSTPTKIPTDTSTP--------------------- 462

  Fly   842 GSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQ----------------------QLN 884
             ...|:...||:::||...|::     ..:...:|.:|||                      ||.
Mouse   463 -PRQHLPAHEKMTQRRSSFSSQ-----SINSQSVGPSLTQPAMSQAANLPIPQGMSQFQFSAQLG 521

  Fly   885 VARNLREQ-SQRYELPHANQRFDEIMQEHQKQSELYVNIKSEYEVQLQHK--------------- 933
            ..::|::| .||..:..||        .|::|.||.   |.:.::|:.|.
Mouse   522 AMQHLKDQLEQRTRMIEAN--------IHRQQEELR---KIQEQLQMVHGQGLQMFLQQSNPGLN 575

  Fly   934 -ASTRKSSDSDRNQEQPPPPLQ 954
             .|.:.||.:...|:..|..:|
Mouse   576 FGSVQLSSGNSNIQQLTPVNMQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	20/45 (44%)
		PAS	352..>405	CDD:238075	19/52 (37%)
		PAS_11	539..646	CDD:291273	28/114 (25%)
Clock	NP_001276755.1	bHLH-PAS_CLOCK	29..89	CDD:381577	24/56 (43%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:19414601	32..47		5/10 (50%)
		PAS	109..>177	CDD:366402	22/75 (29%)
		PAS_11	274..377	CDD:373151	27/109 (25%)
		Interaction with NR3C1. /evidence=ECO:0000269\|PubMed:19141540	371..854		62/360 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..411		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..497		27/130 (21%)
		Interaction with SIRT1. /evidence=ECO:0000269\|PubMed:18662547	450..570		28/157 (18%)
		Implicated in the circadian rhythmicity	514..564		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	814..855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740