DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gce and arnt

DIOPT Version :9

Sequence 1:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_012825275.1	Gene:	arnt / 100144695	XenbaseID:	XB-GENE-855450	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	780	Identity:	144/780 - (18%)
Similarity:	261/780 - (33%)	Gaps:	243/780 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKHAFGNS------- 336
            ||..:..|:.||:|:...|.|||.|||..:...|:.||..:||.|...::.....||:
Frog    84 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTPTDGTYK 148

  Fly   337 ---LMQQRPQITDTLMDMLDSFFLTLTCH-GHILLISASIEQHLGHCQSDLYGQSIMQITHPEDQ 397
               |..|  ::...:::..|.|...::|. |.|:.:|.|:...|...||:.:|.::....||:|.
Frog   149 PSFLTDQ--ELKHLILEAADGFLFVVSCETGRIVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDL 211

  Fly   398 NMLKQQLIPTELENLFDAH------GDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAGP 456
            :.|::||  :..||.....      |....||   |:|..      |.....||||..|:.....
Frog   212 DKLREQL--STAENAMTGRILDLKTGTVKKEG---QQSSM------RMCMGSRRSFICRMRCGNA 265

  Fly   457 RSEPTAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIP----------LH---- 507
            ..||:                          |.|.....|.|.|:.:.|          :|
Frog   266 VIEPS--------------------------SMNRLSFMRNRCRNGLGPSKDGEPQFVVVHCTGY 304

  Fly   508 ---------TISGND----------IILTGCARIIRPPKIASRLIDANT----LEYKTRHLIDGR 549
                     |:..:|          ::..|..::...|...    |.||    :|:.:||.:||.
Frog   305 IKAWPPAGVTLPEDDPDAGQSSKFCLVAIGRLQVTSSPTCT----DINTVCQPIEFISRHGVDGL 365

  Fly   550 IIDCDQRIGIVAGYMTDEVRNLSPFTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNII 614
            ....|.|.....||...|:.......|.|.:|.:.:..:.:|:...........:|..::....:
Frog   366 FTFVDHRCTATVGYQPQELLGKDIVEFAHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWL 430

  Fly   615 YLQSKGYLEIDKETNKVHSFVCVNTL------------------------------LGEEE--GK 647
            .:::..:...:..::::...:|.||.                              :|:.:  |:
Frog   431 LMRTSSFTFQNPYSDEIEYIICTNTNVKNSNQEPRPALASTIQRPPLGPSINHPMDMGQTQLPGR 495

  Fly   648 RRVQEMKKKFSVI---------INTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGHDD 703
            ::..:...:..|:         .:||:|...:....|:|...|||.
Frog   496 QQQPQAPPQTDVVPSREGLGSYNHTQVPVQPVSAAVSDHSKPLEKT------------------- 541

  Fly   704 GDEDDDAQDGDDDEEDD-------DDDQDDGARSMSEFGDPYG-SHHGRSHHGSSALSS------ 754
                    :|...:|.|       .:...|.::|:    :|.| |.:.:....||..:|
Frog   542 --------EGMYGQERDPRFAEIYSNINSDQSKSL----NPSGVSGNQQLFQQSSTFTSAPRPVE 594

  Fly   755 --HGHGNAKTPPLALVPPEASSVKSAITKSISVVNVTAAKHLRGIHASTAVK------------- 804
              ...|....|.:...|..|..:.:.|::..|...||......|...|...:
Frog   595 SFRSGGMVPQPSIIQQPVSAGQILAQISRHTSPTQVTGTNWSSGTRPSFTAQQVPTQTPKTQASQ 659

  Fly   805 --------SPSSLGSCTC-SDSHSPCDFCQGAPTTDLQAVGSNLKRGSTAHVETEEKLSKRRF-- 858
                    :|||....:. |.:.||.    |||...:        .|.|::..||....:.:|
Frog   660 FGMGNFQATPSSFSPLSSQSSTASPA----GAPYPSM--------TGRTSNFATEVAQPRGQFQA 712

  Fly   859 --------IPSTEIEHVLHTSLDQIGRNLTQQLN-------VARNLREQSQRYELPHANQRFDEI 908
                    .|..:.:|...::.:.   :::||.|       :...|.:|:..|    :|:.|.|:
Frog   713 RAADAVGVWPQWQSQHHGQSTAES---HVSQQSNQTEVFPDMLSMLGDQTSSY----SNEEFSEL 770

Fly 909 908
Frog 771 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gce	NP_001188593.1	HLH	279..325	CDD:238036	19/45 (42%)
		PAS	352..>405	CDD:238075	16/53 (30%)
		PAS_11	539..646	CDD:291273	19/138 (14%)
arnt	XP_012825275.1	bHLH-PAS_ARNT	79..143	CDD:381517	21/58 (36%)
		PAS	156..262	CDD:366402	30/116 (26%)
		PAS_11	355..455	CDD:373151	16/99 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910