Protein Alignment CG5877 and nrde2

DIOPT Version :9

• Sequence 1: NP_001259563.2
• Gene: CG5877 / 32455
• FlyBaseID: FBgn0030625
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: XP_005158613.1
• Gene: nrde2 / 794348
• ZFINID: ZDB-GENE-111117-3
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1253
• Identity: 234/1253 - (18%)
• Similarity: 424/1253 - (33%)
• Gaps: 373/1253 - (29%)

  Fly     1 MSLFPAYGAGRTSAAGSAKQTTKPGEEEPSTGGNWKKNESY-----IKKH------VNIATQGPE 54
            |:|||::..  .|.:.|:.::..|.:.|      |..|:|:     :|.|      ....|:.|.
Zfish     1 MALFPSFSG--LSGSNSSAESKAPADLE------WLSNQSFSTEDALKTHQRATDRARAETEEPA 57

  Fly    55 SDSSSSTEDSEDEADKRKQDDVTKTKNVHRGKTLEFDSSDGFYVDKVGNSS-YRNIKTLKKPARP 118
            ..|....::..|...|.|:....|.|...:.::.:...|.||..|.:..|. .:...|.::.|:.
Zfish    58 GTSEEKHKERGDNHGKSKKRKKEKKKKHKKKRSRDNSESSGFESDTIYPSDLLKKENTDREEAQV 122

  Fly   119 RYKTRMKRLGDGKYNPHD--------FSRAHSKF-SLKR---SRYVR------------------ 153
            |.......| |....|.|        ..||:.:: ||.|   :||.|
Zfish   123 RVSETFMWL-DDLQTPTDSPFCIDRRADRANWQYKSLYRGDIARYKRKGGSCLGLDLRTQAVTWT 186

  Fly   154 ----EKLIADAPSEDEVSRLQEQLIRTKVLV-----------------------------QQEPE 185
                ||...|..:|...|....||::|:.|:                             .|.||
Zfish   187 DGGPEKKRVDKKAERYFSSSTRQLLQTRGLLALPILSEGSATNSDPYIKLAVCAEEQGSSTQTPE 251

  Fly   186 -------VLDH----WLQ-------------------LHRLLNLNLDKANR-------------- 206
                   :.|.    ||:                   ...||:..:::.||
Zfish   252 SWVNPLGIYDPGTTLWLEGKGQPEVKGEQQSTEAQESNSTLLSARVEEFNRNLRENPTDIKLWLD 316

  Fly   207 ------------------------------LAVAEQQIHSLETAMEHHPSNQQILRLYTHVANAT 241
                                          .||.|:::..::.|:|.:||:..:......:....
Zfish   317 FVHFQDELAFGSGSFSSAGDCDAEMRKMSLRAVLEKKLSIMDRAVESNPSDVDLKLEKLRLCKEL 381

  Fly   242 YQANEVARRFEKMLKRNPFQYTLWSNLIMITQGDMACCNVSAVLRIYEYSMRRMHVGHNDEITRR 306
            ::...:.:.::|::..:|....||...::.||...:..:||.|..::...:..:....:..:...
Zfish   382 WEPAVLQKEWKKLVFIHPNSAPLWKKYLLFTQSHFSTFSVSKVNGVFGKCLSTLSAVQDGSMVSH 446

  Fly   307 FIIKETDVIMLKLFHNCLLFLRQSGHTNWMFALIRLSMELNFPYLTFECLQAHAGREKALIGFEE 371
            ..:..|...:|.:|.....||||:|||.....|.:..  |:|.:...:.::..|.|::  :.|.|
Zfish   447 PPLPGTQEDLLDIFLQQCHFLRQAGHTEKAVCLFQAL--LDFTFFKPDNVKNLATRQQ--VDFFE 507

  Fly   372 VVLRSGMPM------------------------PE-----------------------IWTRVEQ 389
            ....||.|.                        ||                       ||..||.
Zfish   508 PFWDSGEPRIGERGARGWKAWMLQQEKGGWVIPPEPDDDEEEEQEDSEIKDKTWPKWKIWLDVEA 572

  Fly   390 LRQAYCFLPLK-DKLASSTNVFKNKMNAERYFCSDKLVPYVHALKSQNNRLHLVLVVVQLMKLPL 453
            .|:|..:||.: ||....:.  ::..:.:|....|.:.|.:..:...:.:..|:|..:|.:.||
Zfish   573 SREANQWLPWRPDKTKGQSE--EDCEDPDRQVLFDDIGPSMIRVDRADLQAQLILAFLQFLGLP- 634

  Fly   454 IRSASLADKLNPCIEDFGESEAIEMLFAAIVDRHSYAVASLQYQFDAAMIDLAREMSVTPSY-MP 517
                                .|:...|.|  ...|:.:..|.:..:..  |..|.::   || :|
Zfish   635 --------------------GALTKFFTA--SSSSFLLDDLTFLEEGP--DPERPLT---SYDLP 672

  Fly   518 ----HLVGH--------------KLYADTVSNMLLKCVEVFIGEESKRRLLLILYLRFQKLLIV- 563
                ..|||              |...:.:.|:|.:.:.:...::  :..:.:.:|:::||.::
Zfish   673 VTGICAVGHMTCLSGCRRQAGLCKAGEEFLHNVLHQTLRLVPAQD--QAAITLCWLQYEKLKVLR 735

  Fly   564 --------LHKSMGKLTKKFFKDKRTRMRKLINLTENRNVISFYTEQA-----LCEIE--AKHYR 613
                    ..||.||.:|:..|       :|:...|||..::.:.|.|     |..:|  .|.:.
Zfish   736 CLRSGNKRQMKSQGKRSKRLAK-------RLLKEPENRGSLALWREYAHLEWLLGNLEEARKVFD 793

  Fly   614 LGFSI-ISRIITKKSEESSCISCVDTMHLYLVCAELHIHR-------GRISKAIGILVSLCLEKH 670
            ...|: :||.:   ::...|..|    .||   |:|.:.:       ...|||:.||..|.
Zfish   794 TALSMGVSRGL---NDHVLCKLC----FLY---AQLEVEQALSSETVSTFSKAVYILTKLA---- 844

  Fly   671 AGVKQTTVYSKEQVLKGLRNAEKMVRAELKSLDTQPAEMSLEEYFQPNKLLILLRAICLIEVLNN 735
            .|...|....:...:..|:..:...:|.|..|..|..:.:.....:.|:...|:....|.:.|..
Zfish   845 EGASYTPFSGQINPVVILKARKAYEQALLSILPEQNTDSNAGASKKHNRTSSLIGCFGLFQYLTM 909

  Fly   736 RRHKEARMWLNDLQN---NEFGPEAVKDSERKRFLREQIMEIQMLHLRLSFLVFGEVEFYTGFKK 797
            .......::...:|.   :.|..||.:.|.|:..:......:.:.|:.|
Zfish   910 GIDAAQAVYSQAIQKLIPSHFNSEAAEGSRRRSTIFADCEAVAVQHVAL---------------- 958

  Fly   798 IKLHELLENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVAIHNRFGIVDT 862
            ::.|    .....||.:.:.|.|..:|..:             ...|||.||.:...|.:.....
Zfish   959 LRHH----TNTNVFPLSRLRLALTDALSLL-------------PSSASLWHLYLQTENHYHSAGR 1006

  Fly   863 NDKFSKEATRK---------------MVCNRLVSIVETFLPTN-LDRLDVE--EEHYRILRRNS- 908
            ..:|.....:|               .:...|.|:..:.||.. |..|.|.  ....|.|..::
Zfish  1007 TRRFFHSMAKKTDSVVPYLFAITAEQRLKQLLDSVQRSRLPGEALPTLPVNGLSNRIRCLFESAT 1071

  Fly   909 ---------IYWRLYM-IALSKTNASFRRSKEVLIMAMDECPWDKSLLMEGAKVLPVKLASLQDL 963
                     :.||:|: ..:...||.  |...:...|:.|.||.|.|.|:..::.|.::....||
Zfish  1072 GTEHGAHCPLLWRMYLNFMVCDGNAD--RGSGIFYKALQEVPWVKGLYMDAVQLFPERVQEFLDL 1134

  Fly   964 MTEKEIRIFAMPEEVDVL 981
            |||||:|:....||||:|
Zfish  1135 MTEKELRLRMPMEEVDIL 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5877	NP_001259563.2	NRDE-2	180..>348	CDD:285605	38/270 (14%)
nrde2	XP_005158613.1	NRDE-2	299..632	CDD:285605	56/338 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55686
OrthoDB	1	1.010	-	-		D231700at33208
OrthoFinder	1	1.000	-	-		FOG0003950
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104167
Panther	1	1.100	-	-	LDO	PTHR13471
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1860
SonicParanoid	1	1.000	-	-		X4981
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840