Protein Alignment CG5877 and NRDE2

DIOPT Version :10

• Sequence 1: NP_573014.2
• Gene: CG5877 / 32455
• FlyBaseID: FBgn0030625
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_060440.2
• Gene: NRDE2 / 55051
• HGNCID: 20186
• Length: 1164
• Species: Homo sapiens
• Alignment Length: 1197
• Identity: 230/1197 - (19%)
• Similarity: 415/1197 - (34%)
• Gaps: 345/1197 - (28%)

  Fly    19 KQTTKPGEEEPSTGGNWKKNESYIKKHVNIATQGPESDSSSSTEDSEDEADKRKQ---DDVTKTK 80
            |||::..::|.......:.::...:||      ||.|.|.|.| |::.|.||..:   ....:::
Human    76 KQTSRKKKKEKKKKRKHQHHKKTKRKH------GPSSSSRSET-DTDSEKDKPSRGVGGSKKESE 133

  Fly    81 NVHRGKTLEFDSSDGF-YVDKVGNSSYRNIKTLKK--PARPRYKT-------RMKRLGDG--KYN 133
            ..::|.....|:...| :::.:...:....:|.||  ||...||:       |.||.||.  ..|
Human   134 EPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGIN 198

  Fly   134 PH------DFSRAHSKFSLKR-SRYVREKLI-------------ADAPSEDEVSRLQEQLIRTKV 178
            |.      :.:....|.|.|: .||..:|.:             .:.||.:.:|     .|..|.
Human   199 PKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPIS-----FIPVKD 258

  Fly   179 LVQQEP------------EVLDHWLQ------------------LHRLLNLNLDKANRLA----- 208
            |....|            :...||||                  ....|...:::.||..
Human   259 LEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPR 323

  Fly   209 --------------------------------------VAEQQIHSLETAMEHHPSNQQILRLYT 235
                                                  :.|:::..||.|:|.:.|:..:.....
Human   324 DTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKL 388

  Fly   236 HVANATYQANEVARRFEKMLKRNPFQYTLWSNLIMITQGDMACCNVSAVLRIYEYSMRRMHVGHN 300
            .:....::.:.:.:.::|::..:|....||...::..|...:..::|.:..:|...:..:....:
Human   389 KLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKD 453

  Fly   301 DEITRRFIIKETDVIMLKLFHNCLLFLRQSGHTNWMFALIRLSMELNF----------------- 348
            ..|.....:..|:..|..||.....||||:||:....:|.:..::..|
Human   454 GSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEF 518

  Fly   349 --PYLTFECLQAHAGREKALIGF---------------------------EEVVLRSGMPMPEIW 384
              |:  ::..:..|| ||...|:                           ::.:....:|..:||
Human   519 FEPF--WDSGEPRAG-EKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIW 580

  Fly   385 TRVEQLRQAYCFLPLK-DKLASSTNVFKNKMNAERYFCSDKLVPYVHALKSQNNRLHLVLVVVQL 448
            ...|:.|....:.|.: ||....|.  ::..:.||....|.:...:..|.|.:.:..||...:|.
Human   581 LAAERSRDQRHWRPWRPDKTKKQTE--EDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQF 643

  Fly   449 MKLPLIRSASLADKLNPCIEDFGESEAIEMLFAAIVDRHSYAVASLQYQFDAAMIDLAREMSVTP 513
            :.:|                 .|.:.....|:.| :|.:|.        ||..:.|........|
Human   644 LGVP-----------------SGFTPPASCLYLA-MDENSI--------FDNGLYDEKPLTFFNP 682

  Fly   514 SY--------MPHLVGHKLYA--------DTVSNMLLKCVEVFIGEESKRRLLLILYLRFQKLLI 562
            .:        |..| |:..:.        :.:.|:....:.:|.|:|..:.....|.....|::.
Human   683 LFSGASCVGRMDRL-GYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIW 746

  Fly   563 VLH-------KSMGKLTKKFFKDKRTRMRKLINLTENRNVISFYTEQALCEIEAKHYRLGFSIIS 620
            .||       ||.||..||..|:       |:...||.|....:.:.|..|     :.||.:..:
Human   747 CLHTKNKKRLKSQGKNCKKLAKN-------LLKEPENCNNFCLWKQYAHLE-----WLLGNTEDA 799

  Fly   621 RII---------TKKSEESSCISCVDTMHLYLVCAEL------HIHRGRISKAIGILVSLCLEKH 670
            |.:         :::.::|      |...|.|:.|||      .:.|...::|:.||..|.....
Human   800 RKVFDTALGMAGSRELKDS------DLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSP 858

  Fly   671 AGVKQTTVYSKEQVLKGLRNAEKMVRAELK-----SLDTQPAEMSLEEYFQPNKLLILLRAICLI 730
            .|     .|:.:.:...:..|.|.....|:     |..:.||...     ..::|:.|.:...|.
Human   859 YG-----PYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTD-----SCSRLISLAKCFMLF 913

  Fly   731 EVLNNRRHKEARMW---LNDLQNNEFGPE--AVKDSERKRFLREQIMEIQMLHLRLSFLVFGEVE 790
            :.|........:::   ...|.::.| ||  ...||...:.....:..|.::|..|       :.
Human   914 QYLTIGIDAAVQIYEQVFAKLNSSVF-PEGSGEGDSASSQSWTSVLEAITLMHTSL-------LR 970

  Fly   791 FY---TGFKKIKLHELLENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVA 852
            |:   :.:....|.|.|...|:.:|.|.|   ||                |:...|.:.:|....
Human   971 FHMKVSVYPLAPLREALSQALKLYPGNQV---LW----------------RSYVQIQNKSHSASK 1016

  Fly   853 IHNRFGIVDTNDK------FSKEATRKMVCNRLVSIVETFLPTNLDRLDVEEEH---------YR 902
            ....|..:..:.|      |:.||.:  :..|||..|:        |||..|.|         :|
Human  1017 TRRFFDTITRSAKPLEPWLFAIEAEK--LRKRLVETVQ--------RLDGREIHATIPETGLMHR 1071

  Fly   903 I-------LRRNS-----IYWRLYM-IALSKTNASFRRSKEVLIMAMDECPWDKSLLMEGAKVLP 954
            |       :|.:|     :.||:|: ..:|..|.  .|||.|...|:..|||.|.|.::..:..|
Human  1072 IQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNK--ERSKGVFYKALQNCPWAKVLYLDAVEYFP 1134

  Fly   955 VKLASLQDLMTEKEIRIFAMPEEVDVL 981
            .::..:.|||||||:|:....||:::|
Human  1135 DEMQEILDLMTEKELRVRLPLEELELL 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5877	NP_573014.2	NRDE-2	180..>348	CDD:462472	33/240 (14%)
NRDE2	NP_060440.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..149		18/79 (23%)
		NRDE2_MID	162..258	CDD:412062	24/100 (24%)
		MID/MTR4-interacting domain. /evidence=ECO:0000269|PubMed:30842217	163..266		27/107 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..305		4/25 (16%)
		HAT 1	305..337		3/31 (10%)
		NRDE-2	313..645	CDD:462472	51/336 (15%)
		HAT 2	395..427		4/31 (13%)
		HAT 3	758..792		12/45 (27%)
		HAT 4	978..1010		11/50 (22%)
		HAT 5	1067..1101		7/33 (21%)