Protein Alignment CG5877 and nrl1

DIOPT Version :9

• Sequence 1: NP_001259563.2
• Gene: CG5877 / 32455
• FlyBaseID: FBgn0030625
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_596369.1
• Gene: nrl1 / 2540691
• PomBaseID: SPBC20F10.05
• Length: 972
• Species: Schizosaccharomyces pombe
• Alignment Length: 1081
• Identity: 188/1081 - (17%)
• Similarity: 374/1081 - (34%)
• Gaps: 343/1081 - (31%)

  Fly     5 PAYGAGRTSAAGSAK--QTTKPGEEEPSTGGNWKKNESYIKKHVNIATQGPESDSSSSTEDSEDE 67
            |.|....:|..|||.  :..|..:|    |....|.:|...|:                 |.|..
pombe    79 PKYHRSSSSVYGSAPLLRIVKESKE----GITLNKKKSLEIKY-----------------DEERS 122

  Fly    68 ADKRKQDDVTKTKNVHRGKTLEF-DSSDGF---YVDKVGNSSYRN------IKTLKKPARPRYKT 122
            .|:::.|:            .|| |...||   .|::..:.|.::      :|.:|:...
pombe   123 FDEKENDE------------SEFEDGQQGFIPLLVNRNSDPSEKSTFSLNILKAIKETDE----- 170

  Fly   123 RMKRLGDGKYNPHDFSRAHSKFSLKRSRYVREKLIADAPSEDEVSRLQEQLIRTKVLVQQEPEVL 187
                  :.|.||     ..::..:|...| :|:|:.     ||..|.....|:.|:.::
pombe   171 ------EIKKNP-----GKARLWIKMCEY-QERLLF-----DEFRRSNSDDIKGKLKIE------ 212

  Fly   188 DHWLQLHRLLNLNLDKANRLAVAEQQIHSLETAMEHHPSNQQILRLYTHVANATYQANEVARRFE 252
                        |..::.:|::.|:.:..:: ..:|    :.::..|..:.:..:...|..::||
pombe   213 ------------NNSRSVKLSILEKALKEVK-GCDH----EILVSYYLQLGSEEWSKEETNQKFE 260

  Fly   253 KMLKRNPFQYTLW-------SNLIMITQGDMACCNVSAVLRIYEYSMRRM------HVGHNDEIT 304
            ::|..:|....||       :.:...|..|  |.|:.:  :.:::..:::      ....:.::|
pombe   261 EVLIEHPGYLNLWMKYAEYFTGISEFTFND--CLNMFS--KCFKFLKQKLSDRKSCKERESTDVT 321

  Fly   305 RRFIIKETDVIMLKLFHNCLLFLRQSGHTNWMFALIRLSMELNFPYLTFECLQAHAGREKALIG- 368
            ..|.::|.   :|.|......||:..|:....:::.:.:|||.:.|..:        .||.|..
pombe   322 SNFEVEEA---ILHLLIRLCDFLKNCGYYELAWSIFQANMELCYFYPRY--------LEKKLDST 375

  Fly   369 -FEEVVLRSGMPMPEIWTR-----VEQLRQAYCFLPLKDKLASSTNVFKNKMNAERYFCSDKLVP 427
             ||.        ..:.|..     .|:..:.:|.: |.|:.:.....|.:::.   .|.:.||.
pombe   376 FFES--------FSKFWNSDTPKFSEENARGWCNV-LDDESSQQNQNFSSEIG---IFQTVKLW- 427

  Fly   428 YVHALKSQNNRLHLVLVVVQLMKLPLIRSASLADKLNPC-----------IEDF---GESEAIEM 478
            |::..|...|              |..||.....||:..           |:||   .|||.|..
pombe   428 YLNESKFDTN--------------PPPRSTMSCRKLSGIDDPFRYIVFNDIQDFIVCFESETIAF 478

  Fly   479 LFA----------------------AIVDRHSY----AVASLQ------------YQFDAAMIDL 505
            .|.                      |..|:..|    .:||.:            :||..
pombe   479 AFKYKFFAFCGVPLFPPGISTNSWFASYDKGIYNLLFGMASSESFINGQIAEKNSFQFPC----- 538

  Fly   506 AREMSVTPSYMPHLV--------GHKLYADTVSNMLLKCVE------VFIGEESKRRLLLILYLR 556
                |:.|||:...:        ..||:...:::.:.:.:|      ||..::.....:.::||:
pombe   539 ----SILPSYIDLFISLMSFKNLNFKLFDYNLAHHVKESMERAFHQLVFSADDEYLASVYLIYLK 599

  Fly   557 FQKLLIVLHKSMGKLTKKFFKDKRTRMRKLIN--LTENRNVISFYTEQALCEIEAKHYRLGFSII 619
                         ::..|...:::.::.|::.  |.:..:.:|.:...|    :.:|....|::.
pombe   600 -------------QMETKNLSEEKPQVNKIVKKILKKYDSSVSVWNTYA----QLEHLSGAFTMA 647

  Fly   620 SRII-TKKSEESSCISCVDTMHLYLVCAELHIHRGRISKAIGILVSL-CLEKHAGVKQTTVYSKE 682
            ..|. |.....:|.:..:|.:::|...|   ..:..|:...|.||.: ||
pombe   648 ETIFKTIFQIHASQLRYIDNLNVYKNWA---FRKLLINDTEGCLVIIKCL--------------- 694

  Fly   683 QVLKGLRNAEKMVRAELKSLDTQPAEM---SLEEYFQPNKLLILLRAICLIEVLNNRRHKEARMW 744
                 |...:|    .|.|.:.:.:||   .||......:||.    :|||..:          |
pombe   695 -----LFPGDK----SLTSDNNRASEMLFGMLENCASKEELLY----VCLIYTI----------W 736

  Fly   745 -----LNDLQNNEFGPEAVKDSERKRFLREQIMEIQMLHLRLSFLVFG-EVEFYTGFKKIKLHEL 803
                 ::.:.|..:  ..::..|...:.....||....:..|.|.... .::||   ...|:...
pombe   737 THCTDMDSMDNCVY--LCIQKFESYGWGASSEMECYFSYCSLIFYYQATTLQFY---NLPKVRPF 796

  Fly   804 LENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVAIHNRFGIVDTNDKFSK 868
            .|.|:..|..|....:::...:|.:..:.:.: ||....:.|.::.||.
pombe   797 FEKGVTLFSANTAIWEVYIFFESKLRQENKPK-IRAMKILKSASNAVVT---------------- 844

  Fly   869 EATRKMVCNRLVSI-VETFLPTN----LDRLDVEEEHYRILRRNSIYWRLYMIALSKTNASFRRS 928
                  .|..|..: |:...|||    |..||:...:.: |:..:.:||:|:..|:.........
pombe   845 ------ACWYLFYVAVQQIEPTNSQYFLRTLDITLNNEK-LKSVAKFWRIYLKILNLRLNGTEWV 902

  Fly   929 KEVLIMAMDECPWDKSLLMEGAKVLPVKLASLQDLMTEKEI 969
            ..:...|:..||.:|.:.|:           :.||:.:||:
pombe   903 SAITTKALASCPCNKGVCMD-----------VIDLLLKKEM 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5877	NP_001259563.2	NRDE-2	180..>348	CDD:285605	27/180 (15%)
nrl1	NP_596369.1	NRDE-2	167..476	CDD:285605	68/395 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003950
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104167
Panther	1	1.100	-	-	LDO	PTHR13471
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1860
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930