Protein Alignment CG5877 and nrde-2

DIOPT Version :9

• Sequence 1: NP_001259563.2
• Gene: CG5877 / 32455
• FlyBaseID: FBgn0030625
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_496209.1
• Gene: nrde-2 / 174589
• WormBaseID: WBGene00011333
• Length: 1270
• Species: Caenorhabditis elegans
• Alignment Length: 1237
• Identity: 208/1237 - (16%)
• Similarity: 403/1237 - (32%)
• Gaps: 386/1237 - (31%)

  Fly    12 TSAAGSAKQTTKPGEEEPSTGGNWKKNESYIKKHVNIATQGPESDSSSSTEDSEDEADKRKQDDV 76
            ||...::::.:......||            :.|.....:......|.|.|....:.::|::...
 Worm   132 TSQQSTSRKRSASNSRSPS------------RSHSRRYDRDNGRQRSRSREKKRRKKERRRKRSS 184

  Fly    77 TKTKNVHRGKTLEFDSSDGFYVDKVGNSSYRNIKTLKKPARPRYKTRMKRLGDGKYNPHD----- 136
            :::.:..|.:    |.|     .:..::|...:..:.|||:..:.|      |.:|...|
 Worm   185 SRSSSSSRSR----DRS-----SRARDTSSHTLMKMNKPAKYAFLT------DEEYRTCDAYISS 234

  Fly   137 ------------FSRAHSKFSLKRSR-----------------------YVREKLIADAPSEDEV 166
                        :::...|..:.:.|                       |.|:|  .:.|..:::
 Worm   235 AFITQTKSDCENYTQGVPKKEIAKCRLSVKFIVGLEHNNILFNNIYGAEYARDK--ENRPFWEQL 297

  Fly   167 SRLQEQLIRTKVLVQQEPEVLDHWLQLHRLLNLNLDKANRLAVA--------------------- 210
            .|..:. :..:...:..|.|..:|....|:..||||..:...:|
 Worm   298 DRYLKD-VPKETFFRYVPPVGGYWKIRDRVDLLNLDHIDDDVLANDSDNRKDAFTFELEQAKKTF 361

  Fly   211 EQQIHSLETAMEHHPSNQQILRLYTHVANATYQANEVARRFEKMLK-------RN---------- 258
            .:.:|:::..::.....:::.|......:::..| .:|.|.::|:|       ||
 Worm   362 SENVHNIDALIKVISMEEEMCRRNVGSFSSSNPA-ALAERHQEMVKKAIKADGRNAKLRLMKIEL 425

  Fly   259 ----------------------PFQYTLWSNLIMITQGDMACCNVSAVLRIYEYSMRRMHVGHND 301
                                  |.:..:|...:...|.|....|...:...:|..:|::     .
 Worm   426 LIKMDPNSPTIIDDFKNLTITFPHEPMVWIKYLDYIQYDSNVYNYKKLKNAFEDCIRQV-----T 485

  Fly   302 EITRRFIIKETDVI----MLKLFH-----NCLLFLRQSGHTNWMFALIRLSMELNFPYLTFECLQ 357
            .:|...::...:.:    :|::||     ..|.::....||..:.|.|:.:.|.||
 Worm   486 GLTNGTLLSHLNAVNDRPLLRMFHLWIYIRYLKWMISCAHTPVVLANIQATFEYNF--------- 541

  Fly   358 AHAGREKALIGFEEVVLRSGMPMPEIWTRVEQLRQAYCFLPLKDKLASSTNVFKNKMNAERYFCS 422
                      |..:|..|:.....|...|:|:..::  .||   ::.....|...||..:....|
 Worm   542 ----------GLADVEKRTSTNSKEREVRLEEFWES--GLP---RIGDEGAVGAEKMLKQSEELS 591

  Fly   423 DKLVPYVHALKSQNNRLHLVLV--------------VVQLMKLPLIRSASLAD------KLNPC- 466
            |:.:.     |.:|:...:::.              .||:..:.:.|.....|      ||..|
 Worm   592 DEDIQ-----KLENDDFDILISRTEETIATCLQAQRDVQISWIEVEREMMNIDARVKRTKLKDCE 651

  Fly   467 -IED-FGESEAIEMLFAAIVDRHSYAVA---SLQYQFDAAMIDL--------------------- 505
             .|| ..:.|..|:......||..|..|   ...:.|....::|
 Worm   652 LYEDHVDDLETCELWDIIPFDRIRYYEAPGDCANFDFVQPFLELLGVKFLNSTNCFTTTEQIISD 716

  Fly   506 --AREMSV----TPSYMPHL---VGHKL-----------------YAD-TVSNMLLKCVEVFIGE 543
              :.:.:|    ||:|....   ||:.:                 |.| |:...||..:.....|
 Worm   717 WISNDSTVNFYKTPTYTEKKCFEVGNNILKFMLYNRLKLTENNPEYLDKTMVKYLLAMLVTEASE 781

  Fly   544 ESKRRLLLILYLRFQKLLIVLHKSMGK-LTKKFFKDKRTRMRKLINLTENRNVISFYTEQALCE- 606
            :.|:       |.|....:.|...:|. :||.....||..:.|:..:......:|:: |:||.|
 Worm   782 QEKK-------LNFHSFKLNLKNLVGTFITKHPDIFKRAMLSKITGIVYMEKFVSWW-ERALKEQ 838

  Fly   607 ---IEAKHYRLGFSIISR------------IITKKSEE-------------------------SS 631
               :||...|..:..|..            |:.||.:|                         .|
 Worm   839 EKVVEADERRKNYKEIKMEEGVVDDVKFDVILLKKDKERVQTIRDKIRDMIDIAIPKSTEKLIQS 903

  Fly   632 CISCVDTMHLYLVCAELHIHRGRISKAIGILVSLCLEKH--------AGVKQTTVYSKEQVL--- 685
            ..|.:.|:.|:|..   ::.|||:|    ||....||:.        .|:..:...|.|.:|
 Worm   904 ADSSLPTLQLHLYA---NVLRGRLS----ILNQNALEETRDVFCKEILGIHTSEFESDEALLLAL 961

  Fly   686 -KGLRNAEKMVRAE--LKSLDTQP----AEMSLEE------YFQPNKLLILLRAI-CLI-EVLNN 735
             :||....:..:.:  |:|:|:.|    ||...|.      :...:|:....||: ||| ..:..
 Worm   962 DQGLNELLEHCKEKDNLESVDSIPELPRAEALCEALKVVAVFVFLDKMAFSRRAVDCLIANAITK 1026

  Fly   736 RRHKEARMWLNDLQNNEFGPEAVKDSERKRFLREQIMEIQMLHLRLSFLVFGEVEFYTGFKKIKL 800
            ....||:.  ||.....:  |...|....:|:.:.::.. ..|.:..|:      :...|||
 Worm  1027 FEQFEAKK--NDFNRGTY--EKYCDQIDLKFITDTLITF-FSHKKHRFI------YNENFKK--- 1077

  Fly   801 HELLENGLEEFPRNMVFLQLWASLKSIMWHKQRSRLIRTKAGIASLAHLVVAIHNRFGIVDT--N 863
              |:....:.||.:..:.::...|.|              :|...:..|.....:|..|::.  :
 Worm  1078 --LIFQASQAFPCDSKYAKMLGELHS--------------SGRLQVMKLQGFTDSRNSILNAKRD 1126

  Fly   864 DKFSKEATRKMVCNRLVSIVETFLPTNLDRLDVEEEHYRILRRN----------SIYWRLYMIAL 918
            .:|..|...:::.|.|..:.......|    .:.:...:||.:|          ...||..:...
 Worm  1127 QQFDPELETRLLMNSLTIMFSWMNAAN----RIGDAGNQILYKNWKREAANTRDPAIWRQVIRVA 1187

  Fly   919 SKTNASFRRSKEVLIMAMDECPWDKSLLMEGAKVLPVK----LASLQDLMTE----KEIRIFAMP 975
            ||.:....:. :....|..:|.|..:|..:..:...|:    |..:..|:.|    :|..:|...
 Worm  1188 SKLSQKILKD-DAYTRARGQCTWALNLHFDYIEAKTVRKNGDLMEMIYLILEQSMGQEHSLFVTD 1251

  Fly   976 EE 977
            ||
 Worm  1252 EE 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5877	NP_001259563.2	NRDE-2	180..>348	CDD:285605	35/236 (15%)
nrde-2	NP_496209.1	NRDE-2	353..671	CDD:369867	54/352 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1972
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003950
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13471
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1860
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960