DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9095 and SELP

DIOPT Version :9

Sequence 1:	NP_001096984.1	Gene:	CG9095 / 32447	FlyBaseID:	FBgn0030617	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_002996.2	Gene:	SELP / 6403	HGNCID:	10721	Length:	830	Species:	Homo sapiens

Alignment Length:	366	Identity:	92/366 - (25%)
Similarity:	146/366 - (39%)	Gaps:	65/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 YNRQPLNFLDALSFCRSRGGTLISESNPALQGFISWELWRRHRSDVSSQYWMGAVRDGSDRSSWK 329
            |:.:..::..:..:|::|...|::..|.....:::..|     ...||.||:| :|  .:..:|.
Human    46 YSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVL-----PYYSSYYWIG-IR--KNNKTWT 102

  Fly   330 WVNGDE-LT--VSFW-----SHPGGDEDCARF---DGSKGWLWSDTNC----------------- 366
            ||...: ||  ...|     ::...:|||...   ..|....|:|.:|
Human   103 WVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMS 167

  Fly   367 --------NTLLNFICQHQP----------KTCGRPEQPPNSTMVA---LNGFEVGAQIKYSCDA 410
                    .|:.|:.|...|          :.||..|.|.:..|..   |..|...:|..:.|..
Human   168 CSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTD 232

  Fly   411 NHLLVGPATRTCLETGFYNEFPPVCKYIECGLPASI-AHGSYALLNNTVGY--LSLVKYSCEEGY 472
            .:.:.||:...||.:|.:...||.|...:|. |..| ..|:...|::...:  .|...:|||||:
Human   233 GYQVNGPSKLECLASGIWTNKPPQCLAAQCP-PLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGF 296

  Fly   473 EMIGRALLTCDFDERWNGPPPRCEIVECDTL--PGNYYSTIINAPNGTYYGSKAEISCPPGYRME 535
            .::|..::.|.....|..|.|.|:.|:|..|  |.......::......|||..:..|.||||:.
Human   297 ALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVR 361

  Fly   536 GPRVLTCLASGQWSSALPRC--IKLEPSTQPTAASTIPVPS 574
            |..:|.|:.||.||:.||.|  |..||...|...|....||
Human   362 GLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPS 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9095	NP_001096984.1	CCP	37..93	CDD:153056
		FTP	94..242	CDD:128870
		CLECT	256..375	CDD:214480	27/145 (19%)
		Sushi	381..435	CDD:278512	16/56 (29%)
		CCP	440..496	CDD:153056	16/58 (28%)
		CCP	500..556	CDD:153056	21/59 (36%)
SELP	NP_002996.2	CLECT_selectins_like	42..160	CDD:153062	25/121 (21%)
		EGF_CA	<168..195	CDD:238011	4/26 (15%)
		CCP	200..257	CDD:153056	16/56 (29%)
		CCP	262..320	CDD:153056	16/58 (28%)
		CCP	324..382	CDD:153056	20/57 (35%)
		CCP	386..444	CDD:153056	6/17 (35%)
		CCP	448..506	CDD:153056
		PHA02927	505..761	CDD:222943
		CCP	510..568	CDD:153056
		CCP	572..630	CDD:153056
		CCP	642..700	CDD:153056
		CCP	704..762	CDD:153056
		Endocytosis signal. /evidence=ECO:0000305	818..821
		Interaction with SNX17	821..830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11997
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19325
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100