DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9095 and Selp

DIOPT Version :9

Sequence 1:	NP_001096984.1	Gene:	CG9095 / 32447	FlyBaseID:	FBgn0030617	Length:	1141	Species:	Drosophila melanogaster
Sequence 2:	NP_037246.2	Gene:	Selp / 25651	RGDID:	3656	Length:	768	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	119/502 - (23%)
Similarity:	187/502 - (37%)	Gaps:	139/502 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 SYNGKCYIFYNRQPLNFLDALSFCRSRGGTLISESNPALQGFISWELWRRHRSD----VSSQYWM 316
            :|:.|.|.:.|.:        :||:.....|::..|..       |:  .|.:|    |:|.||:
  Rat    45 NYSTKAYSWNNSR--------AFCKRHFTDLVAIQNKN-------EI--AHLNDVIPYVNSYYWI 92

  Fly   317 GAVRDGSDRSSWKWV-----------------------NGD--ELTVSFWSHPG--GDEDCARFD 354
            | :|..:::  |.||                       |.|  |:.:...|.||  .||.|  |.
  Rat    93 G-IRKINNK--WTWVGTNKTLTAEAENWADNEPNNKRNNQDCVEIYIKSNSAPGKWNDEPC--FK 152

  Fly   355 GSKGWLWS----DTNCN-------TLLNFICQHQP----------KTCGRPEQPPNSTMVA---L 395
            ..:...::    |.:||       |:.::.|...|          :.||:.:.|.:..|..   |
  Rat   153 RKRALCYTASCQDMSCNSQGECIETIGSYTCSCYPGFYGPECEYVQECGKFDIPQHVLMNCSHPL 217

  Fly   396 NGFEVGAQIKYSCDANHLLVGPATRTCLETGFYNEFPPVCKYIECGLPASIAHGSYALLN--NTV 458
            ..|...:|..:||...:.|.||:...||.:|.:...||.||.::|....:..||:....:  ...
  Rat   218 GDFSFSSQCTFSCPEGYDLNGPSEMQCLASGIWTNNPPQCKAVQCQSLEAPLHGTMDCTHPLAAF 282

  Fly   459 GYLSLVKYSCEEGYEMIGRALLTCDFDERWNGPPPRCEIVECDTLPGNYYSTIINAPN-GTY-YG 521
            .|.|..|:.|:.||.|.|..:|.|....:|:.|.|.||.:.|:.|....:.::...|: |.: |.
  Rat   283 AYDSSCKFECQPGYRMRGSDILHCTDSGQWSEPLPTCEAIACEPLESPLHGSMDCFPSTGAFGYN 347

  Fly   522 SKAEISCPPGYRMEGPRVLTCLASGQWSSALPRCIKLEPSTQPTAASTIPVPS--SVATPPPFRP 584
            |.....|..|:.:.|...:.|...|||::..|.|..|:       ....||||  .|:...||
  Rat   348 SSCTFRCTEGFVLMGNDAIHCADLGQWTAPAPVCEALQ-------CQEFPVPSKAQVSCSDPF-- 403

  Fly   585 KVVSSTTSRTPYRPAVS-TASSG---IGGSSTSTVGTYPSLSPTQVEINGE-SESEEEINVPPVP 644
                   ....|:.|.| :...|   :|.|....:.|            |. ||:      ||..
  Rat   404 -------GTLKYQSACSFSCDEGSLLVGASVIRCLAT------------GHWSEA------PPEC 443

  Fly   645 GTVREEFPPRRTVRPVLIPKKPNSTPAALPPTTHQVPPQPPSTYAPT 691
            ..|        :..|:|.|:  |.|...:.|..|       |.|..|
  Rat   444 QAV--------SCTPLLSPE--NGTMTCIQPLGH-------SNYKST 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9095	NP_001096984.1	CCP	37..93	CDD:153056
		FTP	94..242	CDD:128870
		CLECT	256..375	CDD:214480	34/160 (21%)
		Sushi	381..435	CDD:278512	17/56 (30%)
		CCP	440..496	CDD:153056	16/57 (28%)
		CCP	500..556	CDD:153056	14/57 (25%)
Selp	NP_037246.2	CLECT_selectins_like	42..160	CDD:153062	30/136 (22%)
		EGF_CA	<168..195	CDD:238011	5/26 (19%)
		CCP	200..258	CDD:153056	17/57 (30%)
		PHA02927	276..505	CDD:222943	61/249 (24%)
		PHA02927	443..699	CDD:222943	11/48 (23%)
		Endocytosis signal. /evidence=ECO:0000305	756..759
		Interaction with SNX17. /evidence=ECO:0000250	759..768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19325
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	4.060