DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9095 and CR2

DIOPT Version :9

Sequence 1:NP_001096984.1 Gene:CG9095 / 32447 FlyBaseID:FBgn0030617 Length:1141 Species:Drosophila melanogaster
Sequence 2:NP_001006659.1 Gene:CR2 / 1380 HGNCID:2336 Length:1092 Species:Homo sapiens


Alignment Length:685 Identity:146/685 - (21%)
Similarity:224/685 - (32%) Gaps:215/685 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 GTVASYSCERGFELLGPARRVC-DKGQWVPEGIPFCVLNVAAGKAPMQISTDGAGAPQKAIDGST 121
            ||...|||..|:.|:|.....| .:|.|.|. :|.|  .|||                       
Human   432 GTSIKYSCNPGYVLVGEESIQCTSEGVWTPP-VPQC--K
VAA----------------------- 470

  Fly   122 SAFFTPETCSLTKAERSPWWYVNLLEPYMVQLVRLDFGKSCC-GNKPATIVVRVGNNRPDLGTNP 185
                    |..|..:        ||.....|.||.|...||. |.|.:..|.:...     ||.|
Human   471 --------CEATGRQ--------LLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ-----GTIP 514

  Fly   186 ------ICNRFTGLLEAGQPLFLPCNPP---MPGAFVSVHLEN----------STPNPLSICEAF 231
                  :|...|            |.||   ..||.....||:          ..|.|....|..
Human   515 WFMEIRLCKEIT------------CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFS 567

  Fly   232 VYTDQALPIERCPTFRDQPPGALASYNGKCYI-------------------------FYNRQPLN 271
            :..:..:   || |..||..|..:.....|.:                         |||     
Human   568 LIGESTI---RC-TSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYN----- 623

  Fly   272 FLDALSFCRSRGGTLISESNPALQGFISWE---------------LWRRHRSDVSSQYWMGAVRD 321
              |.::|....|.||...|....:...:|:               |.....:..::.:       
Human   624 --DTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVF------- 679

  Fly   322 GSDRSSWKWVNGDELTVSFWSHPG----GDED--CARFDGSKGWLWSDTNCNTLLNFICQHQPKT 380
                    :|:|  :||.:...||    |::.  |.   .|..|..|...|..    .|||..::
Human   680 --------FVSG--MTVDYTCDPGYLLVGNKSIHCM---PSGNWSPSAPRCEE----TCQHVRQS 727

  Fly   381 CGRPEQPPNSTMVALNGFEVGAQIKYSCDANHLLVGPATRTC--LETGFYNEFPPVCKYIECGLP 443
            .   ::.|..:.|.|        :..||...:.|.|.|.:.|  .|.|.:.:..|:||.|.|..|
Human   728 L---QELPAGSRVEL--------VNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPP 781

  Fly   444 ASIAHGSY-ALLNNTVGYLSLVKYSCEEGYEMIGRALLTCDFDER----WNGPPPRC----EIVE 499
            ..|.:|.: .::.....|.:.|.|.|::|:.::|...|.|..|.:    |:||.|:|    .:..
Human   782 PVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTR 846

  Fly   500 CDTLPGNYYSTIINAPNGTY-YGSKAEISCPPGYRMEGPRVLTCLASGQWSSALPRCIKLEPSTQ 563
            |.. |...:...:|..:..| :.....:.|.||:.|.|.||:.|.....|...:|.|||      
Human   847 CPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIK------ 904

  Fly   564 PTAASTIPVPSSVATPPPFRPKVVSSTTSRTPYRPAVSTASS--------GIGGSSTSTVGTYPS 620
               .:.|..|     |||..|....:..:...:.|.:|...|        |......:..||:..
Human   905 ---KAFIGCP-----PPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQ 961

  Fly   621 LSPTQVEINGESESEEEINVPPVPGTVREEFPPRR 655
            .:|...|:|..|.::.:        .:::...||:
Human   962 PAPHCKEVNCSSPADMD--------GIQKGLEPRK 988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9095NP_001096984.1 CCP 37..93 CDD:153056 13/35 (37%)
FTP 94..242 CDD:128870 31/167 (19%)
CLECT 256..375 CDD:214480 24/164 (15%)
Sushi 381..435 CDD:278512 12/55 (22%)
CCP 440..496 CDD:153056 18/64 (28%)
CCP 500..556 CDD:153056 14/56 (25%)
CR2NP_001006659.1 CCP 23..83 CDD:153056
CCP 91..147 CDD:153056
CCP 154..211 CDD:153056
CCP 215..272 CDD:153056
CCP 276..343 CDD:153056
CCP 351..407 CDD:153056
CCP 410..467 CDD:153056 14/37 (38%)
CCP 527..594 CDD:153056 16/70 (23%)
CCP 602..658 CDD:153056 10/62 (16%)
CCP 661..718 CDD:153056 12/76 (16%)
CCP 778..838 CDD:153056 17/59 (29%)
CCP 847..903 CDD:153056 14/56 (25%)
CCP 910..967 CDD:153056 12/61 (20%)
CCP <990..1028 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19325
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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