DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ap1g1 and AP-2alpha

DIOPT Version :9

Sequence 1:	XP_017212304.1	Gene:	ap1g1 / 324466	ZFINID:	ZDB-GENE-030131-3187	Length:	822	Species:	Danio rerio
Sequence 2:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	222/877 - (25%)
Similarity:	410/877 - (46%)	Gaps:	145/877 - (16%)

- Green bases have known domain annotations that are detailed below.

Zfish    18 RTQAEEREMIQKECAAIRSSFREE---DNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKF 79
            :::..|.:.|.||.|.|||.|:.:   |...:.:.|.|||::.:||:...||.:|.:.|::|.|:
  Fly    35 KSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKY 99

Zfish    80 TDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQYVQGLALCTLGCMGSSEMCRDLAGEVEK 144
            ::|:||||...:|::...|:..|:...|||||.........|||..:..:||.:|....:.|:.|
  Fly   100 SEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPK 164

Zfish   145 LLKTSNS--YLRKKAALCAVHVIRKVPELMEMFLPATK------NLLSEKNHGVLHTSVVLLTEM 201
            ||.:.::  .:::.||||.:.:.|..|::    :|..:      :||::::.||:..:..|:..:
  Fly   165 LLVSGDTMDVVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDAL 225

Zfish   202 CERSPDMLSHFRKNEKLVPQLVRILKNLIMSGYSPEHDVS--GISDPFLQVRILRLLRILGKGDD 264
            .:|:||      :.:..|...|..|..::.:.|:...|.:  .:..|:|.|::||||:......:
  Fly   226 VKRNPD------EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTE 284

Zfish   265 DS------SEAMNDILAQVATNTETSK----NVGNAILYETVLTIMDIKSESGLRVLAINILGRF 319
            ::      :|.:..||.:.....::.|    |..||:|:|.:..|:...||..|.|.|.|.||:|
  Fly   285 EAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQF 349

Zfish   320 LLNNDKNIRYVALTSL--LKTVQTDHNAVQRHRSTIVDCLK-DLDVSIKRRAMELSFALVNGNNI 381
            |.|.:.|:||:||.|:  |.|.:..|..|::|:..::..:| :.|||:::.|::|.:|:.:..|.
  Fly   350 LSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNA 414

Zfish   382 RGMMKELLYFLDSCDPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDSVPNLIQ 446
            ..:::|:|.:|::.|...:.:....:.:.|||||....|::|.|:.::..||.||.::....:||
  Fly   415 EEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQ 479

Zfish   447 LITNSVEMHAYTVQRLYKALLDDISQQPLVQVASWCIGEYGDLLVSGQCEEEEPIQVSEDEVLDV 511
            ::.|..|:..|..:.:::||......:.:|:|..:.:||:|: |::|.......:|..
  Fly   480 IVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-LIAGDSRSAPLVQFK------- 536

Zfish   512 LEGLLVS--NLSAPVTRGYSLTAIMKLSTRFSSV-NRIKKVVSIYGS--SIDVELQQRAVEYNAL 571
               ||.|  :|.:|:||...|:..:|....|..: ..|:.|...:.:  |.|.||||||.||..|
  Fly   537 ---LLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQL 598

Zfish   572 ------------------FKKYDHMRPALLE-----RMPIMEKSATNGPAEIVQTNGETDAPILD 613
                              |.:.:....|:|:     |:|..|...:..||.:  |:...:..:::
  Fly   599 SIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPL--TSAAQNNALVN 661

Zfish   614 TKHPPNIPQPISQANDLLDLLGGNDVVPVIQTTAPTKPASAGGE----LLDLLGDLSLTGGPAPT 674
            ..|     ..::.:|...||||        .:|.|:....:|..    |:|:|||:.   |....
  Fly   662 NSH-----SKLNNSNANTDLLG--------LSTPPSNNIGSGSNSNSTLIDVLGDMY---GSNSN 710

Zfish   675 PAPSVPMSQPPFLL--DGLTSQPLFNDIGAGIPPMTAYNKNGLKIEFTFERSNPNPNIAVITIHA 737
            ...|...:...||.  :|:    ||.:....|         |:|.||       ..|:..:.:..
  Fly   711 NNSSAVYNTKKFLFKNNGV----LFENEMLQI---------GVKSEF-------RQNLGRLGLFY 755

Zfish   738 TNTTEVDMTEF--VFQAAVPKTFQLQLLSPSSNVVPALNQGSVTQVIRVL--------------- 785
            .|.|:|.:|.|  |.|.:.....:|.:  ....|.|.|..|:  |:.::|
  Fly   756 GNKTQVPLTNFNPVLQWSAEDALKLNV--QMKVVEPTLEAGA--QIQQLLTAECIEDYADAPTIE 816

Zfish   786 -----NPQKQQLRMRIKLTYTHKGSPVQDLAE 812
                 |..:|:..:::.|:......|.:..||
  Fly   817 ISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAE 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap1g1	XP_017212304.1	None
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	165/578 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	25/128 (20%)
		Alpha_adaptin_C	839..947	CDD:280460	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920