DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpL37a and KCNB2

DIOPT Version :9

Sequence 1:	NP_001259561.1	Gene:	RpL37a / 32446	FlyBaseID:	FBgn0030616	Length:	93	Species:	Drosophila melanogaster
Sequence 2:	NP_004761.2	Gene:	KCNB2 / 9312	HGNCID:	6232	Length:	911	Species:	Homo sapiens

Alignment Length:	109	Identity:	22/109 - (20%)
Similarity:	31/109 - (28%)	Gaps:	45/109 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RHNKTHTLCRRCGRS-----SY----HIQKSTCAQCGYPAAKLRSYNWSVKAKRRKTTGTGRMQH 66
            |..|.|.:...|..|     .|    .|...:|.|..|...|.:     :..:.|:...|.|.
Human   104 RTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQ-----MNEELRREAETMRE-- 161

  Fly    67 LKVVRRRFRNGFREGTQ-----------------AKPKKAVASK 93
                        |||.:                 .||..:||:|
Human   162 ------------REGEEFDNTCCPDKRKKLWDLLEKPNSSVAAK 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpL37a	NP_001259561.1	PTZ00073	1..91	CDD:240257	19/105 (18%)
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		BTB	37..143	CDD:197585	10/38 (26%)
		BTB_2	37..136	CDD:280393	7/31 (23%)
		Ion_trans	230..428	CDD:278921
		Ion_trans_2	341..422	CDD:285168
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386
		Kv2channel	471..759	CDD:281514
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..571
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..665
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..739
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	760..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900